Niema Moshiri
@niema.net
Associate Teaching Professor of Computer Science at UC San Diego, Bioinformatician by training, SD-raised. https://niema.net
Reposted by Niema Moshiri
Ok — here's the current version of the mim preprint: bit.ly/4pygyyc! Hopefully it will make it to @biorxivpreprint.bsky.social soon, but who knows with the holiday week. Anyway, by the time it hits, we'll probably already have interesting updates to share. Happy to answer questions :).
November 26, 2025 at 9:34 PM
Ok — here's the current version of the mim preprint: bit.ly/4pygyyc! Hopefully it will make it to @biorxivpreprint.bsky.social soon, but who knows with the holiday week. Anyway, by the time it hits, we'll probably already have interesting updates to share. Happy to answer questions :).
Reposted by Niema Moshiri
Lots of people sharing this clip because it's funny and cathartic but I also genuinely believe it's important.
We have to win the narrative battle between "I live in a corrupt society and that's just how it is" and "I live in a corrupt society and we are going to defeat and humiliate these ghouls."
We have to win the narrative battle between "I live in a corrupt society and that's just how it is" and "I live in a corrupt society and we are going to defeat and humiliate these ghouls."
Good morning to Brazilian reporter Manuela Borges, who’s been waiting eleven years for this petty moment. ❤️ 🇧🇷
November 26, 2025 at 4:07 PM
Lots of people sharing this clip because it's funny and cathartic but I also genuinely believe it's important.
We have to win the narrative battle between "I live in a corrupt society and that's just how it is" and "I live in a corrupt society and we are going to defeat and humiliate these ghouls."
We have to win the narrative battle between "I live in a corrupt society and that's just how it is" and "I live in a corrupt society and we are going to defeat and humiliate these ghouls."
Reposted by Niema Moshiri
I have quite literally lived this.
November 24, 2025 at 8:15 PM
I have quite literally lived this.
Reposted by Niema Moshiri
Companies ignore when their employees are harassed because standing up for them could affect their bottom line, because a sect of gamers cherish harassing those they deem other. Ignoring that behavior and then caving to their obscene demands keeps the industry firmly in their claws.
For @aftermath.site, I spoke to @imodrew.bsky.social, the Sucker Punch dev fired after making a Charlie Kirk joke.
She paints a picture of an industry that all too often ignores bad actors until those bad actors threaten them financially.
aftermath.site/sucker-punch...
She paints a picture of an industry that all too often ignores bad actors until those bad actors threaten them financially.
aftermath.site/sucker-punch...
Two Months After Firing Over Charlie Kirk Comments, Ghost Of Yotei Dev Blames Harassment Campaign, Not ‘Bad Joke’
"I really don’t want this to happen to anyone else, because I feel like with the state of everything, it will absolutely happen to other people," says Drew Harrison
aftermath.site
November 24, 2025 at 8:12 PM
Companies ignore when their employees are harassed because standing up for them could affect their bottom line, because a sect of gamers cherish harassing those they deem other. Ignoring that behavior and then caving to their obscene demands keeps the industry firmly in their claws.
Reposted by Niema Moshiri
New Episode!
Challenging the NIH’s new “pandemic playbook” and COVID revisionism.
With the inimitable @angierasmussen.bsky.social & @codyjohnston.bsky.social
iTunes: tinyurl.com/yr4djnmc
Spotify: tinyurl.com/msnmprrm
Challenging the NIH’s new “pandemic playbook” and COVID revisionism.
With the inimitable @angierasmussen.bsky.social & @codyjohnston.bsky.social
iTunes: tinyurl.com/yr4djnmc
Spotify: tinyurl.com/msnmprrm
November 26, 2025 at 3:07 PM
New Episode!
Challenging the NIH’s new “pandemic playbook” and COVID revisionism.
