Bacteria and archaea possess an enormous variety of antivirus immune systems that often share homologous proteins and domains, some of which contribute to diverse defense strategies. YprA family helic...

Anti-bacteriophage systems like restriction-modification and CRISPR-Cas have DNA substrate specificity mechanisms that enable identification of invaders. How Gabija, a highly prevalent nuclease-helica...

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid with a broad ho...

Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th

It's hoped phages could give us new ways of treating infections which are immune to antibiotics.

CRISPR-Cas systems endow bacteria and archaea with adaptive immunity against mobile genetic elements, playing a fundamental role in shaping microbial communities. Many organisms harbor more than one C...

Mahler et al. describe a phage DNA modification that adds arabinose to cytosines via a hydroxy linkage. This 5ara-hC modification can be further modified to double and triple arabinosylation by phage-...

Bacteria contain an array of immune systems, with many yet to be discovered. Brenes and Laub isolate temperate phages from diverse E. coli strains, enabling identification of 17 conserved, prophage-en...

AbstractAims. In phage therapy case studies, 1–3 bacteria isolates are typically tested against phages (phagogram). However, as bacteria populations differ

Phollow is an in vivo tagging approach for marking bacteriophages with fluorescent proteins while new virions are assembled in bacteria, enabling direct observation of phage outbreaks with single-virion resolution. Using Phollow to track phages in situ in model gut microbial communities uncovers spatiotemporal features of transmission dynamics that shape microbiomes.