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Caro Kobras 🐍 @carokobras.bsky.social · 7d

Ha! And they say romance is dead ❤️🌹

Reposted by Caro Kobras 🐍

Andy Edwards @bugsinblood.bsky.social · 9d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Reposted by Caro Kobras 🐍

(GIRISH)MALI LAB @dyneinassembly.bsky.social · 9d

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

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Reposted by Caro Kobras 🐍

Microbes in Health and Disease @mhd-newcastle.bsky.social · 9d

Dr Manuel Banzhaf

The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments.

Follow @banzhaflab.bsky.social for more updates

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Reposted by Caro Kobras 🐍

Nature Structural & Molecular Biology @natsmb.nature.com · 9d

New online: Molecular basis for the activation of outer dynein arms in cilia

Molecular basis for the activation of outer dynein arms in cilia

Nature Structural & Molecular Biology, Published online: 29 September 2025; doi:10.1038/s41594-025-01680-9Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.

go.nature.com

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Reposted by Caro Kobras 🐍

Susanne Gebhard @gebhardlab.bsky.social · 12d

New preprint out from the team! Master‘s student extraordinaire Julia Bauer stumbled across a Ca transporter needed for endospore maturation in Solibacillus 🧫🔬 www.biorxiv.org/content/10.1...

Decoding the functional role of the calcium ATPase YloB in microbially induced calcite precipitation and sporulation in Solibacillus silvestris

Calcium homeostasis is essential for bacterial physiology, yet its regulation and role in specialized processes such as microbially induced calcite precipitation (MICP) and sporulation remain poorly u...

www.biorxiv.org

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Reposted by Caro Kobras 🐍

The Dunn School, Oxford @dunnschool.bsky.social · 28d

We're hiring (again)!

We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)

If you have a great record and exciting plans, consider joining our thriving and welcoming department

www.path.ox.ac.uk/vacancy/asso...

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Reposted by Caro Kobras 🐍

Kat Toropova @kattoropova.bsky.social · Sep 8

The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...

How to Apply - Dunn School

Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.

www.path.ox.ac.uk

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Reposted by Caro Kobras 🐍

Henrik Strahl @henrikstrahl.bsky.social · Aug 22

A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...

Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures

Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...

www.biorxiv.org

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Reposted by Caro Kobras 🐍

Rob Fagan @robfagan.bsky.social · Aug 22

New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change

@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social

A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile

The glycopeptide antibiotic vancomycin is the frontline treatment for C. difficile infection in the UK. There have been only sporadic reports of resistance in the clinic but testing is rare so the tru...

www.biorxiv.org

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Reposted by Caro Kobras 🐍

Melissa Webby @melissawebby.bsky.social · Aug 15

🦠 A fan of bacteria?
We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social

Positive, organised, skills in molecular biology and protein purification?

Apply here 👉 warwick-careers.tal.net/vx/appcentre...

Please share! 🔬

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Reposted by Caro Kobras 🐍

Emily Goodall @emgoodall.bsky.social · Aug 14

Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...

PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes

Abstract. The advent of high-density mutagenesis and data-mining studies suggest the existence of further coding potential within bacterial genomes. Small

academic.oup.com

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Reposted by Caro Kobras 🐍

Helmholtz-Zentrum für Infektionsforschung (HZI) @helmholtzhzi.bsky.social · Jul 29

Sinkende #Impfquoten verschärfen auch die Antibiotikaresistenz-Krise: Denn virale Infektionen wie #Masern können nicht selten zu bakteriellen Folgeerkrankungen führen - oft behandelt mit #Antibiotika. @ca.theconversation.com berichtet. #AMR theconversation.com/how-falling-...

How falling vaccination rates are fuelling the antibiotic resistance crisis

Measles is a viral infection, so antibiotics don’t treat it directly. But it weakens the immune system, leading to bacterial infections like pneumonia or ear infections, which do require antibiotics.

theconversation.com

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Reposted by Caro Kobras 🐍

John Helmann @johnhelmann.bsky.social · Jul 28

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals

rdcu.be/eycU2

Microbial metal physiology: ions to ecosystems

Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...

rdcu.be

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Reposted by Caro Kobras 🐍

Lilly Cummins @lillycummins.bsky.social · Jul 23

🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec

This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n

www.biorxiv.org/content/10.1...

Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)

Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...

www.biorxiv.org

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Reposted by Caro Kobras 🐍

Em Stevens @emstevens93.bsky.social · Jun 18

I'm very pleased to share the latest paper from my post doc with @kayla-king.bsky.social. We looked at how host microbiota can influence pathogen virulence evolution in a C. elegans model of infection: academic.oup.com/ismej/articl...

Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis

Abstract. Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outco

academic.oup.com

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Caro Kobras 🐍 @carokobras.bsky.social · May 7

Thank you so much @melissawebby.bsky.social 😌 🥰 - biggest cheerleader and a super successful scientist herself!! 👩‍🔬

Melissa Webby @melissawebby.bsky.social · May 7

Just @carokobras.bsky.social doing amazing stuff! She is a fantastic scientist and wonderful person. If you don't already follow her you should because she has some really exciting science on the way!

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Reposted by Caro Kobras 🐍

Melissa Webby @melissawebby.bsky.social · May 7

Just @carokobras.bsky.social doing amazing stuff! She is a fantastic scientist and wonderful person. If you don't already follow her you should because she has some really exciting science on the way!

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Caro Kobras 🐍 @carokobras.bsky.social · Apr 18

Congrats to all fellow fellows 🎉🥳 and thanks to @dunnschool.bsky.social for funding the work leading up to my proposal ☺️

The Dunn School, Oxford @dunnschool.bsky.social · Apr 17

‪
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳

A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!

Check the full list here: www.path.ox.ac.uk/news-article...

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Caro Kobras 🐍 @carokobras.bsky.social · Apr 17

Thanks! Sorry, didn’t quite click when I bumped into you: Congrats to you, too! 💪

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Caro Kobras 🐍 @carokobras.bsky.social · Apr 17

Super excited to have been awarded a 2024 BBSRC Fellowship to investigate antibiotic tolerance in staphylococci! ☺️🧫🦠💊 @ukri.org

Very grateful for all the support I have received!!

www.ukri.org/news/9-milli...

£9 million investment fuels groundbreaking bioscience research

From unlocking the secrets of animal movement to tackling antimicrobial resistance, UK’s brightest bioscience minds are pushing the boundaries of innovation.

www.ukri.org

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Reposted by Caro Kobras 🐍

Andreas Peschel @andreaspeschel.bsky.social · Apr 16

www.science.org/doi/10.1126/...

Control of morphogenesis during the Staphylococcus aureus cell cycle

Staphylococcus aureus tightly controls division proteins to maintain cell morphology during the cell cycle.

www.science.org

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Reposted by Caro Kobras 🐍

Nature Microbiology @natmicrobiol.nature.com · Jan 13

💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here...
www.nature.com/articles/s41...

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology

An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...

www.nature.com

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Reposted by Caro Kobras 🐍

Csaba Pal Laboratory @csabapallab.bsky.social · Feb 24

🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...

Exploring the principles behind antibiotics with limited resistance - Nature Communications

This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...

www.nature.com

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Reposted by Caro Kobras 🐍

Isabella Tomanek @bellatom.bsky.social · Feb 26

Come join our fun community @ox.ac.uk! Two postdoc positions available in the fabulous Slack and Foster labs www.fosterlab.uk/vacancies

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