Adam Gracz
@graczlab.bsky.social
Genetic regulation of cell identity and regeneration | All things gut & liver | 🏳️🌈 | Opinions are my own | he/him/his www.graczlab.org
Reposted by Adam Gracz
From Meghan Mott on LinkedIn
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January 20, 2026 at 5:26 PM
From Meghan Mott on LinkedIn
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Reposted by Adam Gracz
The language on multiyear funding (MYF) is ineffective.
Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%.
This is incredibly harmful to the US research workforce - especially early career.
Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%.
This is incredibly harmful to the US research workforce - especially early career.
The final LHHS bill with funding for Health and Human Services is out this morning! At first glance, it looks similar to the Senate bill with a roughly 1% increase in total funding for the NIH. While it doesn't match inflation, it avoids many of the problems in the presidential budget request. 1/n
January 20, 2026 at 3:25 PM
The language on multiyear funding (MYF) is ineffective.
Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%.
This is incredibly harmful to the US research workforce - especially early career.
Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%.
This is incredibly harmful to the US research workforce - especially early career.
Reposted by Adam Gracz
MYF and a 4% budget cut for NIDDK. This is absolutely awful.
Now for the money...
Overall, the budget is essentially flat.
The biggest winner is NINDS with a 5.9% increase. The biggest losers are NIEHS and NIDDK.
4/5
Overall, the budget is essentially flat.
The biggest winner is NINDS with a 5.9% increase. The biggest losers are NIEHS and NIDDK.
4/5
January 20, 2026 at 4:49 PM
MYF and a 4% budget cut for NIDDK. This is absolutely awful.
FINALLY out in AJPath - the second manuscript from @hannahhrncir.bsky.social’s PhD at Emory! Hannah developed a novel pipeline for quantitative 3D light sheet microscopy of bile ducts that will hopefully be a great resource to the community. ajp.amjpathol.org/article/S000...
Quantitative 3D Imaging of Mouse and Human Intrahepatic Bile Ducts in Homeostasis and Liver Injury
Intrahepatic bile ducts (IHBDs) form a complex hierarchical network essential for
liver function. The remodeling and expansion of this network during ductular reaction
(DR) are hallmarks of liver dise...
ajp.amjpathol.org
January 20, 2026 at 11:54 AM
FINALLY out in AJPath - the second manuscript from @hannahhrncir.bsky.social’s PhD at Emory! Hannah developed a novel pipeline for quantitative 3D light sheet microscopy of bile ducts that will hopefully be a great resource to the community. ajp.amjpathol.org/article/S000...
HUGE problem!
It is a PROBLEM that the new MANDATORY ScienCV platform does not (as far as I can tell) enable one to indicate co-first or co-senior authorship in your bibliography. This is a massive disincentive to collaborative science and it needs to be fixed.
January 19, 2026 at 11:29 PM
HUGE problem!
‼️
The appropriations bill that includes NIH is being finalized.
The Senate bill includes a bipartisan amendment from Senators Capito (WV) and Baldwin (WI) limiting multi-year funding of grants.
The House version does not and OMB has issued a veto threat if the House includes such language.
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The Senate bill includes a bipartisan amendment from Senators Capito (WV) and Baldwin (WI) limiting multi-year funding of grants.
The House version does not and OMB has issued a veto threat if the House includes such language.
1/3
a close up of a brown surface with a few spots
ALT: a close up of a brown surface with a few spots
media.tenor.com
January 14, 2026 at 2:01 PM
‼️
Reposted by Adam Gracz
I still think if you have a completed story you believe is ready to submit then there is no disadvantage to pre-printing. We always pre-print first and then decide where to submit. As stressed above this in effect mitigates ‘scooping’. Revision requests in every field have got out of control.
January 13, 2026 at 8:21 AM
I still think if you have a completed story you believe is ready to submit then there is no disadvantage to pre-printing. We always pre-print first and then decide where to submit. As stressed above this in effect mitigates ‘scooping’. Revision requests in every field have got out of control.
Reposted by Adam Gracz
When I was the DGS of an umbrella-type PhD program, I worked to put in a rule that PhD students needed a minimum of one 1st-author research paper to graduate. The main intent was to protect students from advisors that were slackers about publishing. No 1st-author pubs really hurts students. 1/3
January 9, 2026 at 1:44 AM
When I was the DGS of an umbrella-type PhD program, I worked to put in a rule that PhD students needed a minimum of one 1st-author research paper to graduate. The main intent was to protect students from advisors that were slackers about publishing. No 1st-author pubs really hurts students. 1/3
Reposted by Adam Gracz
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 6, 2026 at 11:29 PM
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
Reposted by Adam Gracz
The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o
rdcu.be/eUK3m
rdcu.be/eUK3m
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion - Nature Biotechnology
The suitability of different AAV capsids for gene therapy is assessed in human livers.
go.nature.com
December 16, 2025 at 2:48 AM
The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o
rdcu.be/eUK3m
rdcu.be/eUK3m
Can’t wait for this one!
Get Ready! Mark your calendars for the 22nd edition of the legendary FASEB GI Tract meeting!
Join us at the Snowbird Resort in Utah from August 30 to September 3, 2026.
Join us at the Snowbird Resort in Utah from August 30 to September 3, 2026.
December 11, 2025 at 5:24 PM
Can’t wait for this one!
