PlessLab
@plesslab.bsky.social
Ion channels, biophysics, chemical biology, protein engineering and molecular neuroscience; Professor at University of Copenhagen; www.theplesslab.com
To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026:
network.febs.org/posts/new-jo...
Further details to come soon.
Please share and repost.
network.febs.org/posts/new-jo...
Further details to come soon.
Please share and repost.
November 26, 2025 at 4:17 PM
To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026:
network.febs.org/posts/new-jo...
Further details to come soon.
Please share and repost.
network.febs.org/posts/new-jo...
Further details to come soon.
Please share and repost.
Reposted by PlessLab
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
November 23, 2025 at 12:27 AM
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
Reposted by PlessLab
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 2:46 PM
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Very grateful to have been able to attend the second-ever NALCN conference. This provided a fantastic opportunity to catch up with collaborators and meet patients and families affected by NALCN-related diseases. Huge thanks to everyone at the Channeling Hope Foundation for making this event happen!
October 13, 2025 at 3:24 PM
Very grateful to have been able to attend the second-ever NALCN conference. This provided a fantastic opportunity to catch up with collaborators and meet patients and families affected by NALCN-related diseases. Huge thanks to everyone at the Channeling Hope Foundation for making this event happen!
Reposted by PlessLab
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 9:55 PM
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!
September 29, 2025 at 5:26 AM
When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!
After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 17, 2025 at 3:30 PM
After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by PlessLab
Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions!
🔗 Register here: www.lorneproteins.org/register
🔗 Register here: www.lorneproteins.org/register
September 16, 2025 at 12:57 AM
Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions!
🔗 Register here: www.lorneproteins.org/register
🔗 Register here: www.lorneproteins.org/register
Reposted by PlessLab
Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
September 6, 2025 at 4:56 AM
Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.
Reposted by PlessLab
Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/...
#Evolution #IonChannels
#Evolution #IonChannels
September 5, 2025 at 6:15 PM
Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/...
#Evolution #IonChannels
#Evolution #IonChannels
Reposted by PlessLab
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
September 1, 2025 at 11:14 AM
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills
August 22, 2025 at 5:19 PM
Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills
Reposted by PlessLab
🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
August 21, 2025 at 4:38 AM
🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞
February 8–12, 2026
Register here: www.lorneproteins.org
Reposted by PlessLab
Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...
Prevalence of errors in lab-made plasmids across the globe
Abstract. Plasmids are indispensable in life sciences research and therapeutics development. Currently, most labs custom-build their plasmids. As yet, no s
academic.oup.com
August 15, 2025 at 3:56 PM
Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...
Reposted by PlessLab
Villum Sabbatical grant:
For US-based researchers wishing to visit a Danish university for up to 12 months
Deadline Aug. 15th 2025
villumfonden.dk/en/group/cha...
For US-based researchers wishing to visit a Danish university for up to 12 months
Deadline Aug. 15th 2025
villumfonden.dk/en/group/cha...
August 6, 2025 at 7:59 PM
Villum Sabbatical grant:
For US-based researchers wishing to visit a Danish university for up to 12 months
Deadline Aug. 15th 2025
villumfonden.dk/en/group/cha...
For US-based researchers wishing to visit a Danish university for up to 12 months
Deadline Aug. 15th 2025
villumfonden.dk/en/group/cha...
Reposted by PlessLab
🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
August 3, 2025 at 8:21 PM
🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen
Come work with a great team and exciting projects in a collaborative environment!
🔗 Links to the ads in comments
#CryoEM #AcademicJobs
Reposted by PlessLab
@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...
July 16, 2025 at 4:30 PM
@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...
Reposted by PlessLab
We are hiring at the Department of Drug Design and Pharmacology.
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.
employment.ku.dk/faculty/?sho...
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.
employment.ku.dk/faculty/?sho...
164291 Associate Professor or Professor
employment.ku.dk
July 8, 2025 at 12:52 PM
We are hiring at the Department of Drug Design and Pharmacology.
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.
employment.ku.dk/faculty/?sho...
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.
employment.ku.dk/faculty/?sho...
“It’s the company that matters!”
This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1
All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social
www.biorxiv.org/cgi/content/...
This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1
All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social
www.biorxiv.org/cgi/content/...
July 6, 2025 at 10:02 AM
“It’s the company that matters!”
This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1
All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social
www.biorxiv.org/cgi/content/...
This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1
All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social
www.biorxiv.org/cgi/content/...
Reposted by PlessLab
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:08 AM
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Exciting news for protein design!
New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson
Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology
novonordiskfonden.dk/en/news/new-...
Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology
novonordiskfonden.dk/en/news/new-...
New Danish research centre to make designed proteins with vast potential - Novo Nordisk Fonden
novonordiskfonden.dk
June 25, 2025 at 7:26 AM
Exciting news for protein design!
Reposted by PlessLab
I guess I should re-post from the Bird Site "The Rules For Academic Success here":
I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...
This list gets longer all the time
I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...
This list gets longer all the time
August 1, 2023 at 6:30 PM
I guess I should re-post from the Bird Site "The Rules For Academic Success here":
I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...
This list gets longer all the time
I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...
This list gets longer all the time
Reposted by PlessLab
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available.
! Please share widely !
June 5, 2025 at 8:36 PM
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available.
! Please share widely !
Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up:
www.asic-meeting.org
www.asic-meeting.org
ASIC 2025 Meeting - Wissenschaftliches Treffen über ASICs
Erleben Sie die neuesten Fortschritte in der ASIC-Forschung beim ASIC 2025 Meeting in Tutzing.
www.asic-meeting.org
June 3, 2025 at 4:55 PM
Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up:
www.asic-meeting.org
www.asic-meeting.org
Reposted by PlessLab
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!