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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 8

Please share: I am hiring a postdoc that will work on enzyme characterization and engineering in the frame of the EU consortium project C5.

Read all details here and apply until August 10: www.universiteitleiden.nl/en/vacancies...

Postdoctoral researcher on enzyme characterization and enzyme engineering

The Faculty of Science / the Institute for Biology is looking for a: Postdoctoral researcher on enzyme characterization and enzyme engineering Vacancy number: 15834 Project description We are hiring...

www.universiteitleiden.nl

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Reposted by Lennart Schada von Borzyskowski

Johannes Rebelein @rebeleinlab.bsky.social · Jul 3

Great collaboration with @lennartschada.bsky.social on an #enzyme converting the #plastic component ethylene glycol and to a feedstock chemical for microbes. Offering new ways to use plastic biotechnologically. 🧪

Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...

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Reposted by Lennart Schada von Borzyskowski

Cameron Thrash @jcamthrash.bsky.social · Jul 2

Ecogenomics and functional biogeography of the Roseobacter group in the global oceans based on 653 MAGs and SAGs www.biorxiv.org/content/10.1... #jcampubs 🌊

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

This work was largely carried out by Minrui Ren in my group at @unileiden.bsky.social and supported by collaborations with Timo Glatter and @rebeleinlab.bsky.social at @mpimicrobiomarburg.bsky.social and @synmikro.bsky.social as well as Meindert Lamers at LUMC and NeCEN.

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

This study paves the way towards applications of these enzymes in biocatalysis and metabolic engineering for sustainable production with PET-derived ethylene glycol as feedstock.

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

We also show that the transcriptional activator EtgR controls expression of the gene cluster. Bioinformatic analysis reveals that the etg gene cluster is widely distributed among bacteria, suggesting a common role of NAD-dependent dehydrogenases in ethylene glycol assimilation.

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

Using proteomics, we identify a gene cluster that is strongly expressed in the presence of ethylene glycol. We report the functional and structural characterization of EtgB and EtgA, key enzymes encoded by this etg gene cluster.

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jun 26

The project is coordinated by @tinadominguez.bsky.social and Henning Kirst at @uco.es and includes my group at @unileiden.bsky.social as well as the teams of Steffen Lindner at Charité, Maria Barbosa at @w-u-r.bsky.social, and Laura Martinelli at INsociety.
Looking forward to working together!

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jun 26

I am happy to share that a joint EIC Pathfinder Challenges project has been funded. The C5 consortium will develop disruptive technology for the sustainable production of isoprene from carbon dioxide.
Stay tuned for more updates and open positions.
cordis.europa.eu/project/id/1...

The C5 Pathfinder project aims to revolutionize the production of bio-based chemicals by leveraging synthetic compartmentalization and metabolic engineering within photosynthetic cyanobacterial system...

cordis.europa.eu

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Reposted by Lennart Schada von Borzyskowski

Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Jun 1

1/3 Although the issue of releasing GMOs for env bioremediation has been virtually absent of the mainstream scientific literature in Europe/US for >20 yrs, the topic has continued strong in Asia—alas in less fancy/visible journals. Time to revisit the subject in view of new global challenges 💪🏻!

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · May 19

This strain can degrade five recalcitrant pollutants simultaneously and was successfully tested with real-life industrial wastewater!

The study is nicely summarized in an article appearing in @chemistryworld.com, to which I contributed some comments: www.chemistryworld.com/news/enginee...

Engineered microbe could clean up persistent oil pollution hotspots

Bacterium can break down five hydrocarbon pollutants into harmless compounds

www.chemistryworld.com

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · May 19

Genetically enhanced bacteria can potentially become an effective tool for bioremediation in the future. Recently, an exciting breakthrough study about an engineered strain of the marine bacterium Vibrio natriegens was published in @nature.com: www.nature.com/articles/s41...

Bioremediation of complex organic pollutants by engineered Vibrio natriegens - Nature

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threat...

www.nature.com

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Mar 23

@dirktischler.bsky.social is opening the @vaam-microbes.bsky.social conference 2025 at @ruhr-uni-bochum.de. Looking forward to three days of presentations, posters, and networking!

