Oleg Ko
@okolupaev.bsky.social
A life sciences researcher, flow cytometry enthusiast, and F1 fan (no team allegiances). Running curious
This summary is exactly what you need to know about todays Nobel prize winners and their contributions to our understanding of the immune system
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 12:38 PM
This summary is exactly what you need to know about todays Nobel prize winners and their contributions to our understanding of the immune system
I am just catching up on Friday’s Marketplace…@kairyssdal.bsky.social is says that he’s been hosting the program for 20 years! That makes me a listener for the last 17. Started during the 2008 financial crisis, after just making a move to the US for grad school. Thank you Kai for all these years!
August 4, 2025 at 1:26 PM
I am just catching up on Friday’s Marketplace…@kairyssdal.bsky.social is says that he’s been hosting the program for 20 years! That makes me a listener for the last 17. Started during the 2008 financial crisis, after just making a move to the US for grad school. Thank you Kai for all these years!
Some personal highlights from #CYTO2025:
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications
June 7, 2025 at 2:05 AM
Some personal highlights from #CYTO2025:
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications
Full house for the spectral flow cytometry session at #CYTO2025. Great news! This session is going to be recorded and available to view later!
May 31, 2025 at 5:32 PM
Full house for the spectral flow cytometry session at #CYTO2025. Great news! This session is going to be recorded and available to view later!
This is true on so many levels! It takes time to pick the right reference controls, it definitely worth a few extra minutes to run them at a slower speed. #flowcytometry
Today's tip: when running your single-color controls, take it slow. The tortoise, as it turns out, beats the hare for spectral flow cytometry.
www.colibri-cytometry.com/post/unmixin...
www.colibri-cytometry.com/post/unmixin...
Unmixing: the tortoise beats the hare
Today's tip: when running your single-color controls, take it slow.
www.colibri-cytometry.com
March 31, 2025 at 11:26 PM
This is true on so many levels! It takes time to pick the right reference controls, it definitely worth a few extra minutes to run them at a slower speed. #flowcytometry
Reposted by Oleg Ko
Review @natimmunol.bsky.social
B cell immunometabolism in health and disease
www.nature.com/articles/s41...
B cell immunometabolism in health and disease
www.nature.com/articles/s41...
B cell immunometabolism in health and disease - Nature Immunology
In this Review, Matarese and colleagues discuss how immunometabolism controls the physiology and pathophysiology of B cells.
www.nature.com
February 21, 2025 at 5:15 PM
Review @natimmunol.bsky.social
B cell immunometabolism in health and disease
www.nature.com/articles/s41...
B cell immunometabolism in health and disease
www.nature.com/articles/s41...
Reposted by Oleg Ko
FGF21 keeps the thymus young @natureaging.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social
FGF21 keeps the thymus young - Nature Aging
Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now i...
www.nature.com
February 19, 2025 at 6:44 PM
FGF21 keeps the thymus young @natureaging.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social
Reposted by Oleg Ko
In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
www.science.org
January 27, 2025 at 4:49 PM
In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.
Reposted by Oleg Ko
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
January 27, 2025 at 11:26 PM
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
Reposted by Oleg Ko
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT https://www.biorxiv.org/content/10.1101/2025.01.16.633453v1
January 22, 2025 at 1:18 AM
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT https://www.biorxiv.org/content/10.1101/2025.01.16.633453v1
Reposted by Oleg Ko
I am hiring for a postdoctoral fellow at UNC Chapel Hill in Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). The successful candidate will work on my NIH funded program of research on suicide risk among preteens. Please share. Deadline 1/31! unc.peopleadmin.com/postings/290...
Post-Doc Research Associate
The selected candidate will engage in a combination of clinical research activities aligned with a NIMH funded R01 within the Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). Clinical...
unc.peopleadmin.com
January 21, 2025 at 3:32 PM
I am hiring for a postdoctoral fellow at UNC Chapel Hill in Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). The successful candidate will work on my NIH funded program of research on suicide risk among preteens. Please share. Deadline 1/31! unc.peopleadmin.com/postings/290...
Important resource! There is a tendency to treat children as miniature versions of adults.
