Adrian
@aconga.bsky.social
PostDoc at EEP-Lille. Interested in the repetitive, but complex, fraction that make up most of the genomes. Fan del Sol
Reposted by Adrian
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Adrian
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by Adrian
#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH
November 21, 2025 at 12:07 AM
#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH
Reposted by Adrian
Out First Release in @science.org this week:
A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
www.science.org
September 22, 2025 at 4:09 PM
Out First Release in @science.org this week:
A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability
www.science.org/doi/10.1126/...
#PlantScience
Reposted by Adrian
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Reposted by Adrian
🌻 Sharing this preprint where we assembled 3 new chromosome-level genomes, including the first for Asteraceae's South American sister Calyceraceae! Asteraceae uses all the tricks when it comes to being the most ecologically successful family of flowering plants. www.biorxiv.org/content/10.1...
www.biorxiv.org
November 14, 2025 at 5:00 PM
🌻 Sharing this preprint where we assembled 3 new chromosome-level genomes, including the first for Asteraceae's South American sister Calyceraceae! Asteraceae uses all the tricks when it comes to being the most ecologically successful family of flowering plants. www.biorxiv.org/content/10.1...
Reposted by Adrian
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein
Non-LTR retrotransposon proteins copy their RNA template into a genome via coordinated nicking and reverse transcriptase activities of target-primed reverse transcription. Mechanisms by which the firs...
www.science.org
November 13, 2025 at 8:05 PM
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Reposted by Adrian
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
www.biorxiv.org
June 20, 2025 at 7:39 PM
The first paper of my PhD is now available as a preprint! 🎉
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.
Reposted by Adrian
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
November 12, 2025 at 1:17 PM
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Reposted by Adrian
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
Reposted by Adrian
If you're in Ghent tomorrow ! I'll be sharing our recent progress deciphering the sRNA-based dominance/recessivity interactions at the self-incompatibility locus in Arabidopsis 🌱
TOMORROW: SEMINAR by @vincentcastric.bsky.social from @univlille.bsky.social @cnrs.fr, invited by @pnovik.bsky.social and @yvdp.bsky.social. @viblifesciences.bsky.social
November 12, 2025 at 10:12 AM
If you're in Ghent tomorrow ! I'll be sharing our recent progress deciphering the sRNA-based dominance/recessivity interactions at the self-incompatibility locus in Arabidopsis 🌱
Reposted by Adrian
🚀 philentropy v0.10.0 is on CRAN!
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
November 4, 2025 at 9:31 AM
🚀 philentropy v0.10.0 is on CRAN!
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Now with long-awaited parallel distance computation & a full speed-optimized refactor thanks to Andrew Gene Brown.
Compute 50+ distances/divergences in R faster than ever.
📦 CRAN: cran.r-project.org/web/packages...
💻 Code: github.com/drostlab/phi...
Reposted by Adrian
Interested in doing a PhD? The TREES doctoral training program is now open for applications!
🌱 PhD Applications Open – TREES Doctoral Training Programme
TREES (Doctoral Landscape Alliance) is now accepting applications for fully funded PhD studentships in UKRI-NERC science remit.
🔗 trees-dla.ac.uk
#PhDOpportunity #AcademicTwitter #Ecology #ClimateResearch #PhDApplications
TREES (Doctoral Landscape Alliance) is now accepting applications for fully funded PhD studentships in UKRI-NERC science remit.
🔗 trees-dla.ac.uk
#PhDOpportunity #AcademicTwitter #Ecology #ClimateResearch #PhDApplications
Home | TREES DLA
TREES is a dynamic new programme for doctoral training designed to equip the next generation of environmental scientists to tackle today's critical global challenges. Sign up to the TREES mailing…
trees-dla.ac.uk
October 29, 2025 at 8:26 AM
Interested in doing a PhD? The TREES doctoral training program is now open for applications!
Reposted by Adrian
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
November 6, 2025 at 1:29 PM
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
Reposted by Adrian
Only a few days left to register and join us in Lille for this first ever French edition of PopGroup!
Hi Folks !
