@1rabp.bsky.social
Reposted
Before 2020 the idea that a virus could kill millions of people & bring western civilization to a standstill was unthinkable.
Now, the idea that we’re on the cusp of losing absolutely everything is also unthinkable.
But the science is clear - it’s all but inevitable.
Now, the idea that we’re on the cusp of losing absolutely everything is also unthinkable.
But the science is clear - it’s all but inevitable.
December 1, 2025 at 12:24 PM
Before 2020 the idea that a virus could kill millions of people & bring western civilization to a standstill was unthinkable.
Now, the idea that we’re on the cusp of losing absolutely everything is also unthinkable.
But the science is clear - it’s all but inevitable.
Now, the idea that we’re on the cusp of losing absolutely everything is also unthinkable.
But the science is clear - it’s all but inevitable.
Reposted
Even after the mansion tax is applied, the owner of a £5m home in Westminster will pay proportionately less in property tax than the owner of a £210k Band B property in Sunderland.
November 26, 2025 at 3:25 PM
Even after the mansion tax is applied, the owner of a £5m home in Westminster will pay proportionately less in property tax than the owner of a £210k Band B property in Sunderland.
Reposted
My dispatch from the northern Ukrainian city of Chernihiv. Russia has destroyed the region's energy infrastructure, bombing sub-stations, and leaving people without heat and in the dark. a sad story, with beautiful chiaroscuro pictures by @alessiomamo.bsky.social
www.theguardian.com/world/2025/n...
www.theguardian.com/world/2025/n...
‘They decided to kill us with cold’: Ukrainians struggle against Russian assault on power network
Chernihiv residents say they are without power for 14 hours a day as they gather in ‘invincibility points’ to charge up and warm up
www.theguardian.com
November 22, 2025 at 10:27 AM
My dispatch from the northern Ukrainian city of Chernihiv. Russia has destroyed the region's energy infrastructure, bombing sub-stations, and leaving people without heat and in the dark. a sad story, with beautiful chiaroscuro pictures by @alessiomamo.bsky.social
www.theguardian.com/world/2025/n...
www.theguardian.com/world/2025/n...
Reposted
We have VAT on energy bills and people this winter are choosing between heating and eating because it's such a difficult thing to afford, and a necessity. But if you fly on holiday, there's no VAT. So that's an example of how our tax system is regressive, those with the least contribute the most.
November 20, 2025 at 6:58 PM
We have VAT on energy bills and people this winter are choosing between heating and eating because it's such a difficult thing to afford, and a necessity. But if you fly on holiday, there's no VAT. So that's an example of how our tax system is regressive, those with the least contribute the most.
Tony Kouzarides is one of a kind. We each owe him so much. Thank you @davidlabmsk.bsky.social what an amazing event and picture.
Thank you so much to the always awesome and often times our epigenetics saviors, EpiCypher team, and especially Michael!!!
Thank you for joining and being so generous as usual with your insights, science and support of trainees!
Feels like we were all witnessing the end of an era 😢
Thank you for joining and being so generous as usual with your insights, science and support of trainees!
Feels like we were all witnessing the end of an era 😢
November 19, 2025 at 6:51 PM
Tony Kouzarides is one of a kind. We each owe him so much. Thank you @davidlabmsk.bsky.social what an amazing event and picture.
Reposted
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
www.nature.com
November 17, 2025 at 12:12 PM
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
𝐖𝐫𝐢𝐭𝐞 𝐭𝐨 𝐲𝐨𝐮𝐫 𝐌𝐏 𝐭𝐨 𝐝𝐞𝐦𝐚𝐧𝐝 𝐌𝐢𝐜𝐡𝐞𝐥𝐥𝐞 𝐌𝐨𝐧𝐞 𝐢𝐬 𝐬𝐭𝐫𝐢𝐩𝐩𝐞𝐝 𝐨𝐟 𝐡𝐞𝐫 𝐩𝐞𝐞𝐫𝐚𝐠𝐞 𝐚𝐧𝐝 𝐎𝐁𝐄!
The Government has the power to act. It's time Covid crooks were held accountable.
Click the link below to contact your MP ⬇️
actionnetwork.org/letters/mone...
The Government has the power to act. It's time Covid crooks were held accountable.
Click the link below to contact your MP ⬇️
actionnetwork.org/letters/mone...
