Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

Stable isotope dilution mass spectrometry (IDMS) has become a cornerstone of quantitative metabolomics, enabling accurate intracellular metabolite quantification across a range of biological systems. ...

Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…

Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and s....

Researchers have developed a computer-guided method for designing and engineering bacteria that can detect the presence of specific molecules in the environment. This method will advance the use...

Zwei Cluster erhalten Förderung im wichtigsten deutschen Forschungswettbewerb

Computational modeling reveals how engineering plants with alternative pathways to photorespiration could boost crop yields.

Computational modeling reveals how engineering plants with alternative pathways to photorespiration could boost crop yields.

The transition from a petroleum-based manufacturing to biomanufacturing is an important step towards a sustainable bio-economy. In particular biotechnological processes which use one carbon (C1) compo...

Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for ...

For the first time, an international collaboration has demonstrated that synthetic carbon assimilation can operate more efficiently in a living system than its natural counterpart. Researchers in Tobias Erb’s lab at the Max Planck Institute for Terrestrial Microbiology engineered a synthetic metabolic pathway into a bacterium and showed in a direct comparison that it can generate significantly more biomass from the one-carbon compound formic acid and CO₂ than the natural bacterial strain.