With the inimitable @angierasmussen.bsky.social & @codyjohnston.bsky.social
iTunes: tinyurl.com/yr4djnmc
Spotify: tinyurl.com/msnmprrm
Challenging the NIH’s new “pandemic playbook” and COVID revisionism.
With the inimitable @angierasmussen.bsky.social & @codyjohnston.bsky.social
iTunes: tinyurl.com/yr4djnmc
Spotify: tinyurl.com/msnmprrm
Reposted by Niema Moshiri
Good morning to Brazilian reporter Manuela Borges, who’s been waiting eleven years for this petty moment. ❤️ 🇧🇷
November 26, 2025 at 1:04 PM
Good morning to Brazilian reporter Manuela Borges, who’s been waiting eleven years for this petty moment. ❤️ 🇧🇷
Reposted by Niema Moshiri
Handing back student work that’s been written by ChatGPT with a 0 followed by the comment “This essay will never stand in authentic wonder before the Beauty of God’s creation.”
Pope Leo XIV told students not to use artificial intelligence for homework, saying that AI ‘won’t stand in authentic wonder before the beauty of God’s creation.’
Even God Is Worried About ChatGPT
Pope Leo XIV told students not to use artificial intelligence for homework, saying that AI ‘won’t stand in authentic wonder before the beauty of God’s creation.’
www.vulture.com
November 26, 2025 at 3:35 PM
Handing back student work that’s been written by ChatGPT with a 0 followed by the comment “This essay will never stand in authentic wonder before the Beauty of God’s creation.”
Reposted by Niema Moshiri
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
November 26, 2025 at 12:18 AM
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
Reposted by Niema Moshiri
"It is against the TOS to be talked into suicide by our LLM" is possibly the most evil tech bro thing I've ever read
Additionally, OpenAI argues its not liable because Raine, by using ChatGPT for self-harm, broke its terms of service
November 26, 2025 at 12:29 AM
"It is against the TOS to be talked into suicide by our LLM" is possibly the most evil tech bro thing I've ever read
Reposted by Niema Moshiri
Happy Birthday to the legend and Father of Final Fantasy 🎂🎉🎈❤️
✨Hironobu Sakaguchi✨
✨Hironobu Sakaguchi✨
November 25, 2025 at 11:51 PM
Happy Birthday to the legend and Father of Final Fantasy 🎂🎉🎈❤️
✨Hironobu Sakaguchi✨
✨Hironobu Sakaguchi✨
Just found out I have the same birthday as Hironobu Sakaguchi 😳😍
Happy Birthday to the legend and Father of Final Fantasy 🎂🎉🎈❤️
✨Hironobu Sakaguchi✨
✨Hironobu Sakaguchi✨
November 26, 2025 at 4:14 AM
Just found out I have the same birthday as Hironobu Sakaguchi 😳😍
Reposted by Niema Moshiri
Hey #microbialsky - anyone looking for a good PhD student this cycle? Ugrad from my lab is looking but no luck with the PIs she has contacted (no funding, no response). She worked in my lab for 1.5 years, now is a research tech at the FWC research institute. Excellent at the bench & super smart!
November 26, 2025 at 1:36 AM
Hey #microbialsky - anyone looking for a good PhD student this cycle? Ugrad from my lab is looking but no luck with the PIs she has contacted (no funding, no response). She worked in my lab for 1.5 years, now is a research tech at the FWC research institute. Excellent at the bench & super smart!
Reposted by Niema Moshiri
The first official confirmation that Noem herself made the decision not to turn the planes around. A couple hundred men were tortured as a result — and soon after, the Supreme Court confirmed that the Trump admin’s Alien Enemies Act process was a total violation of due process.
BREAKING:
“After receiving that legal advice, Secretary Noem directed that the AEA detainees who had been removed from the United States before the Court’s order could be transferred to the custody of El Salvador. “
“After receiving that legal advice, Secretary Noem directed that the AEA detainees who had been removed from the United States before the Court’s order could be transferred to the custody of El Salvador. “
November 26, 2025 at 1:45 AM
The first official confirmation that Noem herself made the decision not to turn the planes around. A couple hundred men were tortured as a result — and soon after, the Supreme Court confirmed that the Trump admin’s Alien Enemies Act process was a total violation of due process.
