anoopsinghchauhan.bsky.social
Anoop Chauhan
@anoopsinghchauhan.bsky.social
50 followers 120 following 2 posts
Cancer Biologist. Unraveling the secrets of genomic stability and its disruption.
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anoopsinghchauhan.bsky.social
Anoop Chauhan @anoopsinghchauhan.bsky.social · Apr 14
📢 Just published! Excited to share my latest research, now published in Nature Communications! Grateful to my collaborators and mentors who made this work possible.
@profstewartlab.bsky.social @Jo Morris, @Aneika C. Leney, @drjhujh.bsky.social

www.nature.com/articles/s41...
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance - Nature Communications
The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step post-translational cascade regulating RNF...
www.nature.com
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Reposted by Anoop Chauhan
chowdhurylab.bsky.social
Chowdhury Lab @chowdhurylab.bsky.social · May 22
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
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Reposted by Anoop Chauhan
profstewartlab.bsky.social
Grant Stewart @profstewartlab.bsky.social · May 14
Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and @anoopsinghchauhan.bsky.social. www.nature.com/articles/s41...
Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin - Nature Communications
DNA double strand break repair pathways ensure genome stability and prevent disease. Here the authors show that the actin nucleating factor DIAPH1 and γ-actin promote homologous recombination (HR)-dep...
www.nature.com
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Reposted by Anoop Chauhan
spjacksongroup.bsky.social
spjacksongroup.bsky.social @spjacksongroup.bsky.social · Apr 14
Thrilled to see this “veritable tour de force” led by John_C_Fielden from Jacob Corn lab out @nature.com, rdcu.be/ehd4E. This @erc.europa.eu funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!
Comprehensive interrogation of synthetic lethality in the DNA damage response
Nature - Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in...
rdcu.be
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anoopsinghchauhan.bsky.social
Anoop Chauhan @anoopsinghchauhan.bsky.social · Apr 14
📢 Just published! Excited to share my latest research, now published in Nature Communications! Grateful to my collaborators and mentors who made this work possible.
@profstewartlab.bsky.social @Jo Morris, @Aneika C. Leney, @drjhujh.bsky.social

www.nature.com/articles/s41...
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance - Nature Communications
The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step post-translational cascade regulating RNF...
www.nature.com
3 4
Reposted by Anoop Chauhan
sjorsscheres.bsky.social
Sjors Scheres @sjorsscheres.bsky.social · Feb 19
We are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat!

www.jobs.ac.uk/job/DLY086/s...
Senior Administrator (Divisional Administrator) - Structural Studies - LMB 2565 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
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Reposted by Anoop Chauhan
labvincenzo.bsky.social
Vincenzo Costanzo @labvincenzo.bsky.social · Jan 17
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.

www.keystonesymposia.org/conferences/...
DNA Replication Gaps, Cancer and Disease | Keystone Symposia
Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!
www.keystonesymposia.org
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Reposted by Anoop Chauhan
tat1anamoiseeva.bsky.social
Tatiana Moiseeva @tat1anamoiseeva.bsky.social · Jan 10
Fascinating paper! No G2/M checkpoint for under-replicated cells!
academic.oup.com/nar/article/...
Cell cycle progression of under-replicated cells
Abstract. Cell cycle checkpoints are the regulatory mechanisms that secure the strict order of cellular events for cell division that ensure genome integri
academic.oup.com
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Reposted by Anoop Chauhan
genomestability.bsky.social
Andrew Deans @genomestability.bsky.social · Dec 4
Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.
drewberry.bsky.social
Drew Berry wehi.tv @drewberry.bsky.social · Dec 4
Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
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Reposted by Anoop Chauhan
genomestability.bsky.social
Andrew Deans @genomestability.bsky.social · Dec 3
DNA nicks in either the leading or lagging strand templates can trigger break-induced replication (although nicks are introduced with Cas9n, Flp or gp2 that also create an R-loop or covalent protein barrier). In yeast. www.cell.com/molecular-ce...
DNA nicks in both leading and lagging strand templates can trigger break-induced replication
Xu et al. demonstrate that single-stranded breaks in either the leading or lagging template DNA strand can initiate break-induced replication in fission yeast. Various nicking enzymes, including Cas9n...
www.cell.com
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Reposted by Anoop Chauhan
frezzalab.bsky.social
Christian Frezza @frezzalab.bsky.social · Nov 27
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition 🧪

Congrats @richpossemato.bsky.social & team for the very cool work!

www.nature.com/articles/s42...
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition - Nature Metabolism
Nam et al. show that limited glucose availability similar to the tumour microenvironment confers resistance against chemotherapeutic drugs that target DNA synthesis.
www.nature.com
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anoopsinghchauhan.bsky.social
Anoop Chauhan @anoopsinghchauhan.bsky.social · Nov 18
My first post on BlueSky.

Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases.
@drjhujh.bsky.social @profstewartlab.bsky.social
portlandpress.com/biochemj/art...
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease
Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that...
portlandpress.com
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Reposted by Anoop Chauhan
andrewblackford.bsky.social
Andrew Blackford @andrewblackford.bsky.social · Nov 13
Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL
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