Lightnews — Scholar-powered news

Johannes Rebelein @rebeleinlab.bsky.social · Jul 31

Fantastic work by the Ward lab to repurpose cytochrome #P450 enzymes for a new-to-nature asymmetric metal-catalysed H atom transfer! Just released
@Nature
: doi.org/10.1038/s415.... A must read!🧪

Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer - Nature

Cytochrome P450 enzymes can be repurposed to catalyse asymmetric metal–hydride hydrogen atom transfer, a new-to-nature reaction.

doi.org

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Johannes Rebelein @rebeleinlab.bsky.social · Jul 3

Great collaboration with @lennartschada.bsky.social on an #enzyme converting the #plastic component ethylene glycol and to a feedstock chemical for microbes. Offering new ways to use plastic biotechnologically. 🧪

Lennart Schada von Borzyskowski @lennartschada.bsky.social · Jul 1

Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...

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Johannes Rebelein @rebeleinlab.bsky.social · Jul 3

I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available in www.mpg.de/13631298/yea....

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Johannes Rebelein @rebeleinlab.bsky.social · Jun 13

A must read for anybody interested in the evolution of life and how to construct phylogenies using structures. Outstanding work by @georghochberg.bsky.social and co-worker. Congrats!

georghochberg.bsky.social @georghochberg.bsky.social · Jun 11

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

A general substitution matrix for structural phylogenetics.

Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

academic.oup.com

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Reposted by Johannes Rebelein

georghochberg.bsky.social @georghochberg.bsky.social · Jun 11

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

A general substitution matrix for structural phylogenetics.

Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

academic.oup.com

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Johannes Rebelein @rebeleinlab.bsky.social · Jun 2

Could you please add me.

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Johannes Rebelein @rebeleinlab.bsky.social · Jun 1

I am a microbiologist please add me www.mpi-marburg.mpg.de/859249/Johan...

Dr. J. Rebelein(Emmy Noether Research Group Leader)

www.mpi-marburg.mpg.de

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Johannes Rebelein @rebeleinlab.bsky.social · Jun 1

I am a biochemist www.mpi-marburg.mpg.de/859249/Johan...

Dr. J. Rebelein(Emmy Noether Research Group Leader)

www.mpi-marburg.mpg.de

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Johannes Rebelein @rebeleinlab.bsky.social · Jun 1

Leveraging spectroscopic and structural approaches we obtained new insights into the role of #ferredoxins in N2 fixation. Just published in Chemistry – A European Journal: doi.org/10.1002/chem...! Great work by Holly Addison. Fantastic collaboration with Antonio Pierik on the EPR characterization.

Two Key Ferredoxins for Nitrogen Fixation Have Different Specificities and Biophysical Properties

Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and s....

doi.org

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Reposted by Johannes Rebelein

Sven T. Stripp @stripplab.bsky.social · May 24

Marburg rules. I see @rebeleinlab.bsky.social @schullerjm.bsky.social @georghochberg.bsky.social in the crowd 😘

Olalla Vázquez @olallalab.bsky.social · May 24

YES!!!Excellent initiative #Microbes-for-Climate #M4C🦠FUNDED💲💰☺️🤩
The best?🤔The people❤️
Endless gratitude to Tobi & Anke - amazing role models❤️ Love the "thanks BBQ no matter what" spirit from the "Präsidium"! @unimarburg.bsky.social - sure it tasted better as we got it😉😂 #ProfLife #LovelyMarburg🏰❤️

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Reposted by Johannes Rebelein

James Birrell @jamesbirrell.bsky.social · May 10

Out now in @chemicalscience.rsc.org:

We apply 2DIR spectroscopy to study [FeFe] hydrogenase for the first time. Check it out!

pubs.rsc.org/en/content/a...

Two-dimensional Infrared Spectroscopy as a Tool to Reveal the Vibrational and Molecular Structure of [FeFe] Hydrogenases

[FeFe] hydrogenases are Nature’s most efficient catalysts for the cleavage and evolution of molecular hydrogen. Despite decades of research, key aspects of the catalytic cycle and the underlying geome...

pubs.rsc.org

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Reposted by Johannes Rebelein

Wim Meijer @wimgmeijer.bsky.social · May 4

The National Climate Assessment — already in the works for months — was gutted earlier this week, when President Trump’s administration dismissed hundreds of scientists working on it..

The National Nature Assessment was cancelled on his first day back in office..

🧪🦠

www.nature.com/articles/d41...

Trump gutted two landmark environmental reports — can researchers save them?

Scientists working on disrupted national climate and nature assessments aren’t giving up.

www.nature.com

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Reposted by Johannes Rebelein

David Ho @davidho.bsky.social · May 4

I think a lot about what Carl Sagan said in one of his final interviews.

"WE'VE ARRANGED A society based on science and technology, in which nobody understands anything about science technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces. Who is running the science and technology in a democracy if the people don't know anything about it?"
"Science is more than a body of knowledge, it's a way of thinking. A way of skeptically interrogating the universe with a fine understanding of human fallibility. If we are not able to ask skeptical questions, to interrogate those who tell us that something is true, to be skeptical of those in authority, then we're up for grabs for the next charlatan, political or religious, who comes ambling along."

