Tim Rhoads
@timwrhoads.bsky.social
Assistant Professor, Dept. of Nutritional Sciences, UW-Madison. Metabolism, RNA, and aging. All opinions my own (and not my employers).
Pinned
Tim Rhoads
@timwrhoads.bsky.social
· Nov 8
Trying to find all the metabolism/mito folks on here, so i created a starter pack. Please suggest anyone I missed!
go.bsky.app/C2t7snh
go.bsky.app/C2t7snh
Interestingly, my experience was the opposite. The orcid integration worked flawlessly, but i had nothing but problems trying to pull stuff in from my ncbi bibliography. It would never load more than about 1/3rd of my publications. Same conclusion though - lots of time on manual data entry.
PSA: submitting to the NIH Feb 5 deadline? You'll need a SciENcv biosketch. And the ORCID linkage is sketchy, not working at all for me, despite logout/login, unlink/relink/reauth ORCID. Be prepared to spend a LOT of time with manual data entry.
January 17, 2026 at 3:42 PM
Interestingly, my experience was the opposite. The orcid integration worked flawlessly, but i had nothing but problems trying to pull stuff in from my ncbi bibliography. It would never load more than about 1/3rd of my publications. Same conclusion though - lots of time on manual data entry.
Reposted by Tim Rhoads
Don’t let Russell Vought trick Congress into destroying science by removing multiyear funding limits from the NIH funding bill.
January 16, 2026 at 4:34 PM
Don’t let Russell Vought trick Congress into destroying science by removing multiyear funding limits from the NIH funding bill.
Reposted by Tim Rhoads
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
www.nature.com
January 16, 2026 at 7:46 AM
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tim Rhoads
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
January 16, 2026 at 4:27 PM
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
Reposted by Tim Rhoads
The Murphy Lab did our annual retreat this week. This year's theme was using AI (what it's good and bad for). I wanted to be open-minded to make sure we are not missing something we should be using it for, so we did a few exercises to test, and had presentations.
January 15, 2026 at 4:51 PM
The Murphy Lab did our annual retreat this week. This year's theme was using AI (what it's good and bad for). I wanted to be open-minded to make sure we are not missing something we should be using it for, so we did a few exercises to test, and had presentations.
Reposted by Tim Rhoads
“adoption of AI in science presents what seems to be a paradox: an expansion of individual scientists’ impact but a contraction in collective science’s reach, as AI-augmented work moves collectively towards areas richest in data...
One of my concerns with AI-assisted research in biology is that we're already looking only in the lamplight and AI incentivizes us to narrow the beam. Seems like it's happening...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Artificial intelligence tools expand scientists’ impact but contract science’s focus - Nature
Artificial intelligence boosts individual scientists’ output, citations and career progression, but collectively narrows research diversity and reduces collaboration, concentrating work in data-rich a...
www.nature.com
January 15, 2026 at 4:18 PM
“adoption of AI in science presents what seems to be a paradox: an expansion of individual scientists’ impact but a contraction in collective science’s reach, as AI-augmented work moves collectively towards areas richest in data...
Reposted by Tim Rhoads
The new NIH multi-year funding policy is a scheme to undercut the NIH budget and fund less science. And it’s working (see below). The Senate approps bill has language to limit MYF use, but the House version does not. Call your reps (House and Senate) and insist it’s included in the final bill! 🧪
Glad to see Congress doing some oversight of new NIH policies. www.congress.gov/crs-product/...
Number of new awards is way down since Trump took office, despite NIH spending the same amount of money.
Number of new awards is way down since Trump took office, despite NIH spending the same amount of money.
December 23, 2025 at 5:38 PM
The new NIH multi-year funding policy is a scheme to undercut the NIH budget and fund less science. And it’s working (see below). The Senate approps bill has language to limit MYF use, but the House version does not. Call your reps (House and Senate) and insist it’s included in the final bill! 🧪
Reposted by Tim Rhoads
A short Bluetorial about indirect cost rates and indirect cost recovery.
