Adam Blanchard
@addyblanch.bsky.social
180 followers 240 following 27 posts
Associate Professor in Computational Biology | University of Nottingham | School of Veterinary Medicine and Science | Deputy Head of Division Microbial genomics | Antimicrobial Resistance | Metagenomics | Production Animal Health and Disease
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Reposted by Adam Blanchard
jsantoyo.bsky.social
MAGdb: a comprehensive high quality MAGs repository for exploring microbial metagenome-assemble genomes. #MAGs #Metagenomics #MetagenomeAssembly #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
Reposted by Adam Blanchard
acritschristoph.bsky.social
Cool result: Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii

"Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio
All organisms have the capacity for evolution through mutation. Bacteria with high mutation rates have a survival advantage in some stressful environments because they generate beneficial mutations mo...
journals.asm.org
Reposted by Adam Blanchard
rafalmostowy.bsky.social
What determines who a phage can infect?

We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.

👇 A thread!
Reposted by Adam Blanchard
katholt.bsky.social
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules
addyblanch.bsky.social
It’s seems worse now than I remember previously. Had one sent back with an email saying it didn’t have a data statement when it did, then had to waste more time resubmitting it.
Reposted by Adam Blanchard
titus.idyll.org
Super cool #bioinformatics tool alert: @widdowquinn.bsky.social group releases PyANI-plus, a flexible tool for exploring whole-genome similarity on large AND detailed scales. Walkthrough available below!
pyANI-plus walkthrough – pyANI-plus
pyani-plus.github.io
Reposted by Adam Blanchard
addyblanch.bsky.social
We investigated those too. Was told they couldn’t guarantee they would work with cocci.
Reposted by Adam Blanchard
nizet.bsky.social
New work showing that multidrug-resistant 𝘈𝘤𝘪𝘯𝘦𝘵𝘰𝘣𝘢𝘤𝘵𝘦𝘳 𝘣𝘢𝘶𝘮𝘢𝘯𝘯𝘪𝘪 isn’t a scattered threat—it’s a structured epidemic!

A dominant super-lineage and a rising clade (2.5.6) are spreading worldwide, fueled by gene exchange.

Li et al. Nat Commun
#AMR #bacterialgenomics

www.nature.com/articles/s41...
Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii - Nature Communications
In this study, authors conduct a genomic analysis of 15,000 Acinetobacter baumannii isolates, revealing a dominant multidrug-resistant super-lineage (accounting for approximately 70% global isolates),...
www.nature.com
Reposted by Adam Blanchard
noemielefrancq.bsky.social
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx

We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.

🧵 A thread... 1/n
#IDSky #IDModelling
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
buff.ly
Reposted by Adam Blanchard
craigmaclean.bsky.social
This is very important -
shortening antibiotic treatment duration is a good way to reduce consumption
jonathanrydermd.bsky.social
Systematic review of antibiotic durations in @jac-amr.bsky.social

n=315 RCTs

85% demonstrated equivalence or non-inferiority of shorter therapy

Only 7% in ICU, 14% in LMIC, and 15% low risk of bias

academic.oup.com/jacamr/artic...
Reposted by Adam Blanchard
jcamthrash.bsky.social
PredCMB: Predicting changes in microbial metabolites based on the gene-metabolite network analysis of shotgun metagenome data academic.oup.com/bioinformati... #jcampubs
Reposted by Adam Blanchard
evelienadri.bsky.social
I thoroughly enjoyed this read. It put into words my own thought well. Definitely going to take up some of the suggestions.
labliston.bsky.social
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org