Cole J. Batty
@colebatty.bsky.social
NIH T32 Fellow in the Marasco Lab at Dana Farber/Harvard Medical School studying B cells in aging
Reposted by Cole J. Batty
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
November 26, 2025 at 8:41 PM
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
Reposted by Cole J. Batty
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
November 1, 2025 at 10:16 PM
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1
Reposted by Cole J. Batty
Autoantibody origins in lupus and in relapse post CAR-T therapy https://www.biorxiv.org/content/10.1101/2025.10.20.683393v1
October 20, 2025 at 10:16 PM
Autoantibody origins in lupus and in relapse post CAR-T therapy https://www.biorxiv.org/content/10.1101/2025.10.20.683393v1
Cooler techniques available every day!
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Integrated epigenetic and genetic programming of primary human T cells - Nature Biotechnology
Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
go.nature.com
October 21, 2025 at 4:04 PM
Cooler techniques available every day!
Reposted by Cole J. Batty
Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells https://www.biorxiv.org/content/10.1101/2025.09.30.679470v1
October 2, 2025 at 4:17 AM
Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells https://www.biorxiv.org/content/10.1101/2025.09.30.679470v1
Reposted by Cole J. Batty
In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!
September 20, 2025 at 2:53 PM
In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!
Reposted by Cole J. Batty
Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too.
Plus it is dirt cheap. 🎤
Plus it is dirt cheap. 🎤
September 19, 2025 at 2:39 PM
Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too.
Plus it is dirt cheap. 🎤
Plus it is dirt cheap. 🎤
Reposted by Cole J. Batty
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition https://www.biorxiv.org/content/10.1101/2025.08.27.672737v1
September 1, 2025 at 3:16 PM
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition https://www.biorxiv.org/content/10.1101/2025.08.27.672737v1
Reposted by Cole J. Batty
Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 12, 2025 at 6:47 PM
Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Cole J. Batty
Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies https://www.biorxiv.org/content/10.1101/2025.07.04.663145v1
July 8, 2025 at 12:16 AM
Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies https://www.biorxiv.org/content/10.1101/2025.07.04.663145v1
Reposted by Cole J. Batty
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation
Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...
www.medrxiv.org
June 21, 2025 at 11:29 AM
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
Reposted by Cole J. Batty
Preprint: In vitro induction of human germinal center B-cells
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
June 4, 2025 at 2:09 AM
Preprint: In vitro induction of human germinal center B-cells
www.researchsquare.com/article/rs-6...
www.researchsquare.com/article/rs-6...
Reposted by Cole J. Batty
We are still recruiting a B-cell immunologist to join our team and lead projects funded by the Gates Foundation and NIH. If you are looking for a postdoc or a more senior Staff Scientist position, please apply!
Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!
Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!
We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
May 16, 2025 at 8:29 PM
We are still recruiting a B-cell immunologist to join our team and lead projects funded by the Gates Foundation and NIH. If you are looking for a postdoc or a more senior Staff Scientist position, please apply!
Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!
Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!
Don't sleep on LINE1s!
Can blocking “jumping genes” treat diseases and aging?
The first clinical trials are testing inhibitors of transposons, #DNA sequences that hop around the genome on their own. scim.ag/4cHvdC4
The first clinical trials are testing inhibitors of transposons, #DNA sequences that hop around the genome on their own. scim.ag/4cHvdC4
Could blocking ‘jumping genes’ help fight disease and aging?
The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own
scim.ag
April 18, 2025 at 1:57 PM
Don't sleep on LINE1s!
Rest in peace to inspiring scientist and mentor Michael Cancro www.cell.com/immunity/ful...
Michael Cancro (1949–2025)
Just a few weeks ago, researchers and educators connected to immunology lost a wonderful friend and colleague: Michael Cancro, professor of pathology and lab medicine at the University of Pennsylvania, passed away suddenly at his home just outside Philadelphia. He will be deeply missed.
www.cell.com
April 9, 2025 at 1:40 PM
Rest in peace to inspiring scientist and mentor Michael Cancro www.cell.com/immunity/ful...
Reposted by Cole J. Batty
We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
April 4, 2025 at 10:14 PM
We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).
ghosnlab.science/join-us
#BYourCell
Reposted by Cole J. Batty
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
April 2, 2025 at 3:43 AM
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Cool
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - @jaweinst.bsky.social @uchicagopme.bsky.social go.nature.com/42hJ1Q2
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - Nature Biotechnology
Volumetric DNA microscopy captures spatial information of RNA within an intact organism.
go.nature.com
March 27, 2025 at 3:49 PM
Cool
Reposted by Cole J. Batty
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses
encounter and establishing immunity at the initial point of path...
www.pnas.org
March 25, 2025 at 10:28 AM
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Reposted by Cole J. Batty
@labonnelab.bsky.social
overcast.fm/+AA5AWObyBF8
What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!
overcast.fm/+AA5AWObyBF8
What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!
Trump’s NIH Cuts Send Shockwaves Through the Science World — Odd Lots
overcast.fm
March 8, 2025 at 1:32 PM
@labonnelab.bsky.social
overcast.fm/+AA5AWObyBF8
What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!
overcast.fm/+AA5AWObyBF8
What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!
I'm happy to have played a small part in this first paper from an ongoing collaboration between the Marasco, Sage, Haigis, and Hemberg labs to decipher mechanisms of poor influenza vaccine response in older individuals
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
March 5, 2025 at 11:30 PM
I'm happy to have played a small part in this first paper from an ongoing collaboration between the Marasco, Sage, Haigis, and Hemberg labs to decipher mechanisms of poor influenza vaccine response in older individuals
Reposted by Cole J. Batty
Online now: Online now: Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later
Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later
To understand the influence and longevity of early influenza imprinting, Spangler et al. investigate the response to an H2 HA vaccine in individuals with and without exposure to H2N2 virus 50 years ago. They find that those with prior exposure have a…
dlvr.it
February 28, 2025 at 8:55 PM
Online now: Online now: Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later
Reposted by Cole J. Batty
The NIH funding freeze has blocked 3 of our grant proposals (so far), which threatens to shut down our Lyme disease research program within a year.
🦠🧫🧪🧬🔬 #MicroSky
www.reuters.com/business/hea...
🦠🧫🧪🧬🔬 #MicroSky
www.reuters.com/business/hea...
Trump administration loophole snags US research grants from Lyme to lung disease
The Trump administration has for weeks been blocking the U.S. National Institutes of Health process for issuing new research grants for everything from Lyme disease to lung and heart disease, according to researchers, a departing NIH official and documents.
www.reuters.com
February 27, 2025 at 12:38 AM
The NIH funding freeze has blocked 3 of our grant proposals (so far), which threatens to shut down our Lyme disease research program within a year.
🦠🧫🧪🧬🔬 #MicroSky
www.reuters.com/business/hea...
🦠🧫🧪🧬🔬 #MicroSky
www.reuters.com/business/hea...
Reposted by Cole J. Batty
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
February 21, 2025 at 3:19 PM
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)