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Dan Nomura @dannomura.bsky.social · 9d

Looking forward to seeing friends and giving a talk about our latest research at @stanfordchemistry.bsky.social @stanforduniversity.bsky.social tomorrow! chemistry.stanford.edu/events/chemi...

Chemical Biology Seminar: Professor Dan Nomura, University of California, Berkeley | Chemistry

About the Seminar "Reimagining Druggability using Chemoproteomic Platforms"The Nomura Research Group is focused on reimagining druggability using chemoproteomic platforms to develop transformative med...

chemistry.stanford.edu

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Dan Nomura @dannomura.bsky.social · Aug 4

We’re happy to highlight our newest
@biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...

Covalent Degraders of Immune Regulatory Transcription Factors IRF8 and IRF5

Transcription factors are among the most challenging targets for drug discovery due to their lack of classical binding pockets and high degree of intrinsic disorder, despite the therapeutic importance...

www.biorxiv.org

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Dan Nomura @dannomura.bsky.social · Jun 27

Haha I would never…

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Dan Nomura @dannomura.bsky.social · Jun 27

This paper now out in ACS Central Science!! pubs.acs.org/doi/10.1021/...

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Dan Nomura @dannomura.bsky.social · Jun 13

Awesome to be back in Cambridge for #ChemBiointhePub ahead of the Bioorganic Chemistry GRC!

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Dan Nomura @dannomura.bsky.social · Jun 10

Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...

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Reposted by Dan Nomura

Molecular Therapeutics Initiative @mti-ucb.bsky.social · Jun 8

Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen.
#MTI #Amgen #Biotech #UCB

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Reposted by Dan Nomura

Jordan Meier @doc-jlmeier.bsky.social · Jun 3

Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores).

Spirit: chembio-shop.fourthwall.com/products/grc...

World Tour: chembio-shop.fourthwall.com/products/spi...

Spirit

Preliminary score: ND

chembio-shop.fourthwall.com

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Reposted by Dan Nomura

James Olzmann @olzmannlab.bsky.social · May 29

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
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Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

www.pnas.org

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Dan Nomura @dannomura.bsky.social · May 19

Congrats to chem bio grad students Ellie King, Lauren Orr, and Vienna Thomas on graduating with their PhD's!

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Dan Nomura @dannomura.bsky.social · May 16

Our 2025 lab photo!

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Reposted by Dan Nomura

Alexander Hanzl @alexanderhanzl.bsky.social · May 8

- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.

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Reposted by Dan Nomura

Micha Rapé Lab @micharapelab.bsky.social · May 7

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

Molecular basis of SIFI activity in the integrated stress response - Nature

Nature - Molecular basis of SIFI activity in the integrated stress response

www.nature.com

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Dan Nomura @dannomura.bsky.social · May 6

www.statnews.com/2025/05/06/h...

How to stop the shift of drug discovery from the U.S. to China

U.S. pharmaceutical companies are increasingly licensing new drugs from China. Former FDA Commissioner Scott Gottlieb explains how to stop the shift.

www.statnews.com

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Reposted by Dan Nomura

Jordan Meier @doc-jlmeier.bsky.social · May 4

New-preprint alert! We use chemoproteomic profiling to show MYST KAT inhibitors exhibit hierarchical target engagement (KAT6A/B > KAT7 >> KAT8). Reminiscent of Type I kinase inhibitors, the selectivity of these small molecules varies based on concentration.

www.biorxiv.org/content/10.1...

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Dan Nomura @dannomura.bsky.social · Apr 26

Thanks to @olzmannlab.bsky.social for the great collaboration, and also thanks to @novartis.bsky.social @themarkfdn.bsky.social

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Dan Nomura @dannomura.bsky.social · Apr 26

Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.

www.biorxiv.org/content/10.1...

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...

www.biorxiv.org

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Reposted by Dan Nomura

Michael Erb @michael-erb.bsky.social · Apr 26

On my way to #aacr25. I’ll be chairing Part 3 of “Chemistry to the Clinic” tomorrow (4/26 at 2:30) with talks from @dannomura.bsky.social and @xiaoyuzhang.bsky.social. Weather report calls for lots of chemoproteomics, molecular glues, and tough targets. Please join us!

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Dan Nomura @dannomura.bsky.social · Apr 26

Excited to moderate a panel at the @theaacr.bsky.social CICR townhall at #2025AACR on "Charting the Course: Innovating Cancer Drug Discovery in a Challenging Landscape" alongside Shiva Malek, Gwenn Hansen, Ryan Schoenfeld, and Joseph Pearlberg!

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Dan Nomura @dannomura.bsky.social · Apr 26

Back in Chicago for #2025AACR! I’ll be giving a talk on our latest work tomorrow in the Educational Session on Advances in Ligand Discovery to Enable Previously Intractable Targets on Sat Apr 26th 2:30-4:00pm in S406 McCormick South alongside @michael-erb.bsky.social & @xiaoyuzhang.bsky.social !

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Dan Nomura @dannomura.bsky.social · Apr 25

Amazing talk yesterday by @rushika-perera.bsky.social for our Molecular Therapeutics seminar series!

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Dan Nomura @dannomura.bsky.social · Apr 3

Had such an awesome time at @themarkfdn.bsky.social symposium today!!

The Mark Foundation for Cancer Research @themarkfdn.bsky.social · Apr 3

Great afternoon of talks by @dannomura.bsky.social, Jeff Rathmell, Jun Wang, and Cathy Wu on reimagining druggability, the impact of obesity on immunotherapy response, antigen presentation inhibitors, & neoantigen discovery. That’s a wrap on #MarkSymposium 2025 – thanks for following along!