Write to your MP to demand Michelle Mone is stripped of her peerage and OBE
Please write to your MP asking them to support our campaign to remove Michelle Mone from the House of Lords and strip her of her OBE. She should not keep honours and influence while £122 million of pu...
actionnetwork.org
October 30, 2025 at 2:39 PM
𝐖𝐫𝐢𝐭𝐞 𝐭𝐨 𝐲𝐨𝐮𝐫 𝐌𝐏 𝐭𝐨 𝐝𝐞𝐦𝐚𝐧𝐝 𝐌𝐢𝐜𝐡𝐞𝐥𝐥𝐞 𝐌𝐨𝐧𝐞 𝐢𝐬 𝐬𝐭𝐫𝐢𝐩𝐩𝐞𝐝 𝐨𝐟 𝐡𝐞𝐫 𝐩𝐞𝐞𝐫𝐚𝐠𝐞 𝐚𝐧𝐝 𝐎𝐁𝐄!
The Government has the power to act. It's time Covid crooks were held accountable.
Click the link below to contact your MP ⬇️
actionnetwork.org/letters/mone...
The Government has the power to act. It's time Covid crooks were held accountable.
Click the link below to contact your MP ⬇️
actionnetwork.org/letters/mone...
Reposted
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
The value of public R&D
www.gov.uk
October 30, 2025 at 1:28 PM
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
www.gov.uk/government/p...
Reposted
The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested!
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
Principal Scientist, Center for Advanced Molecular and Immunological Therapies
Develop a research program in the advancement of immunological therapies.Play a crucial role in all aspects of research development, implementation, a...
arizona.csod.com
October 30, 2025 at 12:53 AM
The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested!
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
Reposted
Peter #Thiel is more dangerous smarter version of Elon #Musk
We should not allow him to influence UK politics any more than we can.
Thanks to @bylinetimes.bsky.social @bylinesnetwork.co.uk
We should not allow him to influence UK politics any more than we can.
Thanks to @bylinetimes.bsky.social @bylinesnetwork.co.uk
The Thiel Effect.
YouTube video by Byline TV
youtu.be
October 25, 2025 at 12:50 PM
Peter #Thiel is more dangerous smarter version of Elon #Musk
We should not allow him to influence UK politics any more than we can.
Thanks to @bylinetimes.bsky.social @bylinesnetwork.co.uk
We should not allow him to influence UK politics any more than we can.
Thanks to @bylinetimes.bsky.social @bylinesnetwork.co.uk
Reposted
The Demise Of Planet X lands 16 Jan 💣 Loads of tasty formats to stick in your ears.
Pre-order here: sleafordmods.ffm.to/demise
We’re giving you:
🟢 One pressing Glow in the Dark Vinyl
🟢 Neon Green Marble Vinyl
📸 Nottz edition Picture Disc
🟩 Ltd Toxic Green Cassette
⚫️ Standard Black Vinyl
💿 CD
Pre-order here: sleafordmods.ffm.to/demise
We’re giving you:
🟢 One pressing Glow in the Dark Vinyl
🟢 Neon Green Marble Vinyl
📸 Nottz edition Picture Disc
🟩 Ltd Toxic Green Cassette
⚫️ Standard Black Vinyl
💿 CD
October 24, 2025 at 9:51 AM
The Demise Of Planet X lands 16 Jan 💣 Loads of tasty formats to stick in your ears.
Pre-order here: sleafordmods.ffm.to/demise
We’re giving you:
🟢 One pressing Glow in the Dark Vinyl
🟢 Neon Green Marble Vinyl
📸 Nottz edition Picture Disc
🟩 Ltd Toxic Green Cassette
⚫️ Standard Black Vinyl
💿 CD
Pre-order here: sleafordmods.ffm.to/demise
We’re giving you:
🟢 One pressing Glow in the Dark Vinyl
🟢 Neon Green Marble Vinyl
📸 Nottz edition Picture Disc
🟩 Ltd Toxic Green Cassette
⚫️ Standard Black Vinyl
💿 CD
Reposted
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
www.biorxiv.org
October 23, 2025 at 12:50 PM
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Reposted
PREORDER: 'Alias (5th Anniversary Edition)' by Shygirl
Shygirl marks five years of her breakout release hearing left-field pop, hip-hop, hyperpop, and UK club production collide.
We've got a limited number of signed copies to go around.
www.normanrecords.com/records/2122...
Shygirl marks five years of her breakout release hearing left-field pop, hip-hop, hyperpop, and UK club production collide.