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine
New paper alert 📢! (Cell) @cp-cell.bsky.social
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
January 22, 2025 at 2:07 AM
Important resource! There is a tendency to treat children as miniature versions of adults.
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine
We are one step closer to the HIV vaccine. Great job, DHVI! #HIV #vaccines www.science.org/doi/10.1126/...
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations
An immunogen engineered by computational and structure-based methods activated diverse B cell precursors and induced rare mutations in mouse models.
www.science.org
January 20, 2025 at 5:52 PM
We are one step closer to the HIV vaccine. Great job, DHVI! #HIV #vaccines www.science.org/doi/10.1126/...
Reposted by Oleg Ko
@ImmunityCP preview:
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Restimulation by macrophages exhausts T cells
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this
issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating
terminal T cell exhaustio...
www.cell.com
January 14, 2025 at 8:42 PM
@ImmunityCP preview:
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Reposted by Oleg Ko
icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
January 15, 2025 at 3:11 AM
icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Oleg Ko
New in Science Magazine this week: two research articles and a Perspective describing synthetic biology gene circuitry for bespoke cellular function - in this case applied to T cells!
Research:
buff.ly/41pkAAb
buff.ly/41gMxu0
Perspective
buff.ly/3ZFUUy8
@science.org
Research:
buff.ly/41pkAAb
buff.ly/41gMxu0
Perspective
buff.ly/3ZFUUy8
@science.org
Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease.
Learn more in this week's issue: scim.ag/49nfztS
Learn more in this week's issue: scim.ag/49nfztS
December 6, 2024 at 9:52 AM
New in Science Magazine this week: two research articles and a Perspective describing synthetic biology gene circuitry for bespoke cellular function - in this case applied to T cells!
Research:
buff.ly/41pkAAb
buff.ly/41gMxu0
Perspective
buff.ly/3ZFUUy8
@science.org
Research:
buff.ly/41pkAAb
buff.ly/41gMxu0
Perspective
buff.ly/3ZFUUy8
@science.org
Reposted by Oleg Ko
Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance: https://www.jci.org/articles/view/186547
Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)
Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)
December 6, 2024 at 2:09 PM
Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance: https://www.jci.org/articles/view/186547
Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)
Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)
Reposted by Oleg Ko
#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
a close up of a woman 's face with a surprised look on her face .
ALT: a close up of a woman 's face with a surprised look on her face .
media.tenor.com
December 5, 2024 at 4:49 PM
#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
Even more reasons to migrate to BlueSky
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 4, 2024 at 1:48 AM
Even more reasons to migrate to BlueSky
A good reminder that fluorescent protein (FP) labels can affect the interaction of the tagged protein with other molecules depending on on the nature of FP and its position ( C- vs N- terminus)
Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:
Fluorescent Tags Are Basically Never Silent
www.science.org
December 3, 2024 at 8:13 PM
A good reminder that fluorescent protein (FP) labels can affect the interaction of the tagged protein with other molecules depending on on the nature of FP and its position ( C- vs N- terminus)
Reposted by Oleg Ko
Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:
Fluorescent Tags Are Basically Never Silent
www.science.org
December 2, 2024 at 6:56 PM
Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:
Reposted by Oleg Ko
Ok, this did it. This told me that BlueSky is doing something right.
Hello everyone.
www.semafor.com/article/11/2...
Hello everyone.
www.semafor.com/article/11/2...
Bluesky boom worries Chinese media | Semafor
State outlets, which put considerable resources into amassing millions of followers on Elon Musk’s social media platform, have recently seen their growth plateau.
www.semafor.com
November 26, 2024 at 4:58 PM
Ok, this did it. This told me that BlueSky is doing something right.
Hello everyone.
www.semafor.com/article/11/2...
Hello everyone.
www.semafor.com/article/11/2...
My favorite resources from Twitter are slowly coming to BlueSky!
Hi Bluesky and #biosky community! Endpoints News is officially on Bluesky, and we'll have more to say soon!
November 27, 2024 at 3:11 PM
My favorite resources from Twitter are slowly coming to BlueSky!