1/14
1/14
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
January 12, 2026 at 7:49 PM
A short Bluetorial about indirect cost rates and indirect cost recovery.
1/14
1/14
Reposted by Tim Rhoads
I took Tucker’s piece as an inspiration for my own post for the Civics of Technology and applying the Baldwin Test to investigate claims about educational technology:
Applying the Baldwin Test to Ed-Tech — Civics of Technology
In this post, Charles Logan argues that educators can apply the Baldwin Test to Ed-Tech.
www.civicsoftechnology.org
January 7, 2026 at 2:58 PM
I took Tucker’s piece as an inspiration for my own post for the Civics of Technology and applying the Baldwin Test to investigate claims about educational technology:
Reposted by Tim Rhoads
Scarce research funding is becoming more economically costly than the actual investment, especially when it’s a drop in the bucket for profoundly stupid fad topics like “GenAI to solve Africa’s problems.” This piece is SO important: www.nature.com/articles/d41...
Point of no returns: researchers are crossing a threshold in the fight for funding
With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.
www.nature.com
January 6, 2026 at 12:39 PM
Scarce research funding is becoming more economically costly than the actual investment, especially when it’s a drop in the bucket for profoundly stupid fad topics like “GenAI to solve Africa’s problems.” This piece is SO important: www.nature.com/articles/d41...
Reposted by Tim Rhoads
The final Calvin and Hobbes, which appeared in papers 30 years ago today.
December 31, 2025 at 5:00 PM
The final Calvin and Hobbes, which appeared in papers 30 years ago today.
Reposted by Tim Rhoads
Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria
This study introduces CRASP-seq, an RNA-coupled CRISPR screening platform designed to systematically identify regulatory factors and domains of alternative pre-mRNA splicing. Using this technology, ZNF207 is identified as a bona fide splicing regulator through its interaction with U1 snRNP components. ZNF207 modulates aberrant LMNA splicing, a critical event linked to progeria.
dlvr.it
December 30, 2025 at 4:19 PM
Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:
Reposted by Tim Rhoads
scoop: During a heated conference call this spring, the head of the Corporation for Public Broadcasting told Katherine Maher, the C.E.O. of NPR, that she should resign.
My profile of Katherine Maher, which goes behind-the-scenes of the most consequential fight in NPR’s history.
My profile of Katherine Maher, which goes behind-the-scenes of the most consequential fight in NPR’s history.
December 30, 2025 at 12:24 PM
scoop: During a heated conference call this spring, the head of the Corporation for Public Broadcasting told Katherine Maher, the C.E.O. of NPR, that she should resign.
My profile of Katherine Maher, which goes behind-the-scenes of the most consequential fight in NPR’s history.
My profile of Katherine Maher, which goes behind-the-scenes of the most consequential fight in NPR’s history.
Reposted by Tim Rhoads
it's completely bullshit that if I am paying open access fees, that the journals are not depositing the paper into NCBI.
December 29, 2025 at 6:17 PM
it's completely bullshit that if I am paying open access fees, that the journals are not depositing the paper into NCBI.
Reposted by Tim Rhoads
@acs.org has still not returned its inclusivity guides based on race/ethnicity or gender/sex/sexual-orientation/gender-identity. The idea that they "paused" them for "review and refinement" was a cover for caving to the Trump administration. @professor-dave.bsky.social
www.acs.org/about/inclus...
www.acs.org/about/inclus...
December 25, 2025 at 1:44 AM
@acs.org has still not returned its inclusivity guides based on race/ethnicity or gender/sex/sexual-orientation/gender-identity. The idea that they "paused" them for "review and refinement" was a cover for caving to the Trump administration. @professor-dave.bsky.social
www.acs.org/about/inclus...
www.acs.org/about/inclus...
Reposted by Tim Rhoads
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
December 21, 2025 at 3:58 AM
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
Reposted by Tim Rhoads
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Tim Rhoads
Christmas-physics cross-over joke
December 22, 2025 at 10:49 AM
Christmas-physics cross-over joke
Reposted by Tim Rhoads
I’m laid up with the flu, but I had to peek my head out and say that this is *so* much worse than it seems.