We've got a limited number of signed copies to go around.
www.normanrecords.com/records/2122...
Shygirl - Alias (5th Anniversary Edition)
Buy ALIAS (5TH ANNIVERSARY EDITION) by SHYGIRL. LP £21.49. Order online today and get FREE UK delivery on orders over £75.
www.normanrecords.com
October 10, 2025 at 9:01 AM
PREORDER: 'Alias (5th Anniversary Edition)' by Shygirl
Shygirl marks five years of her breakout release hearing left-field pop, hip-hop, hyperpop, and UK club production collide.
We've got a limited number of signed copies to go around.
www.normanrecords.com/records/2122...
Shygirl marks five years of her breakout release hearing left-field pop, hip-hop, hyperpop, and UK club production collide.
We've got a limited number of signed copies to go around.
www.normanrecords.com/records/2122...
Reposted
Baroness Mone's company got £122 million for faulty PPE while NHS staff risked their lives.
More than 80,000 have signed our petition to remove her from the Lords.
Add your name 👇
www.change.org/MichelleMone
More than 80,000 have signed our petition to remove her from the Lords.
Add your name 👇
www.change.org/MichelleMone
Sign the Petition
Strip Michelle Mone of her peerage
www.change.org
October 10, 2025 at 9:17 AM
Baroness Mone's company got £122 million for faulty PPE while NHS staff risked their lives.
More than 80,000 have signed our petition to remove her from the Lords.
Add your name 👇
www.change.org/MichelleMone
More than 80,000 have signed our petition to remove her from the Lords.
Add your name 👇
www.change.org/MichelleMone
Reposted
Byline Times once more doing essential investigative journalism while the mainstream media try to sweep it all under the carpet.
Please read because every time the BBC, Daily Mail etc. give Farage/Reform airtime or column inches, this is what they're really platforming.
Please read because every time the BBC, Daily Mail etc. give Farage/Reform airtime or column inches, this is what they're really platforming.
🔴NEW🔴
Thread 🧵
@bylinetimes.bsky.social can now reveal that, during the crucial period when convicted Reform leader Nathan Gill was most active, working directly with Russian President Vladimir Putin’s most senior ally in Ukraine, he was also one of Nigel Farage’s closest confidantes 1/12
Thread 🧵
@bylinetimes.bsky.social can now reveal that, during the crucial period when convicted Reform leader Nathan Gill was most active, working directly with Russian President Vladimir Putin’s most senior ally in Ukraine, he was also one of Nigel Farage’s closest confidantes 1/12
‘Thick as Thieves’: Nathan Gill and Nigel Farage’s Putin Problem
Far from being distant from the Reform UK Leader, insiders told Byline Times that the former MEP convicted of bribery was one of Farage’s closest aides, while we reveal how Gill worked on the Kremlin’...
bylinetimes.com
October 4, 2025 at 2:55 PM
Byline Times once more doing essential investigative journalism while the mainstream media try to sweep it all under the carpet.
Please read because every time the BBC, Daily Mail etc. give Farage/Reform airtime or column inches, this is what they're really platforming.
Please read because every time the BBC, Daily Mail etc. give Farage/Reform airtime or column inches, this is what they're really platforming.
Reposted
With Kemi Badenoch saying the Tories would take the UK out of the ECHR, this YouGov poll in June found the public wanted to remain members by 51% to 27%
October 4, 2025 at 5:30 PM
With Kemi Badenoch saying the Tories would take the UK out of the ECHR, this YouGov poll in June found the public wanted to remain members by 51% to 27%
Reposted
“Our investigation uncovered that an elected MEP was taking payments to peddle narratives beneficial to Russian interests... This case goes to the heart of our democratic values.”
— head of the Met’s Counter Terrorism Command, Commander Dominic Murphy
— head of the Met’s Counter Terrorism Command, Commander Dominic Murphy
🚨 This is serious. Ex Reform UK leader in Wales, Nathan Gill, 52, pleads guilty to accepting bribes in exchange for making pro-Russia statements in the European Parliament when serving as a UKIP MEP.
Ex-Reform leader pleads guilty to Pro-Russia bribery charges
The former leader of Reform UK in Wales has pleaded guilty to numerous bribery charges relating to pro-Russian statements.
caerphilly.observer
September 27, 2025 at 9:58 AM
“Our investigation uncovered that an elected MEP was taking payments to peddle narratives beneficial to Russian interests... This case goes to the heart of our democratic values.”
