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Reposted by Alexander Hanzl

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 14d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Reposted by Alexander Hanzl

FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

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Alexandra Bendel @alexbendel.bsky.social · Aug 25

I am happy to finally share this preprint of my PhD project in @guillaumediss.bsky.social lab at the FMI in Basel.
We used ddPCA to map the genetic architecture of the entire human bZIP interaction network.

www.biorxiv.org/content/10.1...

Thanks to all our co-authors for the great collaboration!

The genetic architecture of the human bZIP family

Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...

www.biorxiv.org

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Reposted by Alexander Hanzl

Kai Johnsson @kjohnsson.bsky.social · Jul 3

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

www.nature.com

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Jakob Schnabl @jakobschnabl.bsky.social · Jul 3

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment

Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...

www.biorxiv.org

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Marc Bühler @marcbuhler.bsky.social · Jul 3

Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues

Jakob Schnabl @jakobschnabl.bsky.social · Jul 3

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment

Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...

www.biorxiv.org

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Reposted by Alexander Hanzl

Thomä lab @labthoma.bsky.social · May 8

📝 🚨 Review alert from the Thomä Lab

@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky

Primed for degradation: How weak protein interactions enable molecular glue degraders

Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…

tinyurl.com

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Alexander Hanzl @alexanderhanzl.bsky.social · May 8

Huge hanks to @labthoma.bsky.social, @fmiscience.bsky.social and @snsf-ch.bsky.social for all the support

tinyurl.com/mpmbuuky

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Alexander Hanzl @alexanderhanzl.bsky.social · May 8

- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.

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Alexander Hanzl @alexanderhanzl.bsky.social · May 8

We highlight among others:
- Computational predictions of neosubstrates by @monterosatx.com
- Engineering target specificity by @ericfischer.bsky.social, colleagues @novartis.bsky.social as well as David Liu

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Alexander Hanzl @alexanderhanzl.bsky.social · May 8

📝 Review alert 🚨 from @labthoma.bsky.social
Stefan, Clara, Nico and I have collected our thoughts on recent discoveries of molecular glue degraders for a special issue of CurrOpinStrucBiol edited by Philip Biggin and Roderick Hubbard. 👇

tinyurl.com/mpmbuuky

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Ben Lehner @benlehner.bsky.social · May 6

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social

Building AI models or the data to train them?

Core funding of >$130M a year for a faculty of ~30.

www.nature.com/naturecareer...

acrobat.adobe.com/id/urn:aaid:...

pls RT!

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RCSB Protein Data Bank @rcsbpdb.bsky.social · May 4

Changes in PDB IDs are coming that will require use of PDBx/mmCIF file format... will you be ready? #MayThe4th
Resources are available to help: www.wwpdb.org/docume...

Him: Structures in PDB format
Her: Do you mean mmCIF and not deprecated format, right?
Him:
Her: RIGHT?

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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Mar 29

Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth

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Georg Winter @georgwinter.bsky.social · Mar 13

Something that qualifies as big news from my side:
I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence.

Find out more in the link and 🧵 below

lnkd.in/d_HaGuSE

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Marc Bühler @marcbuhler.bsky.social · Feb 27

The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team!
www.sciencedirect.com/science/arti...

A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin

Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyce…

www.sciencedirect.com

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Nik Fortelny @nikfortelny.bsky.social · Feb 21

We are hiring two tenured full-time professors in Salzburg, Austria!

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Brian Liau @brianliau.bsky.social · Feb 12

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

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Jakob Farnung @jakobfarnung.bsky.social · Jan 29

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

www.nature.com

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FMI science @fmiscience.bsky.social · Dec 16

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

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Michael Stadler @mbstadler.bsky.social · Jan 15

Permanent position for a Linux Systems Engineer: Are you fond of scientific computing and/Linux/HPC and would enjoy working in a vibrant research environment? Have a look at our job opening: www.fmi.ch/education-ca...

Friedrich Miescher Institute, open position

www.fmi.ch

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