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Lennart Schada von Borzyskowski @lennartschada.bsky.social · Mar 6

Only one week left to apply for this exciting PhD position, supervised by @gillesvanwezel.bsky.social and me!
Please apply if you are interested in microbial biochemistry and have a solid background in enzymes, metabolic pathways, and bacterial genetics.

www.universiteitleiden.nl/en/vacancies...

PhD aminosugar metabolism

The Faculty of Science / the Institute for Biology is looking for a :PhD Candidate , Aminosugar metabolism and control of growth and development in bacteriaVacancy number: 15487 PhD project descriptio...

www.universiteitleiden.nl

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Reposted by Lennart Schada von Borzyskowski

Erwan Rivault @erwanrivault.com · Jan 10

NEW: 2024 has just been confirmed as the warmest year on record, and the first to breach the 1.5C threshold.

We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940.

2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.

Ridgeline chart showing the distribution of global daily air temperature differences from the pre-industrial reference period (1850-1900), for every year between 1940 and 2024. Each individual year resembles a hill, shaded in a darker shade of red and further to the right for warmer years. The trend is clearly towards warmer years, with 2024 standing out as first year above 1.5C.

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Reposted by Lennart Schada von Borzyskowski

Brexit Bin 🇪🇺 🇬🇧 🇩🇪 @brexitbin.bsky.social · Jan 5

Here's the Chancellor candidate of the German Greens, Robert Habeck, stating what everyone needs to know. Namely that a strong EU is the best counterweight to authoritarians like Musk and Trump. Which is why they support those parties that want to weaken the EU.
[with English subtitles]

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Reposted by Lennart Schada von Borzyskowski

Angel Goñi-Moreno @angelgm.bsky.social · Dec 4

Synbio across environmental scales! By @ricardsole.bsky.social et al. doi.org/10.1021/acss...

Synthetic Ecosystems: From the Test Tube to the Biosphere

The study of ecosystems, both natural and artificial, has historically been mediated by population dynamics theories. In this framework, quantifying population numbers and related variables (associate...

doi.org

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Reposted by Lennart Schada von Borzyskowski

Paul Carini @uncultured.carinilab.com · Dec 3

Not all Bradyrhizobium fix N2! In fact, most that live in soil probably don’t. We isolated a bunch from Arizona soils and found none had N-fixing or nodulation genes. We report their genomes and phylogeny here in an accepted paper at access microbiology! www.microbiologyresearch.org/content/jour...

High-quality PacBio draft genome sequences of 17 free-living Bradyrhizobium and four related Nitrobacteraceae strains isolated from arid soils in the Santa Catalina Mountains of Southern Arizona.

Non-symbiotic Bradyrhizobium are among the most abundant and ubiquitous microbes in bulk soils globally. Despite this, most available genomic resources for Bradyrhizobium are derived from plant-associ...

www.microbiologyresearch.org

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Reposted by Lennart Schada von Borzyskowski

Micah G. Allen @micahgallen.com · Dec 2

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

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Reposted by Lennart Schada von Borzyskowski

Itai Yanai @itaiyanai.bsky.social · Nov 29

Which one are you?
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar

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Reposted by Lennart Schada von Borzyskowski

Mike Jetten @msmjetten.bsky.social · Nov 29

The denitrification ability and #nitrogen metabolism pathway of aerobic #denitrifier Marinobacter alkaliphilus SBY-1 under low C/N ratios doi.org/10.1016/j.sc...

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Reposted by Lennart Schada von Borzyskowski

Kat Toropova @kattoropova.bsky.social · Nov 24

Sign of the times, no more bluebird on the biorxiv engagement tab..

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Reposted by Lennart Schada von Borzyskowski

sevaplasmids.bsky.social @sevaplasmids.bsky.social · Nov 22

🌐 We just joined Bluesky! SEVA is a free, open-access plasmid repository and an international standard supporting the synthetic biology community. Catch us here! #SynBio ⬇️ seva-plasmids.com

Home - SEVA plasmids - Standard European Vector Architecture

Standard European Vector Architecture 4.0 Welcome to the CNB-hosted database and material repository of standard and modular plasmid vectors for (de/re) constructing complex bacterial phenotypes ...

seva-plasmids.com

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Reposted by Lennart Schada von Borzyskowski

Calin Plesa @calin.bsky.social · Nov 12

Started creating a synthetic biology starter pack. Still missing many so reply here if I forgot you or someone else.
go.bsky.app/SjfpxTK #synbio

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