Reposted by Niema Moshiri
With Slorado, now you have more choices for GPUs when basecalling @nanoporetech.com sequencing data. This is a work we collaborated on with AMD, led by
PhD candidate @bonson-wong.bsky.social (poster at #abacbs2025) and great to see being highlighted in the AMD blog: www.amd.com/en/blogs/202...
PhD candidate @bonson-wong.bsky.social (poster at #abacbs2025) and great to see being highlighted in the AMD blog: www.amd.com/en/blogs/202...
www.amd.com
November 26, 2025 at 1:43 AM
With Slorado, now you have more choices for GPUs when basecalling @nanoporetech.com sequencing data. This is a work we collaborated on with AMD, led by
PhD candidate @bonson-wong.bsky.social (poster at #abacbs2025) and great to see being highlighted in the AMD blog: www.amd.com/en/blogs/202...
PhD candidate @bonson-wong.bsky.social (poster at #abacbs2025) and great to see being highlighted in the AMD blog: www.amd.com/en/blogs/202...
Reposted by Niema Moshiri
Reposted by Niema Moshiri
Being among the first interrogated and ultimately fired by DOGE, I certainly felt we were facing the business end of a right-wing conspiracy theory 🧵
DOGE was not a money-saving effort. It was an effort to chase down and prove right-wing conspiracy theories. They went after USAID to prove conspiracy theories about foreign aid. Then they went after SSA to, again, pursue conspiracy theories about Dems paying "illegals" to vote. 1/2
All DOGE accomplished was purging critical government staff, handing private data to outsiders, and sentencing thousands in developing countries to death by gutting USAID.
I don’t say this lightly: if there were any justice in this world, the people responsible for this devastation would be in jail
I don’t say this lightly: if there were any justice in this world, the people responsible for this devastation would be in jail
November 26, 2025 at 2:31 AM
Being among the first interrogated and ultimately fired by DOGE, I certainly felt we were facing the business end of a right-wing conspiracy theory 🧵
Reposted by Niema Moshiri
Installed an internal BlueSCSI hard drive in my Mac LCIII tonight. I bought the BS at VCF-MW in Sep from @museumjoe.bsky.social. Decided to play a little Sim City #mac #macintosh #retrocomputing Thanks @bluescsi.com!
November 26, 2025 at 3:00 AM
Installed an internal BlueSCSI hard drive in my Mac LCIII tonight. I bought the BS at VCF-MW in Sep from @museumjoe.bsky.social. Decided to play a little Sim City #mac #macintosh #retrocomputing Thanks @bluescsi.com!
Reposted by Niema Moshiri
President Donald Trump’s chief envoy with the Russian government advised a senior aide to Vladimir Putin on how the Russian leader should pitch the U.S. president on a Ukraine peace plan favorable to Russia, according to a transcript of the call published by Bloomberg News.
US Envoy Coached Putin Aide on How Russian Leader Could Sell Trump on Peace Plan That Favors Russia
A U.S. envoy advised a senior aide to Vladimir Putin on how Putin should go about pitching Trump on a Russia-friendly Ukraine peace plan.
www.mississippifreepress.org
November 26, 2025 at 3:00 AM
President Donald Trump’s chief envoy with the Russian government advised a senior aide to Vladimir Putin on how the Russian leader should pitch the U.S. president on a Ukraine peace plan favorable to Russia, according to a transcript of the call published by Bloomberg News.
Reposted by Niema Moshiri
Exciting things are happening over in @funfactorpod.com world!
November 26, 2025 at 3:04 AM
Exciting things are happening over in @funfactorpod.com world!