Just a few more days to register for the POPGROUP meeting (deadline = this Monday 10/11/2025).
Join us in the beautiful city of #Lille just across the Channel for three exciting days of science and more !
www.hautsdefrancetourism.com/destinations...
--> populationgeneticsgroup.org.uk
Just a few more days to register for the POPGROUP meeting (deadline = this Monday 10/11/2025).
Join us in the beautiful city of #Lille just across the Channel for three exciting days of science and more !
www.hautsdefrancetourism.com/destinations...
--> populationgeneticsgroup.org.uk
November 5, 2025 at 9:49 AM
Only a few days left to register and join us in Lille for this first ever French edition of PopGroup!
Hermaphroditic plants also use TIME ⏰🌿 to avoid selfing.
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
November 4, 2025 at 7:30 PM
Hermaphroditic plants also use TIME ⏰🌿 to avoid selfing.
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Two new @currentbiology.bsky.social papers explore the rapid turnover of this trait in the wingnut family.
Both @vincentcastric.bsky.social and I summarized these findings 👉 authors.elsevier.com/a/1m2MA3QW8S...
#Evolution #PlantBiology
Reposted by Adrian
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
October 24, 2025 at 1:51 AM
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Reposted by Adrian
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Mechanisms of Messenger RNA Packaging and Export
The packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs ar...
www.annualreviews.org
October 18, 2025 at 3:08 PM
what you always wanted to know about the molecular choreography of nuclear mRNA packaging and export.
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
thought-provoking review by our colleagues (local or in the RNA community).
@plaschkalab.bsky.social
@rupertfaraway.bsky.social
@thezenklusen.bsky.social
www.annualreviews.org/content/jour...
Reposted by Adrian
Amazing!!
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 6:41 PM
Amazing!!
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Congrats to the team for uncovering this link
We are all phages …
Regular reminder to the “The frustrated gene” article from @hitenmadhani.bsky.social
Reposted by Adrian
It may look like CGI, but this is the real deal: It's an accurate 3D rendering of our galactic neighborhood, highlighting the locations where new stars are being born.
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
October 16, 2025 at 5:16 PM
It may look like CGI, but this is the real deal: It's an accurate 3D rendering of our galactic neighborhood, highlighting the locations where new stars are being born.
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
This animation is based on measurements of 44 million stars by the Gaia space telescope. 🧪🔭
www.esa.int/Science_Expl...
Reposted by Adrian
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use diff…
www.sciencedirect.com
October 1, 2025 at 12:06 AM
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Reposted by Adrian
I heard James talking to @mrjamesob.bsky.social earlier & on the back of that, I’ve decided to subscribe to @thenewworldmag.bsky.social
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
You might think controlling GB News gives you huge influence over UK politics – especially on the right. But that's just the tip of the iceberg, as we reveal in this week's issue of @thenewworldmag.bsky.social
Full story: www.thenewworld.co.uk/james-ball-p...
Full story: www.thenewworld.co.uk/james-ball-p...
October 16, 2025 at 4:53 PM
I heard James talking to @mrjamesob.bsky.social earlier & on the back of that, I’ve decided to subscribe to @thenewworldmag.bsky.social
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
They’re doing 10 weeks for £10! A bargain for such brilliant journalism. Sign up if you can 👏
Reposted by Adrian
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In most species within the walnut family, two genetically determined morphs alternate
between male and female flowering phases in time. Groh et al. identify a distinct
locus for this dimorphism in two...
www.cell.com
October 16, 2025 at 3:43 PM
Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...
Reposted by Adrian
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 10, 2025 at 12:57 PM
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
Reposted by Adrian
Have you ever wondered why pumpkins are never purple or blue like other plants? 🎃🌈
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
October 10, 2025 at 11:35 AM
Have you ever wondered why pumpkins are never purple or blue like other plants? 🎃🌈
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...
While most plants can produce pink, blue, and purple pigments (thanks to anthocyanins), the Cucurbitaceae family 🍈 🍉 🥒have lost all the pathway genes to produce these pigments.
🔗 doi.org/10.1101/2025...