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Reposted by Johannes Rebelein

Martin Thanbichler @thanbichlerlab.bsky.social · May 1

*** Only a few days left to apply ***

Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"

Spatiotemporal regulation of cellular processes by CTP-switches in bacteria

Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

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Reposted by Johannes Rebelein

Tom Ellis @proftomellis.bsky.social · May 2

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

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Johannes Rebelein @rebeleinlab.bsky.social · May 3

Exciting work from @frunzkelab.bsky.social and @borjana-a.bsky.social at @fz-juelich.de

Julia Frunzke @frunzkelab.bsky.social · May 3

New preprint from @erdrich-science.bsky.social of our collaborative project with @borjana-a.bsky.social, @fz-juelich.de and @guidogrossmann.bsky.social @hhu.de:

"Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence"
www.biorxiv.org/content/10.1...

Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence

Bacteriophages are increasingly recognized as key players in modulating plant-microbe interactions, including their potential in the biocontrol of plant pathogenic bacteria. In this study, we investig...

www.biorxiv.org

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Reposted by Johannes Rebelein

Julia Frunzke @frunzkelab.bsky.social · May 3

New preprint from @erdrich-science.bsky.social of our collaborative project with @borjana-a.bsky.social, @fz-juelich.de and @guidogrossmann.bsky.social @hhu.de:

"Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence"
www.biorxiv.org/content/10.1...

Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence

Bacteriophages are increasingly recognized as key players in modulating plant-microbe interactions, including their potential in the biocontrol of plant pathogenic bacteria. In this study, we investig...

www.biorxiv.org

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Johannes Rebelein @rebeleinlab.bsky.social · May 3

Exciting work by Ribbe & Hu lab demonstrating the in vivo reduction of N2 by L-cluster containing Nif(EN)2 inside E. coli: www.science.org/doi/10.1126/... This finding suggests a smaller minimal gene set for the heterologous expression of #nitrogenase and an easier route to synthetic #N2-fixation

Heterologous synthesis of a simplified nitrogenase analog in Escherichia coli

Heterologous synthesis of a nitrogenase analog (NifH/NifEN) in E. coli enables N2 reduction and incorporation of N into biomass.

www.science.org

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Johannes Rebelein @rebeleinlab.bsky.social · May 3

Great work Adrian!

Adrian Bunzel @bunzela.bsky.social · Apr 30

🚨Out now in Angewandte Chemie:

AI.zymes - A modular platform for evolutionary enzyme design.

AI.zymes integrates established and emerging bioengineering tools into a coherent pipeline for #enzymedesign.

📄Paper: doi.org/10.1002/anie...
💻GitHub: github.com/bunzela/AIzy...

Reposted by Johannes Rebelein

Cameron Thrash @jcamthrash.bsky.social · Apr 29

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research www.nature.com/articles/s41... #jcampubs

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology

Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

www.nature.com

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Johannes Rebelein @rebeleinlab.bsky.social · Apr 21

This title is at best misleading. The word fertilizer probably suggests to most readers that fungi can fix molecular nitrogen (N2) to ammonia (NH3),which is not the case. So the impact of that finding is debatable...

Reposted by Johannes Rebelein

Reinhard Steurer @steurer.bsky.social · Apr 20

Gab es dazu wirklich KEINE Berichterstattung? Eine Google-News Suche zu CO2-Konzentration liefert nur Ergebnisse zu einem UN-Bericht aus 2024. Keine Studie, keine News? Außer natürlich bei BIP, Inflation, Arbeitslosigkeit... 😬 Bitte gerne Links darunter posten.

Reinhard Steurer @steurer.bsky.social · Apr 14

Wahnsinn. Dieser nie dagewesene Anstieg der CO2-Konzentration in einem Jahr ist jenseits aller Erwartungen und müsste in zig Sondersendungen erörtert werden, wenn wir als Gesellschaft noch bei Trost wären. Müsste... gml.noaa.gov/ccgg/trends/...

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Reposted by Johannes Rebelein

Chris Greening @greening.bsky.social · Mar 20

Energy from air? No problem! In our new preprint, we reconstitute the machinery that allows microbes to endure starvation. By using the trace amounts of hydrogen in air alone, they produce plenty of chemical energy (2 ATP) to get by. The only byproduct? Water. www.biorxiv.org/content/10.1...

Hydrogenase-driven ATP synthesis from air

All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The universally conserved F1Fo-ATP synthase regenerates ATP...

www.biorxiv.org

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Reposted by Johannes Rebelein

Ben Engel @cellarchlab.com · Jan 6

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇

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Reposted by Johannes Rebelein

Schuller Jan @schullerjm.bsky.social · Apr 16

One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today!
www.nature.com/articles/s41...

Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature

The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...

www.nature.com

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