Phil Biggin
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philbiggin.bsky.social
Phil Biggin
@philbiggin.bsky.social
830 followers 320 following 56 posts
Computational biochemist, interested in neuronal signalling at the atomic level and computer-aided drug design. All views my own.

bigginlab.web.ox.ac.uk
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Reposted by Phil Biggin
bioexcelcoe.bsky.social
⏰ Don't forget to register for our #webinar tomorrow, 17 February 2026, 15:00 CET
✍️ bioexcel.eu/7c2s

"From quick script to reproducible workflow"

#molecularsimulations #workflows #FAIR #SoftwareEngineering

@coderefinery.org
Webinar: From Quick Script to Reproducible Workflow: Small Research Software Engineering Habits, Big Impact (2026-02-17)
Date: 17 February 2026 Time: 15:00 CET Registration Abstract Reproducible analysis pipelines sound great in theory, but what does that look like in the life of a busy researcher doing biomolecular sy...
bioexcel.eu
February 16, 2026 at 3:19 PM
Reposted by Phil Biggin
biophysj.bsky.social
#OPENACCESS: Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A. Deepesh Sigdel and Maria Mills. buff.ly/GZXDTzi
Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A
Type 1A topoisomerases relax torsional strain in DNA via a strand passage mechanism in which a protein-mediated DNA gate must open during the enzyme’s catalytic cycle. This gate-open conformational…
buff.ly
February 16, 2026 at 7:02 PM
Reposted by Phil Biggin
sbnblab.bsky.social
🚀 JOB OPPORTUNITY: Research Associate in GenAI applied to Drug Discovery! 🧬

Full details: recruitment.irbbarcelona.org/jobs/6928145...
Research Associate on genAI applied to drug discovery (ref. PD/25/23) - IRB Barcelona
IRB Barcelona is seeking a talented and highly motivated Research Associate to join the Structural Bioinformatics and Network Biology group (https://sbnb.irbbarcelona.org), led by Dr. Patrick Aloy,...
recruitment.irbbarcelona.org
February 16, 2026 at 1:02 PM
Reposted by Phil Biggin
susanfjw.bsky.social
There's still time to make a 16 February poster abstract deadline for the Molecular and ion flows #FaradayDiscussion, Manchester, 13-15 April 2026. Poster presenters can expect lively discussions, networking, and a collaborative atmosphere where every delegate can contribute. #ChemSky #Nanofluidics
rsc.org Royal Society of Chemistry @rsc.org · 12d
Could your research drive the conversation at our molecular and ion flow discussion?

There’s still time to join our Faraday Discussion #FD_Channels. ➡️ Poster abstract deadline is now 📆 16 February. Present your results, discuss with your community: rsc.li/channels-fd2026 #ChemSky
Royal Society of Chemistry advertisement for a Faraday Discussions event titled "Molecular and ion flows through angstrom-scale channels." Scheduled for 13-15 April 2026 in Manchester, UK. Poster abstract extension deadline is 16 February 2026. Features colourful molecular structures on a curved path.
February 13, 2026 at 6:07 PM
Reposted by Phil Biggin
pjballester.bsky.social
Our new preprint. First prospective use of a transformer model for drug repurposing against Streptococcus pneumoniae, a major AMR threat. Great collaboration with Nick Croucher’s lab. Of 11 tested, 9 showed strong activity, some against multidrug‑resistant strains.
#AI #AMR
February 16, 2026 at 11:42 AM
Reposted by Phil Biggin
rolanddunbrack.bsky.social
Second time this month I've encountered a paper on MD simulations of protein kinases with no coordinates from the trajectory provided. I'd like a few snapshots or cluster centroids. Something.

Makes these papers essentially useless.
February 14, 2026 at 5:57 AM
philbiggin.bsky.social
Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social

where we show the interplay between the orthosteric and allosteric binding sites.

www.science.org/doi/10.1126/...
Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist
Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.
www.science.org
February 14, 2026 at 8:24 AM
Reposted by Phil Biggin
chemjobber.bsky.social
Takeda (Boston, MA) looking for Associate Director, Computational Chemistry, (PhD, 7+ yrs exp): jobs.takeda.com/job/boston/a... #chemjobs #compchem

(position pretty old, Nov 2025 posting)
Associate Director, Computational Chemistry at Takeda Pharmaceutical
Learn more about applying for Associate Director, Computational Chemistry at Takeda Pharmaceutical
jobs.takeda.com
February 12, 2026 at 8:34 PM
Reposted by Phil Biggin
matthchavent.bsky.social
Happy that simulations, performed by Gabriel Diaz, stellar master student in the team, helped to decipher how PIP2 lipids help recruiting Munc13 protein to prime synaptic vesicle Collaborative work led by F. Pincet @normalesup.bsky.social

full story at @pnas.org : www.pnas.org/doi/10.1073/...
February 12, 2026 at 9:08 AM
Reposted by Phil Biggin
lorraine-reese.bsky.social
Registration is open for the 7th UK Workshop on Membrane #Proteins! Join us from 15-17 April to understand the basics of membrane protein purification using cutting edge methods. Places are limited, save £50 with our earlybird discount if you register before 15 February: ow.ly/rx0B50YbAUt
In-person training. 7th UK Workshop on Membrane Proteins. Birmingham, UK. 15-17 April 2026. Includes Biochemical Society logo, image of scientists in lab coats, in a lab, and event logo.
February 10, 2026 at 9:50 AM
Reposted by Phil Biggin
hallben.bsky.social
Inspiring computational #cancer careers session yesterday with speakers from J&J and AZ!

