SusanK
@susankleinfelter.bsky.social
Protein folding nerd, curmudgeon, UW IPD. She/her.
Reposted by SusanK
"This future cannot come fast enough,” says Seattle Hub's Jesse Gray.
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
November 27, 2025 at 12:19 AM
"This future cannot come fast enough,” says Seattle Hub's Jesse Gray.
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
"We are realizing a revolution in programming biology that has incredible potential."
https://brotmanbaty.org/news/seattle-hubs-sense-team-plays-pivotal-role-building-technologies-to-record
Reposted by SusanK
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
November 26, 2025 at 3:06 PM
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Reposted by SusanK
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
November 25, 2025 at 3:01 AM
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
Reposted by SusanK
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
November 25, 2025 at 1:59 AM
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
Reposted by SusanK
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:56 PM
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
Reposted by SusanK
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted by SusanK
Oh my gosh. This is... A thing. Please allow a microbiologist who has played with the microbe that makes this to waffle on for a bit in a short thread. (1)
British and Australian chemists have discovered a powerful new antibiotic called pre-methylenomycin C lactone, hiding in a well-known soil bacterium. This molecule kills drug-resistant bacteria without triggering resistance. buff.ly/YlXaONo
#ShareGoodNewsToo
#ShareGoodNewsToo
Scientists find hidden antibiotic 100x stronger against deadly superbugs
A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It…
buff.ly
November 16, 2025 at 8:02 PM
Oh my gosh. This is... A thing. Please allow a microbiologist who has played with the microbe that makes this to waffle on for a bit in a short thread. (1)
Reposted by SusanK
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
Clathrin adaptors drive phase separation in endocytosis and trafficking
Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize cellular processes, including endocytosis and membrane trafficking. Although LLPS has been impli...
www.biorxiv.org
November 21, 2025 at 10:13 AM
New preprint out!📃
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.
@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social
👉 www.biorxiv.org/content/10.1...
Reposted by SusanK
“It would be a senseless act of cruelty to kill the poor spider just because of my irrational fear,” Hapworth explained. “But obviously I’m not going anywhere near the horrible fucking thing.”
Autistic woman who won’t hurt spider gives it exclusive use of kitchen instead
An autistic woman has surrendered use of her kitchen after finding a spider on the linoleum floor, sources have revealed. Beth Hapworth, 32, reports that she was too frightened to move the spider…
thedailytism.com
November 22, 2025 at 10:01 AM
“It would be a senseless act of cruelty to kill the poor spider just because of my irrational fear,” Hapworth explained. “But obviously I’m not going anywhere near the horrible fucking thing.”
Reposted by SusanK
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
November 17, 2025 at 5:39 PM
If you'd like to celebrate the biology of viruses - or the fight against viral diseases - this winter, try out our free and updated #VirusSnowflake designs.
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Please share, and if you have any photos of Virus Snowflakes in your area it would be lovely to see them!
cvr-engagement.co.uk/virus-snowfl...
Reposted by SusanK
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome
Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and stat...
doi.org
November 19, 2025 at 10:43 AM
Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.
Read more:
Reposted by SusanK
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by SusanK
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by SusanK
Insanely cool discovery!
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 19, 2025 at 6:13 AM
Insanely cool discovery!
Reposted by SusanK
Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:39 PM
Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by SusanK
New @science.org study from @ardemp.bskyverified.social’s lab, co-authored by @yunxiao-dr.bsky.social, shows how PIEZO proteins sense stretch and pressure in the uterus to help coordinate labor, while connexin 43 synchronizes muscle activity across cells.
Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth
www.scripps.edu
November 17, 2025 at 6:43 PM
New @science.org study from @ardemp.bskyverified.social’s lab, co-authored by @yunxiao-dr.bsky.social, shows how PIEZO proteins sense stretch and pressure in the uterus to help coordinate labor, while connexin 43 synchronizes muscle activity across cells.
Reposted by SusanK
In this excerpt from my interview with Mariame Kaba, I talk about how avoidance is a reasonable response to a coercive society, but also can get in our way when it becomes a habit.
Watch the whole episode on Youtube or listen wherever you get your podcasts.
Watch the whole episode on Youtube or listen wherever you get your podcasts.
November 17, 2025 at 4:33 PM
In this excerpt from my interview with Mariame Kaba, I talk about how avoidance is a reasonable response to a coercive society, but also can get in our way when it becomes a habit.
Watch the whole episode on Youtube or listen wherever you get your podcasts.
Watch the whole episode on Youtube or listen wherever you get your podcasts.
Reposted by SusanK
THIS IS HUGE! Researchers have just identified a powerful new antibiotic that is 100x STRONGER than existing drugs against deadly superbugs like MRSA and VRE. Hiding in a well-known soil bacterium, pre-methylenomycin C lactone KILLS drug-resistant bacteria WITHOUT triggering resistance.
November 16, 2025 at 7:30 PM
THIS IS HUGE! Researchers have just identified a powerful new antibiotic that is 100x STRONGER than existing drugs against deadly superbugs like MRSA and VRE. Hiding in a well-known soil bacterium, pre-methylenomycin C lactone KILLS drug-resistant bacteria WITHOUT triggering resistance.
Reposted by SusanK
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by SusanK
I WANT TO HOST ONE OF THESE
props to WSJ for once on a useful notion, ADMIN PARTY for everybody
November 15, 2025 at 5:29 PM
I WANT TO HOST ONE OF THESE
Reposted by SusanK
British and Australian chemists have discovered a powerful new antibiotic called pre-methylenomycin C lactone, hiding in a well-known soil bacterium. This molecule kills drug-resistant bacteria without triggering resistance. buff.ly/YlXaONo
#ShareGoodNewsToo
#ShareGoodNewsToo
Scientists find hidden antibiotic 100x stronger against deadly superbugs
A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It…
buff.ly
November 16, 2025 at 2:50 PM
British and Australian chemists have discovered a powerful new antibiotic called pre-methylenomycin C lactone, hiding in a well-known soil bacterium. This molecule kills drug-resistant bacteria without triggering resistance. buff.ly/YlXaONo
#ShareGoodNewsToo
#ShareGoodNewsToo
Reposted by SusanK
Saturday mornings are ideal for contemplating AI in biology. It’s one of the most important frontiers for AI—but we can’t just copy what works for text or images. Biology speaks a different language.
Right now, two major directions are emerging... 1/8
Right now, two major directions are emerging... 1/8
November 15, 2025 at 5:58 AM
Saturday mornings are ideal for contemplating AI in biology. It’s one of the most important frontiers for AI—but we can’t just copy what works for text or images. Biology speaks a different language.
Right now, two major directions are emerging... 1/8
Right now, two major directions are emerging... 1/8
Reposted by SusanK
Reposted by SusanK
No salad today, only pumpkin
November 14, 2025 at 7:54 PM
No salad today, only pumpkin
Reposted by SusanK
The union is asking that you not patronize any Starbucks, even ones that aren't unionized, for the duration! Time to find your new favoriteocal coffee shop. To donate to their strike fund: sbworkersunited.org
November 13, 2025 at 8:16 PM
The union is asking that you not patronize any Starbucks, even ones that aren't unionized, for the duration! Time to find your new favoriteocal coffee shop. To donate to their strike fund: sbworkersunited.org