Reposted by Niema Moshiri
#Zaparoo Core v2.7.0 is now out! Massive release with new platforms, new readers, new launcher and QoL features on every platform. Lots of fun stuff to play with. Check it out!
zaparoo.org/blog/core-v2...
zaparoo.org/blog/core-v2...
Zaparoo Core v2.7.0 released | Zaparoo
Zaparoo Core v2.7.0 is now available! This is a massive release with some fundamental improvements to how Zaparoo works. Title IDs are now the default way to identify games, making your tokens portabl...
zaparoo.org
November 25, 2025 at 11:58 AM
#Zaparoo Core v2.7.0 is now out! Massive release with new platforms, new readers, new launcher and QoL features on every platform. Lots of fun stuff to play with. Check it out!
zaparoo.org/blog/core-v2...
zaparoo.org/blog/core-v2...
Reposted by Niema Moshiri
“We’ve tried to not have to do it, but we've got direct orders,” the masked ICE agents told them www.nbcsandiego.com/news/local/i...
November 25, 2025 at 12:26 PM
“We’ve tried to not have to do it, but we've got direct orders,” the masked ICE agents told them www.nbcsandiego.com/news/local/i...
Reposted by Niema Moshiri
Delete Twitter, the fascist propaganda site.
As soon as this new information was unleashed, people began looking at the location data for accounts that primarily serve to stoke political tensions in the U.S. with far-right narratives that are often misleading or outright false.
X's Top MAGA Trolls Revealed to Be Foreign Accounts
bit.ly
November 25, 2025 at 2:18 PM
Delete Twitter, the fascist propaganda site.
Reposted by Niema Moshiri
eXoWin9x was just launched and it's both the best way to play Windows 95 & 08 games on your modern PC, as well as the best PC game preservation effort I've seen. Details and links in the post, but holy crap, don't skip this one!!!:
retrorgb.com/exowin9x-lau...
retrorgb.com/exowin9x-lau...
eXoWin9x – Launch Windows 98 Games Like ROMs - RetroRGB
https://youtu.be/OJrC5YdB6hk eXo has just released "eXoWin9x" - a 262GB preservation project of Windows 95 and 98 games that are each configured to run like a "ROM". They're all configured to run via ...
retrorgb.com
November 25, 2025 at 2:41 PM
eXoWin9x was just launched and it's both the best way to play Windows 95 & 08 games on your modern PC, as well as the best PC game preservation effort I've seen. Details and links in the post, but holy crap, don't skip this one!!!:
retrorgb.com/exowin9x-lau...
retrorgb.com/exowin9x-lau...
Reposted by Niema Moshiri
SEN. KELLY : “They informed me of this in a tweet because this is not about the law. This is about the media cycle, and intimidation… We basically repeated the uniform code of military justice, and they're saying that's in violation of it. It's absurd. Comical.”
November 25, 2025 at 3:15 AM
SEN. KELLY : “They informed me of this in a tweet because this is not about the law. This is about the media cycle, and intimidation… We basically repeated the uniform code of military justice, and they're saying that's in violation of it. It's absurd. Comical.”
Reposted by Niema Moshiri
Ok; mim (github.com/COMBINE-lab/...) preprint submitted! Excited for folks to see it and share thoughts. The key takeaway; mim allows the quick, one-time, building of a small auxiliary index that then allows scaling gzipped FASTQ parsing linearly in # of threads. 1/2
GitHub - COMBINE-lab/mim: A small, auxiliary index to massively improve parallel fastq parsing
A small, auxiliary index to massively improve parallel fastq parsing - COMBINE-lab/mim
github.com
November 25, 2025 at 2:13 PM
Ok; mim (github.com/COMBINE-lab/...) preprint submitted! Excited for folks to see it and share thoughts. The key takeaway; mim allows the quick, one-time, building of a small auxiliary index that then allows scaling gzipped FASTQ parsing linearly in # of threads. 1/2