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Reposted by Roger Castells

Dimitrije @biodimi.bsky.social · 6d

Check out our latest work on the discovery and engineering of PiggyBac transposases! 🧵

Nature Biotechnology @natbiotech.nature.com · 6d

Discovery and protein language model-guided design of hyperactive transposases - @marcguellc.bsky.social @upf.edu @icreacommunity.bsky.social @crg.eu go.nature.com/4gXLGEw

Discovery and protein language model-guided design of hyperactive transposases - Nature Biotechnology

Phylogenetic mining and protein language models uncover improved PiggyBac transposase sequences.

go.nature.com

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Roger Castells @rcastellsg.bsky.social · 3d

We’re looking for an enthusiastic postdoc to join our team. 😊

The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪

The position is fully funded for 3 years.

Please share 🙏

Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...

Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group

DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...

www.cnio.es

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Reposted by Roger Castells

Gautam Dey @gautamdey.bsky.social · 4d

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.

I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

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Reposted by Roger Castells

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 6d

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions.

@aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social

www.nature.com/articles/s41...

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Roger Castells @rcastellsg.bsky.social · 11d

🤩🤩

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Roger Castells @rcastellsg.bsky.social · 11d

Happy anniversary!! :)

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Roger Castells @rcastellsg.bsky.social · 15d

Wow! So cool to see new mysterious protein complexes 🤩 so much to discover 🔬

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Reposted by Roger Castells

UCLA Department of Chemistry & Biochemistry @uclacb.bsky.social · 15d

🥳Congrats to Prof. David Eisenberg, who has been awarded the 2026 Gregori Aminoff Prize in Crystallography by the Royal Swedish Academy of Sciences! www.chemistry.ucla.edu/news/david-e...

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Roger Castells @rcastellsg.bsky.social · 25d

This is super cool and great investigative work! Thanks Oli and co! #smallparticles #cryoEM

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Reposted by Roger Castells

Craig Kaplan @triggerloop.bsky.social · Sep 3

Look at this crazy thing!
www.nature.com/articles/s41...

One mother for two species via obligate cross-species cloning in ants - Nature

In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

www.nature.com

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Roger Castells @rcastellsg.bsky.social · Aug 13

I love the symmetry of the library! 🤩

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Reposted by Roger Castells

Hank Green @hankgreen.bsky.social · Aug 3

Bugs on Flowers

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Reposted by Roger Castells

cniostopcancer.bsky.social @cniostopcancer.bsky.social · Jul 30

Verano de bachillerato en el laboratorio: Aitana Soler y Jan Magem viven la realidad de la investigación científica en #CNIOStopCancer con el programa ‘Jóvenes y ciencia’ de la Fundació Catalunya La Pedrera. Han trabajado un mes junto a @rcastellsg.bsky.social, que también participó en el programa

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Reposted by Roger Castells

Martin Pacesa @martinpacesa.bsky.social · Jul 25

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Reposted by Roger Castells

Julien Capin @ju-cap.bsky.social · Jul 17

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

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Reposted by Roger Castells

Sophien Kamoun @kamounlab.bsky.social · Jul 11

I just published: Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a citable record and protects you from bad actors.

#ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat

medium.com/p/why-im-ski...

Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…

medium.com

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Reposted by Roger Castells

Microsoft Research @msftresearch.bsky.social · Jul 10

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

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Reposted by Roger Castells

Dmitri Petrov @petrovadmitri.bsky.social · Jul 11

There is no better feeling than to see people in your lab succeed!

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Waggoner Lab @labwaggoner.bsky.social · Jul 10

In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex @cp-cellreports.bsky.social @rcastellsg.bsky.social
www.cell.com/cell-reports...

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Reposted by Roger Castells

Jason McLellan @mclellanlab.bsky.social · Jun 18

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

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Reposted by Roger Castells

Yasin Dagdas @plantophagy.bsky.social · Jul 3

My last day at the @gmivienna.bsky.social & @viennabiocenter.bsky.social. Here’s what I accumulated at my (office) 🚪 🧵 1/advice from my daughters

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Roger Castells @rcastellsg.bsky.social · Jun 29

Thanks a lot Mart! :)

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Roger Castells @rcastellsg.bsky.social · Jun 29

Muchas gracias JC! :)

Roger Castells @rcastellsg.bsky.social · Jun 29

Thanks a lot Charles! :)

Roger Castells @rcastellsg.bsky.social · Jun 28

Honored and grateful to receive the Hawk Biosystems Award from the Spanish Biophysical Society 🙏 Thank you very much for this recognition! :)

cniostopcancer.bsky.social @cniostopcancer.bsky.social · Jun 27

Roger Castells-Graells receives the Hawk Biosystems Award from the Spanish Biophysics Society, which acknowledges researchers under 33 years of age.

@rcastellsg.bsky.social leads the Biomolecular Design and Structural Nanomedicine Group at #CNIOstopcancer.

Roger Castells-Graells receives the Hawk Biosystems Award from the Spanish Society of Biophysics

The researcher Roger Castells-Graells, from the Spanish National Cancer Research Center (CNIO), has received the “Hawk Biosystems” award, issued by the Spanish Society of Biophysics (SBE) in the context of its XVIII International Congress. Castells-Graells recently joined the CNIO to lead the new Biomolecular Design and Structural Nanomedicine Group. They focus on designing protein nanoparticles […]

bit.ly

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