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Reposted by Anne-Laure Boulesteix

Georg Heinze @georgheinze.bsky.social · Jun 26

Comment by the STRATOS initiative: (including @boulesteixlaure.bsky.social @mhstat.bsky.social) onlinelibrary.wiley.com/doi/10.1002/... (6/8)

Commentary: Regression Models—Efforts Are Required to Improve Statistical Practice and Teaching

Click on the article title to read more.

onlinelibrary.wiley.com

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Jun 23

For researchers with limited background in statistics, we have written this gentle introduction to simulation studies (with @timpmorris.bsky.social and other people from the STRATOS initiative):
bmjopen.bmj.com/content/10/1...

Introduction to statistical simulations in health research

In health research, statistical methods are frequently used to address a wide variety of research questions. For almost every analytical challenge, different methods are available. But how do we choos...

bmjopen.bmj.com

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Mark Rubin @markrubin.bsky.social · May 23

Workshop on “Evidence & Uncertainty in Science: Methodological, Philosophical and Meta-Scientific Issues”

10th & 11th June, Uni of Tübingen, in-person only

uni-tuebingen.de/de/281247#c2...

‪With @cruwelli.bsky.social, @boulesteixlaure.bsky.social, @babeheim.bsky.social, & @hendriks.bsky.social ‬

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Florian Naudet @floriannaudet.bsky.social · Mar 20

French scientist denied US entry after phone messages critical of Trump found

France’s research minister said the scientist was traveling to Houston for a conference when his phone was searched

www.theguardian.com

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Mar 13

Probably because it is a big effort to check the code? Biometrical Journal does it. They have reproducibility editors who do excellent job. As an AE or reviewer for any journal, I always require code to be available.

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Mar 12

NEW (METASCIENTIFIC) PREPRINT on the exploratory/confirmatory distinction:

Title: On "confirmatory" methodological research in statistics and related fields

by @iamjulianlange.bsky.social J. Wilcke, @sabinehoffmann11.bsky.social M. Herrmann and myself

arxiv.org/abs/2503.08124

On "confirmatory" methodological research in statistics and related fields

Empirical substantive research, such as in the life or social sciences, is commonly categorized into the two modes exploratory and confirmatory, both of which are essential to scientific progress. The...

arxiv.org

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Mar 7

NEW METASCIENTIFIC PREPRINT: "The impact of the storytelling fallacy on real data examples in methodological research" by M. Mandl et al:

arxiv.org/html/2503.03...

or why it is misleading to argue in favor of a method just because one can tell a nice story on the results obtained for n=1 dataset.

The impact of the storytelling fallacy on real data examples in methodological research

arxiv.org

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Mar 5

SPOILER: Forget "naive" confidence intervals computed by considering the results in the K folds as iid observations...

The K folds in K-fold-cross-validation are NOT independent!
And this cannot just be ignored...

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Mar 5

NEW PAPER: Confidence intervals for (e.g., cross-validation) prediction error

by H. Schulz-Kümpel, S. Fischer et al.

"Constructing confidence Intervals for “the” Generalization
Error – a Comprehensive Benchmark Study"

openreview.net/pdf?id=x7kCj...

openreview.net

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Alfredo Sánchez-Tójar @asanchez-tojar.bsky.social · Feb 7

This Registered Report masterpiece just dropped at BMC Biology, brilliantly led by a great team with the help of 300+ analysts & reviewers

Same question, same data: go figure!

tl;dr: Substantial heterogeneity among results comes from differences among analytical choices

🔗 doi.org/10.1186/s129...

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Stephen Senn @stephensenn.bsky.social · Nov 25

IMO it’s a mistake to give stats to 1st year med students. It’s not why they chose medicine & they resent it. Better to wait until they have developed some curiosity for it. I argued unsuccessfully for this during my time at UCL.

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Miguel Hernan @miguelhernan.org · Nov 26

Does #randomization ensures balance of risk factors between groups? Consider this:

In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)

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Malika Ihle @malikaihle.bsky.social · Nov 19

So happy to see you all here! As the @lmu-osc.bsky.social coordinator, I just started a new project: coaching individual research groups so members can switch together to #OpenResearch - a tailored pedagogical intervention to maximise chances of sustainable adoption in the group, and a lot of fun! 🧵

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Nov 19

I could nnot agree more. One problem is that for some packages (not those you are involved in ;-)) it is difficult to figure out which method/theory they implement. The link between theory and implementation is not well documented. So people just mention the package name in place of the method...

