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Michael Erb @michael-erb.bsky.social · 10d

Does it protect against playoff losses? Go dodgers!

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Reposted by Michael Erb

Craig M. Crews @craigmcrews.bsky.social · Aug 2

www.biorxiv.org/content/10.1...

Rewiring DNA repair with PARP-based chemical inducers of proximity

Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...

www.biorxiv.org

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Michael Erb @michael-erb.bsky.social · Jul 31

One detail we are very excited about: the potential for PCIPs to selectively target tumors with acquired resistance to conventional PARP inhibitors. while KO of PARP1 is a major mechanism of resistance to PARPi, PARP1 knockout cells are actually more sensitive to PCIP-1. (3/3)

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Michael Erb @michael-erb.bsky.social · Jul 31

Thanks to @durocher1.bsky.social & all collaborators. Highlights: a generalizable strategy to discover new classes of CIPs, synthetic lethality with BRCA mutations, overcoming resistance to conventional PARP inhibitors, and proof-of-concept for rewiring DNA repair with proximity pharmacology. (2/3)

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Michael Erb @michael-erb.bsky.social · Jul 31

New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)

www.biorxiv.org/content/10.1...

Rewiring DNA repair with PARP-based chemical inducers of proximity

Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...

www.biorxiv.org

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Reposted by Michael Erb

Rita Strack @ritastrack.bsky.social · Jun 16

At the Bioorganic GRC. Ahmed Bedram just gave a very cool talk on genetic code expansion with quadruplet codons. Check out some of the work here www.nature.com/articles/s41...

Efficient genetic code expansion without host genome modifications - Nature Biotechnology

Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage.

www.nature.com

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Michael Erb @michael-erb.bsky.social · Jun 6

Yesterday’s game rocked

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Michael Erb @michael-erb.bsky.social · Apr 26

On my way to #aacr25. I’ll be chairing Part 3 of “Chemistry to the Clinic” tomorrow (4/26 at 2:30) with talks from @dannomura.bsky.social and @xiaoyuzhang.bsky.social. Weather report calls for lots of chemoproteomics, molecular glues, and tough targets. Please join us!

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Reposted by Michael Erb

Jordan Meier @doc-jlmeier.bsky.social · Apr 10

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

www.training.nih.gov

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Reposted by Michael Erb

Giordano Lippi @lippilab.bsky.social · Apr 2

Delighted to see our paper finally out in @cp-neuron.bsky.social! Together with Ian MacRae, we developed a new toolbox to study microRNAs and used it to find new mechanisms of Purkinje cell development. Please see the tweetorial from researcher extraordinaire @norjin.bsky.social for details.

Nori Zolboot @norjin.bsky.social · Apr 2

✨So happy to see part of my PhD work with @lippilab.bsky.social out today in @cp-neuron.bsky.social! ✨

We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:

MicroRNA mechanisms instructing Purkinje cell specification

Zolboot et al. introduce DD-T6B and SAP-seq, methods for investigating microRNA function with enhanced spatiotemporal resolution, and identify Purkinje cell-specific microRNAs and targets instructing ...

www.cell.com

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Reposted by Michael Erb

ACS BIOL: Division of Biochemistry and Chemical Biology @acsbiol.bsky.social · Mar 27

Congratulations to Prof. Brian Liau, recipient of this year's Eli Lilly Award in Biological Chemistry, and to the excellent presenters who made up this morning's award symposium!
@michael-erb.bsky.social, Jesus Gutierrez, @brianliau.bsky.social, Yuh Min Chook, @xiaoyuzhang.bsky.social
#ACSSpring2025

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Michael Erb @michael-erb.bsky.social · Mar 25

excited to celebrate Brian's Eli Lilly award tomorrow and to talk all things molecular glues!

Brian Liau @brianliau.bsky.social · Mar 25

Interested in small molecule mechanism? If you’re at #ACSSpring2025, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from @michael-erb.bsky.social, Yuh Min Chook & @xiaoyuzhang.bsky.social. I’ll discuss our program on chemical genomics. Come check it out!

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Reposted by Michael Erb

Chris Parker @chrisgparker.bsky.social · Mar 23

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social

www.biorxiv.org/content/10.1...

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

www.biorxiv.org

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Reposted by Michael Erb

Jordan Meier @doc-jlmeier.bsky.social · Mar 24

At his last celebration, he said something that stayed with me: "When you start, you think science is about the papers...then you realize it's about the people."

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Michael Erb @michael-erb.bsky.social · Mar 20

several of which bat at the top of the order in semester II of Chem Bio here at TSRI

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Reposted by Michael Erb

Georg Winter @georgwinter.bsky.social · Mar 13

Something that qualifies as big news from my side:
I am very happy and excited to announce that I have been appointed as Life Science Director at AITHYRA, a new Research Institute for Biomedical Artificial Intelligence.

Find out more in the link and 🧵 below

lnkd.in/d_HaGuSE

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Michael Erb @michael-erb.bsky.social · Mar 13

such exciting news! congrats georg!

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Reposted by Michael Erb

Jonathan Rosenblum @jsrosenblum.bsky.social · Feb 27

Make Thalidomide-for-morning-sickness Great Again

Pearl Freier @pearlf.bsky.social · Feb 27

Also included in the "Results Act" from Cruz and Roy—congress would be able to override the FDA's decision on a drug: "Grants Congress the authority to disapprove a denied application & override an FDA decision with a majority vote via a joint resolution." #medsky #biosky

Pearl Freier @pearlf.bsky.social · Feb 27

China's FDA agency approved a seaweed-based drug Oligomannate for Alzheimer's disease & dementia in '19. The below bill would allow drugs like that to be sold in the US: "reciprocal drug approval." This bill called "Results Act" would also support laying off >50% of the US's FDA #medsky #biosky

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Reposted by Michael Erb

ChemKritzer @chemkritzer.bsky.social · Feb 19

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.

If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

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Michael Erb @michael-erb.bsky.social · Feb 14

Time stamped right before the USA domination! 😂

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Michael Erb @michael-erb.bsky.social · Feb 13

Congrats Brian and team. Such an elegant discovery. Small molecules can do it all!

Brian Liau @brianliau.bsky.social · Feb 12

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

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Michael Erb @michael-erb.bsky.social · Feb 8

I get that. Obviously I, like Ryan, am at the type of institute that would be among the most severely affected. But I would still like to see good science to get good airtime.

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Michael Erb @michael-erb.bsky.social · Feb 8

I’m becoming quite good at magical thinking

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Michael Erb @michael-erb.bsky.social · Feb 8

check out this beautiful science from Xiaoyu, it'll cure your NIH blues for a few minutes

Dan Nomura @dannomura.bsky.social · Feb 8

Exciting paper from Xiaoyu Zhang's lab at Northwestern: pubs.acs.org/doi/full/10....

Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation

Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, expanding the repertoire of E3 ligases compatible with this approach could enhance the applicability of this strategy across various biological contexts. In this study, we discovered that a somatic mutant of FBXW7, R465C, can be exploited by heterobifunctional compounds for targeted protein degradation. This work demonstrates the potential of utilizing mutant E3 ligases that occur exclusively in diseased cells for TPD applications.

pubs.acs.org

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Reposted by Michael Erb

Vijay G. Sankaran @bloodgenes.bsky.social · Feb 8

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

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