Interested in the field? On Friday I’m giving a lecture to introduce our new MSc Computational Cancer. Register below:

www.ucl.ac.uk/engineering/...
Photo of panel discussion from our careers event, with Lizzie Coker (AZ), Marta Polak (J&J), and Ben Hall (UCL)
February 11, 2026 at 3:37 PM
philbiggin.bsky.social
Congratulations Beatrix!
February 11, 2026 at 10:19 AM
philbiggin.bsky.social
something to digest... ;-)
lindorfflarsen.bsky.social Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 7d
Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system

Announcement:
www.isomorphiclabs.com/articles/the...

Report:
storage.googleapis.com/isomorphicla...
February 10, 2026 at 5:26 PM
Reposted by Phil Biggin
compbiophys.bsky.social
📩 Join our interdisciplinary team as #PhD student or #postdoc and contribute to the project "Theory and #Algorithms for Structure Determination from Single Molecule X-Ray Scattering Images", a new route to the structure determination of biomolecules. #job #XFEL in #Göttingen 🇩🇪
@mpi-nat.bsky.social
February 10, 2026 at 8:15 AM
Reposted by Phil Biggin
lorneproteins.bsky.social
Session 7 ⚡️🌩 talks time!! Jack Zeng Unravelling Promiscuity - OCT1 gating - structures of ligand bound states. Interrogating binding and transport specificity and mechanism.

#lorneproteins2026
February 10, 2026 at 12:13 AM
philbiggin.bsky.social
Cool…!
ciarawallis.bsky.social Ciara Wallis @ciarawallis.bsky.social · 9d
🥳So excited to announce our latest preprint on PfFNT!! The lactate/H+ exporter from the malaria parasite that challenges the standard definitions of transporters vs channels 💪✨ 1/6
tiny.cc/pffnt
February 9, 2026 at 5:51 PM
Reposted by Phil Biggin
martinrsmith.bsky.social
There's a risk UK participation rates in Horizon Pillar II becoming a self-fulfilling prophecy - the more we create fresh uncertainty about future participation because of low success, the more we disrupt potential collaboration.

So maybe... let's not do that?
February 9, 2026 at 5:27 PM
philbiggin.bsky.social
With @jdcolburn.bsky.social !
February 9, 2026 at 5:00 PM
philbiggin.bsky.social
Check out our latest review of advanced sampling of membrane transporter dynamics - link.springer.com/chapter/10.1...

Great work from Jon Colburn and @simonlichtinger.bsky.social !
Advanced Computational Methods in Protein Simulations: A Case Study of Enhanced Sampling Applied to Membrane Transporters
We review the use of state-of-the-art enhanced sampling techniques in molecular dynamics (MD) simulations. We briefly introduce the principles and practical considerations underlying the application o...
link.springer.com
February 8, 2026 at 10:01 PM
Reposted by Phil Biggin
bioexcelcoe.bsky.social
Learn how to get the most out of your #moleculardynamics simulations with #GROMACS

Register for our #webinar

🗓️ 17 March 2026, 15:00 CET
✍️ bioexcel.eu/oryy

#compchem
February 6, 2026 at 1:44 PM
Reposted by Phil Biggin
elife.bsky.social
Lipids challenge ligands to control receptors

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

🔗 buff.ly/G1Zl6cZ
February 6, 2026 at 2:59 PM
Reposted by Phil Biggin
oxfordbiochemistry.bsky.social
Yesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."
Raymond stands at the centre of the picture next to the entrance to the seminar room. He is surrounded by five family members including his wife.
February 6, 2026 at 2:29 PM
philbiggin.bsky.social
Er…
February 3, 2026 at 10:42 PM
Reposted by Phil Biggin
pssalgado.bsky.social
#UKsciencefundingcrisis MRC,BBSRC,EPSRC paused researcher-led grants until Spring. This means no funds in 2026 as evaluation takes 6-9 months. Projects halted, staff, knowledge loss. We need to challenge this and the lack of info and clarity. #ScienceisVital #academicSky
shorturl.at/ag03S
UK science funding is currently facing a profound crisis, particularly for Life Sciences. Medical Research Council and BBSRC have paused researcher-led grant applications until the Spring, with no… | ...
UK science funding is currently facing a profound crisis, particularly for Life Sciences. Medical Research Council and BBSRC have paused researcher-led grant applications until the Spring, with no cle...
www.linkedin.com
January 31, 2026 at 2:23 PM
Reposted by Phil Biggin
bioexcelcoe.bsky.social
Interested in best practices for creating and maintaining reproducible workflows for biomolecular simulations?

Join us for our #webinar

🗓️ 17 February 2026, 15:00 CET
✍️ bioexcel.eu/7c2s

#molecularsimulations #workflows #FAIR #SoftwareEngineering

@coderefinery.org
January 29, 2026 at 8:52 AM