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Wolfgang Huber @wkhuber.bsky.social · Nov 19

Something that's been bugging me for a while in bioinformatics data analysis is this overreliance on packages, workflows and what's been called "cargo cult science".

Can we have more conceptual thinking, more theory?
Asking for what we really want to achieve and what we need to do gets us there.

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Anne-Laure Boulesteix @boulesteixlaure.bsky.social · Nov 18

Happy to have been involved in this exciting project on the registration, design and reporting of statistical simulation studies, with @bsiepe.bsky.social @timpmorris.bsky.social et al., appeared in Psychological Methods:

Björn Siepe @bsiepe.bsky.social · Nov 18

Journal version at doi.org/10.1037/met0..., final openly available version at doi.org/10.31234/osf....
I have learned a lot from this collaboration, which started with a cold email at the beginning of my PhD - very much worth it

APA PsycNet

doi.org

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Wolfgang Huber @wkhuber.bsky.social · Nov 18

AI researchers: hold my beer —
Old model performed slightly not worse when data were generated by the new generative AI method I just made up

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Maarten van Smeden @maartenvsmeden.bsky.social · Nov 18

I made one for stats papers

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Björn Siepe @bsiepe.bsky.social · Nov 18

Simulation studies are essential for methods research. How well are they conducted & reported? How can we improve their quality? Out now in Psychological Methods, see 🧵 below.
With @fbartos.bsky.social, @timpmorris.bsky.social, @boulesteixlaure.bsky.social, @danielheck.bsky.social & Samuel Pawel

Björn Siepe @bsiepe.bsky.social · Oct 31

We reviewed 100 psych. simulation studies & find room for improvement in planning/reporting. As a remedy, we (František Bartoš, @timpmorris.bsky.social Anne-Laure Boulesteix, @danielheck.bsky.social & Samuel Pawel) present ADEMP-PreReg, a simulation study preregistration & reporting template 🧵/1

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Richard Riley (R²) @richarddriley.bsky.social · Nov 14

MEMTAB 2025 pre-conference courses news!

2 options:
- An Introduction to Clinical Prediction Models and Sample Size Calculations for Model Development & Evaluation
- Systematic Reviews of Prognosis Studies

Just £50 when registering for conference!

Details 👇
uobevents.eventsair.com/memtab-2025/...

Pre-conference Courses - MEMTAB 2025

uobevents.eventsair.com

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Pausal Zivference @pausalz.bsky.social · Nov 14

We must stand against the arbitrary categorization of continuous variables!

... and that's why I'm proud to announce my support of abolishing time zones in favor of the time gradient

Two maps the the contiguous United States. The first is colored with the 4 time zones. Above that map states "say no to time zones". The bottom is the same map but with a continuous color gradient. Above that map states "say yes to the time gradient"

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Maarten van Smeden @maartenvsmeden.bsky.social · Nov 11

Which reminds me of this Andrew Vickers quote
www.nature.com/articles/ncp...

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Wolfgang Huber @wkhuber.bsky.social · Nov 1

Independent GroupLeader / PI position in
AI in Genome Biology, Multimodal Omics
at European Molecular Biology Lab (EMBL), Heidelberg!
www.embl.org/jobs/positio...

Looking in particular for researchers with quantitative/ methodological background who want to dive into leading edge biology research.

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Wolfgang Huber @wkhuber.bsky.social · Oct 21

For all the new followers here: welcome!
Here some recent highlights:
(1/4) My eclectic and subjective list of scientific writing tips

Scientific writing tips – Huber Group @ EMBL

An eclectic and subjective list

www.huber.embl.de

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Hugh Shanahan @hughshanahan.bsky.social · Oct 28

Bias in the evaluation of female academics is hard to remove

www.forbes.com/sites/kimels...

College Professors Tried To Reduce Gender Bias In Evaluations—But Couldn’t

Hamilton College researchers tested strategies to reduce gender bias in student evaluations, but their efforts failed, highlighting how deeply ingrained bias remains.

www.forbes.com

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