Adam Gracz
@graczlab.bsky.social
Genetic regulation of cell identity and regeneration | All things gut & liver | 🏳️🌈 | Opinions are my own | he/him/his www.graczlab.org
Reposted by Adam Gracz
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
Wait this is kind of wild…so there’s a chance that some applications will be funded but ND?
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:03 PM
Wait this is kind of wild…so there’s a chance that some applications will be funded but ND?
Reposted by Adam Gracz
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
November 24, 2025 at 12:59 AM
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Open-Rank, Tenure-Track Faculty Positions, Center for Molecular Medicine
The Center for Molecular Medicine in partnership with Departments of Biochemistry and Biophysics, Cell Biology and Physiology, Genetics, Microbiology and Immunology and Pediatrics at the University of...
unc.peopleadmin.com
November 19, 2025 at 1:45 PM
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Congratulations to Dr. Nic Janto, who defended his PhD in the GMB Program at Emory earlier this week! Nic is headed off to postdoc with Edan Foley at The University of Bath. It’s the end of an era for the lab, but very excited to follow Nic’s journey into zebrafish models of intestinal biology! 🐟
November 19, 2025 at 11:51 AM
Congratulations to Dr. Nic Janto, who defended his PhD in the GMB Program at Emory earlier this week! Nic is headed off to postdoc with Edan Foley at The University of Bath. It’s the end of an era for the lab, but very excited to follow Nic’s journey into zebrafish models of intestinal biology! 🐟
Reposted by Adam Gracz
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Amen to this! I just reviewed a revised manuscript where the rebuttal was 40-50 pages long.
We’ve got to let go of this collective delusion that any individual paper must be and is “the complete story”.
We’ve got to let go of this collective delusion that any individual paper must be and is “the complete story”.
My reviewing style has changed over time. Rather than litigate every little thing, and pushing my own ideas, I focus only on 2 things:
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
November 9, 2025 at 4:56 PM
Amen to this! I just reviewed a revised manuscript where the rebuttal was 40-50 pages long.
We’ve got to let go of this collective delusion that any individual paper must be and is “the complete story”.
We’ve got to let go of this collective delusion that any individual paper must be and is “the complete story”.
Reposted by Adam Gracz
wait, wait, what 😱
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
November 7, 2025 at 8:32 AM
wait, wait, what 😱
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Reposted by Adam Gracz
In @elife.bsky.social: Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye doi.org/10.7554/eLif...
Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye
The Sox9 gene is necessary for maintaining vision in the mouse adult eye, acting as an essential factor for retinal and corneal function.
doi.org
November 6, 2025 at 9:53 AM
In @elife.bsky.social: Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye doi.org/10.7554/eLif...
This is interesting, surprising, and I’m having a hard time getting my head around it…
Several folks reached out to me to ask if the same trends applied to R01s only.
Here are the data:
This is the fraction of "excess" funding from R01s out of the overall R01 funding.
The trend is similar with an even larger increase from FY2024 to FY2025.
1/3
Here are the data:
This is the fraction of "excess" funding from R01s out of the overall R01 funding.
The trend is similar with an even larger increase from FY2024 to FY2025.
1/3
November 4, 2025 at 12:34 PM
This is interesting, surprising, and I’m having a hard time getting my head around it…
Reposted by Adam Gracz
#microsky #mevosky The UNC Chapel Hill Biology Department is hiring 2 Teaching Assistant/Associate Professors with expertise from any area of biology. Individuals with expertise in microbiology are particularly encouraged to apply. Read more and apply at unc.peopleadmin.com/postings/307...
Two (2) Open Rank Teaching Faculty
The Department of Biology at the University of North Carolina at Chapel Hill seeks applicants for two (2) Teaching Faculty positions to be effective July 1, 2026. These positions will be fixed-term 9-...
unc.peopleadmin.com
October 14, 2025 at 1:44 PM
#microsky #mevosky The UNC Chapel Hill Biology Department is hiring 2 Teaching Assistant/Associate Professors with expertise from any area of biology. Individuals with expertise in microbiology are particularly encouraged to apply. Read more and apply at unc.peopleadmin.com/postings/307...
