Objective: As many as half of individuals who develop psychosis had attended child and adolescent psychiatric services at some stage in childhood, highlighting substantial opportunities for prevention...

In people with HIV-1 and with neurocognitive impairment, the A5324 trial tested the effect of antiretroviral therapy (ART) intensification with either dolu

Obesity can cause physiological changes resulting in antibiotic pharmacokinetic alterations and suboptimal drug exposures. This systematic review aimed to summarise the available evidence on this topi...

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

Reviewer(s): H Izumiya (National Institute of Infectious Diseases, Tokyo) | 📗📗📗📗◻️ • J Gunn & P Muturi (The Ohio State University) | 📗📗📗📗◻️ • P T Duy (Oxford University Clinical Research Unit) | 📘...

This trial was inconclusive regarding the impact of ceftriaxone prophylaxis to reduce the incidence of EOP after OHCA but ceftriaxone was associated with less frequent administration of open-label ant...

AbstractObjectivesThe purpose of this study was to analyse nationwide trends in antimicrobial susceptibility and molecular epidemiology of all MRSA strains in Norway over a 10-year period.Materials and methodsAll cases of MRSA in Norway from 2008 to 2017 were included, limited to the first case per year per individual (n = 15 200). Strains were confirmed as MRSA with PCR and genotyped using spa-typing. Antimicrobial susceptibility data and epidemiological data were collected from the Norwegian MRSA reference laboratory and the Norwegian Surveillance System for Communicable Diseases, respectively.ResultsDespite an increase in MRSA cases, antimicrobial resistance rates remained stable throughout the study period. The most common susceptibility profile of the MRSA strains was resistance to cefoxitin alone (41.4%), while co-resistance (58.6%) was observed most commonly for erythromycin (31.0%), tetracycline (25.3%) and ciprofloxacin/norfloxacin (21.6%). Notably, associations were identified between specific resistance patterns and clinical variables, including higher resistance rates among healthcare-associated MRSA, particularly in older adults and nursing home residents. Geographic associations were also observed, linking specific resistance profiles to strains acquired in North America, Africa and Asia.ConclusionsThe findings highlight a complex landscape of MRSA resistance in a low-prevalence country, characterized by a diverse genotypic population and stable longitudinal trends in resistance rates. However, the prevalence of co-resistance to one or more antibiotics among Norwegian MRSA strains was high and increasing. This study thus underscores the importance of continuous surveillance and adherence to antimicrobial guidelines.

One in six laboratory-confirmed bacterial infections causing common infections in people worldwide in 2023 were resistant to antibiotic treatments, according to a new World Health Organization (WHO) r...

Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.

In no particular order, 20 things I’ve found interesting lately — a mix of ID (mostly), language quirks, clinical stuff, even tennis, and an apology (#21) at the very end. Bonus videos embedded becaus...

Daptomycin has been used with success for the treatment of right-sided methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. However, its efficacy has not been completely assessed for the t...

Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy - Volume 5 Issue 1