And it’s already pretty fucking bad!
bsky.app/profile/gbbr...
And it’s already pretty fucking bad!
bsky.app/profile/gbbr...
"Has feminism failed women brought to you by bank of america" is my MKULTRA sleeper agent activation phrase
December 20, 2025 at 10:56 PM
I’m laid up with the flu, but I had to peek my head out and say that this is *so* much worse than it seems.
And it’s already pretty fucking bad!
bsky.app/profile/gbbr...
And it’s already pretty fucking bad!
bsky.app/profile/gbbr...
Reposted by Tim Rhoads
Presenting, attending or excited to learn?
#ASBMB26 is all about scientific exchange, collaboration and inspiration.
Introduce yourself using this social media toolkit and meet fellow attendees before the conference kicks off — counting down to March!
www.asbmb.org/annual... #MakeItPossible
#ASBMB26 is all about scientific exchange, collaboration and inspiration.
Introduce yourself using this social media toolkit and meet fellow attendees before the conference kicks off — counting down to March!
www.asbmb.org/annual... #MakeItPossible
December 20, 2025 at 9:47 PM
Presenting, attending or excited to learn?
#ASBMB26 is all about scientific exchange, collaboration and inspiration.
Introduce yourself using this social media toolkit and meet fellow attendees before the conference kicks off — counting down to March!
www.asbmb.org/annual... #MakeItPossible
#ASBMB26 is all about scientific exchange, collaboration and inspiration.
Introduce yourself using this social media toolkit and meet fellow attendees before the conference kicks off — counting down to March!
www.asbmb.org/annual... #MakeItPossible
Reposted by Tim Rhoads
A Trump administration change to how the National Institutes of Health awards grants has sharply reduced early-stage investigators’ odds of securing funding, new data from the agency show. Teamed up with @aniloza.bsky.social for this @statnews.com story
www.statnews.com/2025/12/18/n...
www.statnews.com/2025/12/18/n...
NIH funding rates for early-career researchers plunged in 2025, new data show
A Trump administration change to how NIH awards grants has sharply reduced early-stage investigators’ odds of securing funding.
www.statnews.com
December 18, 2025 at 8:01 PM
A Trump administration change to how the National Institutes of Health awards grants has sharply reduced early-stage investigators’ odds of securing funding, new data from the agency show. Teamed up with @aniloza.bsky.social for this @statnews.com story
www.statnews.com/2025/12/18/n...
www.statnews.com/2025/12/18/n...
Reposted by Tim Rhoads
Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...
Chromatin buffers torsional stress during transcription
During eukaryotic transcription, Pol II must overcome nucleosome obstacles and, because of DNA’s helical structure, must also rotate relative to DNA, generating torsional stress. However, there is lim...
www.science.org
December 18, 2025 at 7:14 PM
Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...
Reposted by Tim Rhoads
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
December 16, 2025 at 11:41 PM
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
Reposted by Tim Rhoads
With a vibrant program featuring cutting-edge research and interdisciplinary collaboration, the 2026 ASBMB Annual Meeting offers unparalleled opportunities to deepen your expertise and broaden your impact.
☑️ Register early (by Feb. 3) and save: www.asbmb.org/annual-meeti.... #ASBMB26
☑️ Register early (by Feb. 3) and save: www.asbmb.org/annual-meeti.... #ASBMB26
December 17, 2025 at 9:55 PM
With a vibrant program featuring cutting-edge research and interdisciplinary collaboration, the 2026 ASBMB Annual Meeting offers unparalleled opportunities to deepen your expertise and broaden your impact.
☑️ Register early (by Feb. 3) and save: www.asbmb.org/annual-meeti.... #ASBMB26
☑️ Register early (by Feb. 3) and save: www.asbmb.org/annual-meeti.... #ASBMB26