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Reposted by Juan Carlos De la Concepcion

John Innes Centre @johninnescentre.bsky.social · 15h

Applications are now OPEN for the JIF Rotation PhD Programme

This prestigious 4-year #PhD programme trains graduate students in Plant and Microbial Sciences at the JIC, @thesainsburylab.bsky.social and @earlhaminst.bsky.social.

🗓️ Closing date - 13 November 2025

www.jic.ac.uk/training-car...

Rotation biology PhDs | John Innes Centre

Prestigious studentships, for entry in October 2022, this multi-disciplinary PhD programme includes; plant science, microbiology, biological chemistry, applied mathematics…

www.jic.ac.uk

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Chris H. Hill @chillzaa.bsky.social · 1d

Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...

Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES

Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...

www.biorxiv.org

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MPI for Biology Tübingen & Friedrich Miescher Laboratory @mpi-bio-fml.bsky.social · 3d

Come along this Friday for the next Distinguished Speaker Seminar Series talk to be delivered by Prof. Nick Talbot from The Sainsbury Laboratory, Norwich. Everyone is welcome!

▶️More info: tinyurl.com/xnanannn
📆: Friday 10th October at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS #MPI-IS

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John Innes Centre @johninnescentre.bsky.social · 5d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

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Roger Castells @rcastellsg.bsky.social · 3d

We’re looking for an enthusiastic postdoc to join our team. 😊

The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪

The position is fully funded for 3 years.

Please share 🙏

Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...

Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group

DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...

www.cnio.es

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Victor Tatarskiy @greenrat.bsky.social · 6d

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

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GeminiTeamLab @geminiteamlab.bsky.social · 5d

How do geminiviruses maximize their limited coding capacity? Our recent preprint uncovers splicing of viral transcripts as one more strategy used by this viral family. We show that RNA splicing is prevalent in the geminivirus TYLCV — and required for infectivity! www.biorxiv.org/content/10.1...

Pervasive splicing in a plant DNA virus

Viruses maximize their limited coding space through strategies that increase transcript and protein diversity. In mammalian viruses, splicing is a well-established mechanism for proteome expansion, ye...

www.biorxiv.org

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David Kuster @rnadavid.bsky.social · 4d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Edward T Eng @edwardteng.bsky.social · 4d

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

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Manlio De Domenico @manlius.bsky.social · 8d

Nearly 4,000 y ago, Egyptians finished their pyramids

Meanwhile, across the ocean, termites in NE Brazil were building something even larger: a hidden empire of 200M mounds, over an area the size of UK 🌍🐜

Still active today, a masterpiece of non-human engineering!
🧪🌐 HT @ricardsole.bsky.social

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Gabriel Mendoza-Rojas @gabmrojas.bsky.social · 9d

🧵How does a pathogen know it has entered its host?

New preprint!🎉It’s a pleasure to share my first first-author preprint from my PhD journey!
We uncover a novel co-evolved peptide–GPCR system in the fungus Ustilago maydis that senses host entry and triggers infection (doi.org/10.1101/2025...)
(1/5)

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11d

A co-evolved peptide-GPCR system senses host entry to drive fungal infection https://www.biorxiv.org/content/10.1101/2025.09.26.678928v1

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Alicia Michael @aliciakmichael.bsky.social · 8d

We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at

8th Austrian Cryo-EM Symposium

cryoem-symposium.pages.ist.ac.at

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Victor S @vmourade.bsky.social · 8d

New Preprint alert! It is finally here!
M incognita is a remarkable pathogen: extremely specialised with the widest host range (> 3,000). All this while reproducing parthenogenetically! We analyse the infection phenotype and transcriptome of 9 hosts (6 orders) at 25 dpi.
doi.org/10.1101/2025...

The host range paradox of Meloidogyne incognita: a physiological and transcriptomic analysis of nine susceptible interactions across six plant orders

The plant-parasitic nematode Meloidogyne incognita is the pathogen with the broadest host range among all known biotrophic interactions. This species is also the single most damaging of a group of agr...

www.biorxiv.org

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Margot Smit @likeyoda1.bsky.social · 8d

Check out our new review in JXB:
tinyurl.com/yta6fd5b

@pablidopsis.bsky.social and I write about the cell's decision between division and differentiation. 🌱 What factors promote one or the other in different cell types? 🤔 Are they really mutually exclusive?

Validate User

tinyurl.com

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Pablo González-Suárez @pablidopsis.bsky.social · 8d

Our new review just got published in JXB - together with
@likeyoda1.bsky.social
we discuss recent findings on mechanisms that cells use to 'decide' between dividing and differentiating in plants 🪴 tinyurl.com/yta6fd5b

Diagrams depicting the mitotic cell cycle and potential exits from it (left) and morphologies of different tissues of Arabidopsis thaliana: cotyledon, shoot apical meristem, leaf, sepal, inflorescence meristem, anther (right)

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Michael Hothorn @structplantbio.bsky.social · 8d

Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...

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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 9d

Congrats Helen!! 🎉

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Reposted by Juan Carlos De la Concepcion

Helen Brabham @helenbrabs.bsky.social · 9d

Super excited to see our work on the NLRseek program finally published 🥳 Here we identify new NLRs against major wheat pathogens and present a pipeline for NLR identification. Huge thank you to all of the co-authors for bringing this work together! @matthewmoscou.bsky.social rdcu.be/eIGvv

Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping

Nature Plants - Rapid discovery of functional resistance genes is enabled by a high-expression signature and high-throughput transformation. This approach identified 31 new resistance genes for...

rdcu.be

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Nadja M. Hümpfer @nadjahuempf.bsky.social · 10d

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11d

A co-evolved peptide-GPCR system senses host entry to drive fungal infection https://www.biorxiv.org/content/10.1101/2025.09.26.678928v1

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IMP @impvienna.bsky.social · 13d

🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT!

She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...

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georghochberg.bsky.social @georghochberg.bsky.social · 14d

A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...

Origin of chaperone dependence and assembly complexity in Rubisco biogenesis

Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...

www.biorxiv.org

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John Innes Centre @johninnescentre.bsky.social · 14d

Our researchers are looking into the past to protect UK wheat from a new fungal rust threat — searching for resistance genes in historic wheat lines to safeguard harvests and reduce the need for fungicide applications.

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Arnau Sebé-Pedrós @arnausebe.bsky.social · 14d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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Ulrich Hohmann @hohmannulrich.bsky.social · 16d

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

www.biorxiv.org

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