Reposted by Adam Gracz
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - Nature Biotechnology
Virus-like particles are engineered to edit human hematopoietic cells in vivo.
go.nature.com
December 8, 2025 at 6:53 PM
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
Reposted by Adam Gracz
Great question!
1) First and foremost, we evaluate a candidate based on the departmental guidelines and expectations provided. We don't hold the candidate to arbitrary standards, or even to those of our own institution unless asked to do so. We assess the materials against the guidelines provided.
1) First and foremost, we evaluate a candidate based on the departmental guidelines and expectations provided. We don't hold the candidate to arbitrary standards, or even to those of our own institution unless asked to do so. We assess the materials against the guidelines provided.
Dear senior profs who have written tenure letters.
Can you help demystify the process for some junior profs up for tenure soon?
What do you look for? How do you make your evaluation?
We are told that the letters are the most important part of the file, but not what letter writers look for.
1/
Can you help demystify the process for some junior profs up for tenure soon?
What do you look for? How do you make your evaluation?
We are told that the letters are the most important part of the file, but not what letter writers look for.
1/
December 4, 2025 at 9:17 PM
Great question!
1) First and foremost, we evaluate a candidate based on the departmental guidelines and expectations provided. We don't hold the candidate to arbitrary standards, or even to those of our own institution unless asked to do so. We assess the materials against the guidelines provided.
1) First and foremost, we evaluate a candidate based on the departmental guidelines and expectations provided. We don't hold the candidate to arbitrary standards, or even to those of our own institution unless asked to do so. We assess the materials against the guidelines provided.
Reposted by Adam Gracz
🚨 NIH F31 fellowship Sponsor❓- prior versions of the Sponsor document, there was a table of sponsor's & co-sponsor active or pending awards but this section is gone - should I beef up this area in my sponsor biosketch? Or am I missing where to include this information? Do we do a other support doc?
a batman logo is being projected on a dark background
ALT: a batman logo is being projected on a dark background
media.tenor.com
November 28, 2025 at 5:26 PM
🚨 NIH F31 fellowship Sponsor❓- prior versions of the Sponsor document, there was a table of sponsor's & co-sponsor active or pending awards but this section is gone - should I beef up this area in my sponsor biosketch? Or am I missing where to include this information? Do we do a other support doc?
Reposted by Adam Gracz
Me leaving the lab after seeing bands the right size in my colony PCR gel
Father Ted GIF
ALT: Father Ted GIF
media.tenor.com
November 27, 2025 at 6:46 PM
Me leaving the lab after seeing bands the right size in my colony PCR gel
Reposted by Adam Gracz
Thats 216 biomedical PhD students for their whole degree, or 140 2 year R21 grants, or 30 5 year R01 grants, or one fired football coach...
FIFTY FOUR MILLION DOLLARS, to fire a football coach at a state university
SOURCE: LSU has given Brian Kelly formal written notice that he has been terminated without cause and that it will fulfill the obligation of his nearly $54 million buyout.
November 27, 2025 at 3:45 AM
Thats 216 biomedical PhD students for their whole degree, or 140 2 year R21 grants, or 30 5 year R01 grants, or one fired football coach...
Reposted by Adam Gracz
A tragedy for America tech and biotech.
“Statutory authority for SBIR/STTR lapsed on September 30, 2025, so agencies cannot issue new SBIR/STTR awards or NOFOs until Congress passes an extension or broader reauthorization.”
www.sbir.gov/node
“Statutory authority for SBIR/STTR lapsed on September 30, 2025, so agencies cannot issue new SBIR/STTR awards or NOFOs until Congress passes an extension or broader reauthorization.”
www.sbir.gov/node
| SBIR
www.sbir.gov
November 26, 2025 at 11:39 PM
A tragedy for America tech and biotech.
“Statutory authority for SBIR/STTR lapsed on September 30, 2025, so agencies cannot issue new SBIR/STTR awards or NOFOs until Congress passes an extension or broader reauthorization.”
www.sbir.gov/node
“Statutory authority for SBIR/STTR lapsed on September 30, 2025, so agencies cannot issue new SBIR/STTR awards or NOFOs until Congress passes an extension or broader reauthorization.”
www.sbir.gov/node
Reposted by Adam Gracz
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
Wait this is kind of wild…so there’s a chance that some applications will be funded but ND?
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:03 PM
Wait this is kind of wild…so there’s a chance that some applications will be funded but ND?
Reposted by Adam Gracz
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
November 24, 2025 at 12:59 AM
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Open-Rank, Tenure-Track Faculty Positions, Center for Molecular Medicine
The Center for Molecular Medicine in partnership with Departments of Biochemistry and Biophysics, Cell Biology and Physiology, Genetics, Microbiology and Immunology and Pediatrics at the University of...
unc.peopleadmin.com
November 19, 2025 at 1:45 PM
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Congratulations to Dr. Nic Janto, who defended his PhD in the GMB Program at Emory earlier this week! Nic is headed off to postdoc with Edan Foley at The University of Bath. It’s the end of an era for the lab, but very excited to follow Nic’s journey into zebrafish models of intestinal biology! 🐟
November 19, 2025 at 11:51 AM
Congratulations to Dr. Nic Janto, who defended his PhD in the GMB Program at Emory earlier this week! Nic is headed off to postdoc with Edan Foley at The University of Bath. It’s the end of an era for the lab, but very excited to follow Nic’s journey into zebrafish models of intestinal biology! 🐟
Reposted by Adam Gracz
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown