Claudine Prud’homme
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clau-prudhomme.bsky.social
Claudine Prud’homme
@clau-prudhomme.bsky.social
160 followers 340 following 38 posts
#MECFS #POTS #Fibro patient/atteinte d’EM/POTS/Fibro- since 2008 🇨🇦

New caregiver of my 19yr old son with severe #LONGCOVID/ME #POTS 😢😭

Former veterinarian
Membre comité scientifique AQEM-
post infectious illness interest
Posts Replies Media Videos
Reposted by Claudine Prud’homme
tomkindlon.bsky.social
#MyalgicEncephalomyelitis #PwME #MEcfs #CFS
The fact I want everyone to know this World ME Day is .... Fact: ME is an incapacitating illness. "No-one wants to be ill with this. It has robbed us of careers, income, relationships, becoming parents, having a spouse; being able to spontaneously go on a trip, to a concert, show, hike, dance, or whatever other enjoyable thing used to do. We live small limited lives in our h and for some confined to bed. We all exist with clipped wings, wishing only to be free. ANZMES member
August 28, 2025 at 9:18 PM
Reposted by Claudine Prud’homme
tomkindlon.bsky.social
Summaries of presentations made at the recent Patient-Led Research Collaboration (PLRC) @patientled.bsky.social conference

solvecfs.org/plrf-event-h...

Prepared by Solve ME/CFS Initiative @solveme.bsky.social

#LongCovid #MEcfs
PLRF Event Highlights Promising ME/CFS & Long Covid Biomedical Research Projects July 24, 2025 8:24 pm On July 9, the Patient-Led Research Collaborative (PLRC) hosted an online presentation by researchers funded by the inaugural Patient-led Research Fund (PLRF). Ms. Gina Assaf, one of the PLRC founders, started the afternoon by reviewing how the PLRC began and the PLRC’s overarching goals. In April 2020, Gina explained, a group of people from countries all around the world and from diverse professional backgrounds banded together to document their experiences having Long COVID. This informal group grew into the PLRC, whose mission is to represent people with Long COVID and other infection-associated chronic conditions through research in which patients help conduct, through medical education, and through advocacy grounded in patients’ firsthand experiences. Even today, each PLRC team member is a patient with Long COVID or Long COVID–related condition.
August 13, 2025 at 11:17 PM
Reposted by Claudine Prud’homme
bmhughes.bsky.social
Proud to be on the Science Advisory Board for DecodeME, a peripheral role but a fantastic vantage point from which to witness such outstanding work by Chris Ponting @cgatist.bsky.social and colleagues

#MECFS #pwME

www.theguardian.com/society/2025...
Scientists find link between genes and ME/chronic fatigue syndrome
Large study suggests people’s genetics could ‘tip the balance’ on whether they would develop the illness
www.theguardian.com
August 6, 2025 at 8:16 PM
Reposted by Claudine Prud’homme
tomkindlon.bsky.social
Interesting new research from Spain:

Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera.

iopscience.iop.org/article/10.1...

#LongCovid #PASC #postcovid #postcovid19 #MEcfs #CFS #PwME
Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID-19 (LC-19) are complex conditions with no diagnostic markers or consensus on disease progression. Despite extensive research, no in vitro model exists to study skeletal muscle wasting, peripheral fatigue, or potential therapies. We developed 3D in vitro skeletal muscle tissues to map muscle adaptations to patient sera over time. Short exposures (48 hours) to patient sera led to a significant reduction in muscle contractile strength. Transcriptomic analysis revealed the upregulation of glycolytic enzymes, disturbances in calcium homeostasis, hypertrophy, and mitochondrial hyperfusion. Structural analyses confirmed myotube hypertrophy and elevated mitochondrial oxygen consumption in ME/CFS. While muscles initially adapted by increasing glycolysis, prolonged exposure (96–144 hours) caused muscle fragility and fatigue, with mitochondria fragmenting into a toroidal conformation. We propose that skeletal muscle tissue in ME/CFS and Long COVID-19 progresses through a hypermetabolic state, leading to severe muscular and mitochondrial deterioration. This is the first study to suggest such transient metabolic adaptation.
August 1, 2025 at 1:29 PM
Reposted by Claudine Prud’homme
abrokenbattery.bsky.social
Flawed science can shape medicine for decades. In this new investigation, @davetuller1.bsky.social shows how debunked psychosomatic theories from #MECFS are now being used to dismiss #LongCovid. When belief trumps evidence, patients suffer.

www.openmindmag.org/articles/goi...
David Tuller (@davetuller1.bsky.social)
Senior Fellow in Public Health and Journalism, Center for Global Public Health at the University of California, Berkeley. I blog at Virology Blog (virology.ws). My academic position is largely funded ...
davetuller1.bsky.social
May 27, 2025 at 1:14 PM
Reposted by Claudine Prud’homme
aqem.bsky.social
Ce chantier de traduction est une des initiatives entreprises par l'AQEM pour soutenir la communauté cette année.

Il vise à ce que davantage d'informations essentielles puissent être accessibles aux personnes atteintes de langue française.

👉 Suivez-nous pour connaître les prochaines traductions!
Illustration d'une personne non-genrée, assise par terre avec ses jambes croisées, travaillant avec un portable sur ses jambes. Derrière la personne est un très grand livre sur lequel il est écrit "Nouvelle ressource, Guide de survie en cas de crash". Sur le livre il y a le logo de l'AQEM et le logo du Bateman Horne Centre.
January 27, 2025 at 5:00 PM
Reposted by Claudine Prud’homme
aqem.bsky.social
Le "Guide de survie en cas de crash" a été conçu par le @batemanhornecenter.bsky.social pour soutenir les #PAEM, leurs proches et leur équipe soignante à comprendre la maladie et à se préparer à répondre aux besoins essentiels en cas de crash.

👉 tinyurl.com/GuideCrash

C’est une petite mine d’or!
Illustration d'une personne non-genrée, assise par terre avec ses jambes croisées, travaillant avec un portable sur ses jambes. Derrière la personne est un très grand livre sur lequel il est écrit "Nouvelle ressource, Guide de survie en cas de crash". Sur le livre il y a le logo de l'AQEM et le logo du Bateman Horne Centre.
January 27, 2025 at 5:00 PM
Reposted by Claudine Prud’homme
aqem.bsky.social
📢 Nouvelle ressource : Guide de survie en cas de crash

👉 tinyurl.com/GuideCrash

Ce guide du @batemanhornecenter.bsky.social, traduit en français avec leur autorisation, est un outil fondamental pour la vie avec l' #EMSFC et la #CovidLongue.

✨ N’hésitez pas à le partager.
Illustration d'une personne non-genrée, assise par terre avec ses jambes croisées, travaillant avec un portable sur ses jambes. Derrière la personne est un très grand livre sur lequel il est écrit "Nouvelle ressource, Guide de survie en cas de crash". Sur le livre il y a le logo de l'AQEM et le logo du Bateman Horne Centre.
January 27, 2025 at 5:00 PM
Reposted by Claudine Prud’homme
valebodi.bsky.social
Just published! Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls www.nature.com/articles/s41... @buonsenso.bsky.social et al. in @nature.com #LongCOVIDKids
Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls - Pediatric Research
Pediatric Research - Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls
www.nature.com
January 25, 2025 at 12:43 AM
clau-prudhomme.bsky.social
« These findings suggest that hippocampal alterations may contribute to the neurocognitive impairment experienced by long COVID and ME/CFS patients. »

journals.plos.org/plosone/arti...
Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study
Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients share similar symptoms including post-exertional malaise, neurocognitive impairment, and memory loss. The neurocogni...
journals.plos.org
January 16, 2025 at 3:54 PM
Reposted by Claudine Prud’homme
nikosuvisto.com
I feel numb all the time. You have to detach yourself from the reality because it’s too painful to live like this. ME/CFS does this to you—it makes you feel empty. 1/9

#MECFS #pwME #photography #selfdocumentary
A black and white image. The author of the post is laying in bed, he’s a man in his 30s. He has a beard and a moustache. You can see his head and part of the shoulders. His head is turned sideways and his looking at the distance. The picture is dark, the harsh light is hitting his head and lighting his facial features, like his Roman nose. He is positioned in the left side of the photo and is looking at that direction. Behind his head is a lot of negative space, there is a part of his pillow, that is under is head, and part of the bed is shown.
January 14, 2025 at 1:00 PM
Reposted by Claudine Prud’homme
tomkindlon.bsky.social
Well done to Mark Vink on getting another piece published: this one has the provocative title, "CBT and graded exercise therapy studies have proven that ME/CFS and long Covid are physical diseases, yet no one is aware of that"

www.frontiersin.org/journals/hum...

#MEcfs #CFS #PwME
Frontiers | CBT and graded exercise therapy studies have proven that ME/CFS and long Covid are physical diseases, yet no one is aware of that
The cognitive behavioral model (CBmodel) (1,2) has dominated the world of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) since the 1990s. Accord...
www.frontiersin.org
January 15, 2025 at 5:08 PM
clau-prudhomme.bsky.social
ME/CFS leaders knew from the beginning of the pandemic there will be an increase of #MECFS cases after a COVID infection.

« Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study »

link.springer.com/article/10.1...
Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study - Journal of General Internal Medicine
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown. Objective To determine the inci...
link.springer.com
January 13, 2025 at 9:05 PM
Reposted by Claudine Prud’homme
batemanhornecenter.bsky.social
In our latest blog, Suzanne Vernon, PhD, discusses the RESTORE ME study & oxaloacetate in ME/CFS.

📖 Dr. Vernon’s blog post:
bit.ly/4haLHDB
🎥 Watch Jarrod Younger's YouTube: bit.ly/3WcynGN
📖 Read Cort Johnson’s blog post: bit.ly/3PtUtRq

#MECFS #LongCOVID #ClinicalTrials #Oxaloacetate #BHC
January 10, 2025 at 4:21 PM
Reposted by Claudine Prud’homme
valebodi.bsky.social
A 2024 #MECFS Year in Review Points to Progress – A Profound Disruption in Energy Production www.healthrising.org/blog/2025/01... In study after study, two themes popped up again & again. Cells across #pwME’s bodies are exhausted & exhibit a “failure to respond” when exposed to stress"
A 2024 ME/CFS Year in Review Points to Progress - and a Profound Disruption in Energy Production - Health Rising
A year in review for chronic fatigue syndrome or ME/CFS findings evidence of cellular exhaustion in many levels caused by mitochondrial dysfunction.
www.healthrising.org
January 5, 2025 at 6:24 PM
Reposted by Claudine Prud’homme
sunsopeningband.bsky.social
Where I think it’s all headed for ME and ME-like diseases: mitochondrial transfer. Affected cell lines may receive donations from less affected ones. Treatments may focus on providing reinforcements for those poor, de-energized little beans. 🫘 translational-medicine.biomedcentral.com/articles/10....
Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment - Journal of Translational Medicine
Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular d...
translational-medicine.biomedcentral.com
January 5, 2025 at 9:08 PM
clau-prudhomme.bsky.social
A little reminder from me to me. Even after 16 years of ME/CFS, many of the resolutions described are still hard to keep. #MECFS #ME #LongCovid #Chronicillness
themighty.com/topic/chroni...
The New Year’s Resolutions of a Chronically Ill Person
What would you add?
themighty.com
January 5, 2025 at 3:19 AM
Reposted by Claudine Prud’homme
kgandersen.bsky.social
A very good article from @cohenjon.bsky.social with lots of hard-hitting quotes, including:

“Everyone is acting as though this pandemic didn’t really happen.”

… from Van Kerkhove. Spot on.

www.science.org/content/arti...
COVID 5 years later: Learning from a pandemic many are forgetting
Five years after SARS-CoV-2 surfaced, scientists reflect and look ahead to the next threat
www.science.org
January 2, 2025 at 6:41 PM
clau-prudhomme.bsky.social
More than “Brain Fog” journals.lww.com/cptj/fulltex...
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
e activity is considered when working with people with long COVID, particularly when identifying triggers of post exertional symptom exacerbation. There are many potential mechanisms that could be dri...
journals.lww.com
January 1, 2025 at 2:57 PM
Reposted by Claudine Prud’homme
dbkell.bsky.social
Let's hope that 2025 is the year in which science helps folk with #LongCOVID. A start at journals.lww.com/cptj/fulltex... with @CiaraGlenville, @resiapretorius and @PutrinoLab. #TeamClots
Treatment of Long COVID With Enoxaparin : Cardiopulmonary Physical Therapy Journal
symptoms, via reduced blood flow and cellular energy production. Postexertional malaise (PEM) is common and exercise therapy should not be recommended without addressing the underlying pathology. Cas...
journals.lww.com
December 30, 2024 at 5:26 PM
Reposted by Claudine Prud’homme
longcovidphysio.bsky.social
We promised that the #LCPForum was research generating …

… so here it is 💙📰

Priorities for Research, Education, Clinical Practice, and Policy From the Long COVID Physio International Forum

#LongCOVID

journals.lww.com/cptj/fulltex...
Priorities for Research, Education, Clinical Practice, and... : Cardiopulmonary Physical Therapy Journal
litation. Methods: We conducted an international consultation on priorities for long COVID and rehabilitation with people living with long COVID, clinicians, researchers, and other key interest-hol...
journals.lww.com
December 30, 2024 at 7:17 PM
Reposted by Claudine Prud’homme
tomkindlon.bsky.social
New from Germany:

Autoantibodies to Arginine-rich Sequences Mimicking Epstein-Barr Virus in Post COVID & ME / #CFS

www.medrxiv.org/content/10.1...

"Several autoantibodies were positively associated with key symptoms of autonomic dysfunction, fatigue, cognition, & pain"

#LongCovid #MEcfs
Screenshot of abstract
January 1, 2025 at 1:36 PM
clau-prudhomme.bsky.social
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence onlinelibrary.wiley.com/doi/10.1002/...
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pa...
onlinelibrary.wiley.com
December 28, 2024 at 2:38 PM
clau-prudhomme.bsky.social
Wish you all Merry Christmas, specially those who have disabilities and are alone in this period of the year. May the 2025 be better for all of you 💙🎄🎁
December 25, 2024 at 5:28 PM
clau-prudhomme.bsky.social
💔💔💔
meactnet.bsky.social #MEAction Network @meactnet.bsky.social · Dec 22
It is with deep sadness that we share with you that we lost one of our heroes and champions of ME yesterday. Beth Mazur passed away after battling ME for 15 years. She was a selfless beacon of hope & light in our community. She demonstrated an unwavering commitment to the cause.
Beth Mazur smiling a big beautiful smile
December 23, 2024 at 5:51 PM