— head of the Met’s Counter Terrorism Command, Commander Dominic Murphy
— head of the Met’s Counter Terrorism Command, Commander Dominic Murphy
Reposted
The Five Questions Nigel Farage is Never Asked About Brexit, Trump and Russia – Byline Times bylinetimes.com/2024/06/19/t...
The Five Questions Nigel Farage is Never Asked About Brexit, Trump and Russia
As the media provides the Reform Leader with a prominent platform, Peter Jukes considers all the concerning lines of enquiry that journalists never confront him with
bylinetimes.com
August 6, 2025 at 8:04 PM
The Five Questions Nigel Farage is Never Asked About Brexit, Trump and Russia – Byline Times bylinetimes.com/2024/06/19/t...
Reposted
"As Climate Disasters Worsen, Trump Admin Guts Environmental Rules" | A conversation between @democracynow.org's AmyGoodman, @nrdc.org's @daviddoniger.bsky.social & yours truly. Please watch!
www.youtube.com/watch?v=O8fz...
www.youtube.com/watch?v=O8fz...
Trump's EPA Is Gutting "The Main Tool We Have to Reduce Carbon Emissions"
YouTube video by Democracy Now!
www.youtube.com
August 1, 2025 at 6:37 PM
"As Climate Disasters Worsen, Trump Admin Guts Environmental Rules" | A conversation between @democracynow.org's AmyGoodman, @nrdc.org's @daviddoniger.bsky.social & yours truly. Please watch!
www.youtube.com/watch?v=O8fz...
www.youtube.com/watch?v=O8fz...
Reposted
Some very exciting news to share!!
Huge news! A £50M MRC CoRE will bring together Manchester & Oxford to study how environmental exposures cause chronic inflammatory disease.
The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.
www.kennedy.ox.ac.uk/news/new-ps5...
The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.
www.kennedy.ox.ac.uk/news/new-ps5...
New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases
A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, ...
www.kennedy.ox.ac.uk
July 20, 2025 at 9:50 PM
Some very exciting news to share!!
Reposted
"National TV news largely failed to connect the record-breaking eastern U.S. heat dome to climate change" via @mmfa.bsky.social: www.mediamatters.org/broadcast-ne...
National TV news largely failed to connect the record-breaking Eastern U.S. heat dome to climate change
A record-breaking heat dome scorched the United States in late June, setting or tying high-temperature records in more than 280 locations and placing more than 130 million people under extreme heat ad...
www.mediamatters.org
July 2, 2025 at 2:07 PM
"National TV news largely failed to connect the record-breaking eastern U.S. heat dome to climate change" via @mmfa.bsky.social: www.mediamatters.org/broadcast-ne...
Congratulations to the Novartis team Fiona
Excited to see this work in @natchembio.nature.com from our Novartis teams. They report the discovery of a small molecule that binds pVHL, functioning as a molecular glue degrader. The findings suggest new opportunities to leverage VHL molecular glues.
www.nature.com/articles/s41...
#SciSky
www.nature.com/articles/s41...
#SciSky
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 - Nature Chemical Biology
High-content protein arrays were used to identify cysteine dioxygenase (CDO1) as a small-molecule glue target for the von Hippel–Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal ...
www.nature.com
June 25, 2025 at 10:31 PM
Congratulations to the Novartis team Fiona
Congratulations Vijay and all on this excellent work.
[email protected], @romberglab.bsky.social and @bloodgenes.bsky.social review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...
June 25, 2025 at 10:03 PM
Congratulations Vijay and all on this excellent work.
Reposted
Do I have any BlueSky folks who might help advise me on how to generate a graph genome from dbSNP or 1000 Genomes data? Or advice on how to do variant-aware TF motif calling?
June 25, 2025 at 9:17 PM
Do I have any BlueSky folks who might help advise me on how to generate a graph genome from dbSNP or 1000 Genomes data? Or advice on how to do variant-aware TF motif calling?
Reposted
Worse still, Drax claims the trees arrive in Britain entirely carbon free, and burning them makes ‘green’ - who are they kidding? Perhaps the biggest greenwash Britain has ever suffered. Time to end it.
June 22, 2025 at 12:07 PM
Worse still, Drax claims the trees arrive in Britain entirely carbon free, and burning them makes ‘green’ - who are they kidding? Perhaps the biggest greenwash Britain has ever suffered. Time to end it.