Reposted by Adam Gracz
If you are asking about the mechanics of submitting a NIH grant, as far as I can tell (having put one in during the shutdown) these are accepted and go into Recent/Pending esubmissions as usual. I assume (ymmv) that these will be stuck there in "pending verification" until the gov opens up again.
October 21, 2025 at 9:25 PM
If you are asking about the mechanics of submitting a NIH grant, as far as I can tell (having put one in during the shutdown) these are accepted and go into Recent/Pending esubmissions as usual. I assume (ymmv) that these will be stuck there in "pending verification" until the gov opens up again.
Reposted by Adam Gracz
Number I heard was 164 canceled by end of this week, approximately 12000 applications.
October 21, 2025 at 4:15 PM
Number I heard was 164 canceled by end of this week, approximately 12000 applications.
Reposted by Adam Gracz
Sure - folks will argue any tool that makes this easier is an improvement. But I'd argue it does not make it easier. It emphasizes the armchair science part and diminishes the actual experimental work. Without which the armchair part doesn't have any value. YMMV.
October 20, 2025 at 7:22 PM
Sure - folks will argue any tool that makes this easier is an improvement. But I'd argue it does not make it easier. It emphasizes the armchair science part and diminishes the actual experimental work. Without which the armchair part doesn't have any value. YMMV.
Reposted by Adam Gracz
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Adam Gracz
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
October 12, 2025 at 2:20 PM
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
Reposted by Adam Gracz
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
This 4-year-old's heart is failing. A federal grant that might help him was canceled
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
n.pr
October 12, 2025 at 9:59 PM
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
This is probably one of the coolest and most creative mouse models I’ve ever seen!
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
October 10, 2025 at 3:34 PM
This is probably one of the coolest and most creative mouse models I’ve ever seen!
Reposted by Adam Gracz
I do biomedical research to help people. When people come in this space making things up, it makes it harder for people not in the field to trust the extensive studies that we do and distinguish fact from fiction. Baseless claims reduce future cures. Willful ignorance drives us backwards.
October 9, 2025 at 11:48 PM
I do biomedical research to help people. When people come in this space making things up, it makes it harder for people not in the field to trust the extensive studies that we do and distinguish fact from fiction. Baseless claims reduce future cures. Willful ignorance drives us backwards.
Great department, great institution, wonderful colleagues! This is an outstanding opportunity
My department at Emory is a hiring a tenure-track neuroscientist!
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 30, 2025 at 6:51 PM
Great department, great institution, wonderful colleagues! This is an outstanding opportunity
Reposted by Adam Gracz
My department at Emory is a hiring a tenure-track neuroscientist!
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 30, 2025 at 6:25 PM
My department at Emory is a hiring a tenure-track neuroscientist!
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Anyone who's talked to me in the last 4 years knows I cannot say enough good things about my dept and the neuroscience community here. My colleagues are so wonderfully supportive. Postdocs, please apply!
apply.interfolio.com/174371
Reposted by Adam Gracz
We initiated this open letter yesterday, before the solicitation came out. We made an update this morning, and are working on additional response and actions focused on the eligibility change.
Please sign and share the letter if you can! And add an email for updates.
bsky.app/profile/jaso...
Please sign and share the letter if you can! And add an email for updates.
bsky.app/profile/jaso...
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
jasonjwilliamsny.github.io
September 26, 2025 at 10:51 PM
We initiated this open letter yesterday, before the solicitation came out. We made an update this morning, and are working on additional response and actions focused on the eligibility change.
Please sign and share the letter if you can! And add an email for updates.
bsky.app/profile/jaso...
Please sign and share the letter if you can! And add an email for updates.
bsky.app/profile/jaso...
This was (horrible) news to me. Took a few minutes to sign - you should too!
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
jasonjwilliamsny.github.io
September 25, 2025 at 11:17 PM
This was (horrible) news to me. Took a few minutes to sign - you should too!
Reposted by Adam Gracz
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...