Mike DiCuccio
@dicuccio.bsky.social
My son is my clan leader. I am nobody.
Genomics. Medicine. Computational biology. Fly fishing. Photography.
Genomics. Medicine. Computational biology. Fly fishing. Photography.
Reposted by Mike DiCuccio
You may not know it, but over the years Santa Claus has had an interesting relationship with nuclear weapons.
During World War II—on a visit to the Clinton Engineer Works in Oak Ridge, Tennessee—his sack of toys was subjected to a thorough search before he was allowed to enter the secret city.
During World War II—on a visit to the Clinton Engineer Works in Oak Ridge, Tennessee—his sack of toys was subjected to a thorough search before he was allowed to enter the secret city.
December 24, 2025 at 3:28 PM
You may not know it, but over the years Santa Claus has had an interesting relationship with nuclear weapons.
During World War II—on a visit to the Clinton Engineer Works in Oak Ridge, Tennessee—his sack of toys was subjected to a thorough search before he was allowed to enter the secret city.
During World War II—on a visit to the Clinton Engineer Works in Oak Ridge, Tennessee—his sack of toys was subjected to a thorough search before he was allowed to enter the secret city.
Reposted by Mike DiCuccio
Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social,
@natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
@natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
What sets the mutation rate of a cell type in an animal species?
Germline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of l...
www.biorxiv.org
December 22, 2025 at 3:09 PM
Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social,
@natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
@natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n
Reposted by Mike DiCuccio
"Nearly 80 years later, the simplex method is still among the most widely used tools when a logistical or supply-chain decision needs to be made under complex constraints."
only half followed the description of the simplex method in here but super interesting anyways
www.wired.com/story/resear...
only half followed the description of the simplex method in here but super interesting anyways
www.wired.com/story/resear...
Research Reveals the Optimal Way to Optimize
The leading approach to the simplex method, a widely used technique for balancing complex logistical constraints, can’t get any better.
www.wired.com
December 21, 2025 at 12:12 PM
"Nearly 80 years later, the simplex method is still among the most widely used tools when a logistical or supply-chain decision needs to be made under complex constraints."
only half followed the description of the simplex method in here but super interesting anyways
www.wired.com/story/resear...
only half followed the description of the simplex method in here but super interesting anyways
www.wired.com/story/resear...
Reposted by Mike DiCuccio
I don’t think we as a society have thanked @papapishu.bsky.social for obtaining, ripping, and uploading a master copy of the essential Ricky Jay And His 52 Assistants, Jay’s 1997 HBO special and the best distillation of his one of a kind talent archive.org/details/rick...
Ricky Jay & His 52 Assistants [1996] - RF Rip : Free Download, Borrow, and Streaming : Internet Archive
NOTE: DO NOT DOWNLOAD THE COMPRESSED MP4 THAT ARCHIVE.ORG AUTO-GENERATES. This is an RF rip of Ricky Jay and His 52 Assistants, to date the greatest card...
archive.org
December 14, 2025 at 12:42 AM
I don’t think we as a society have thanked @papapishu.bsky.social for obtaining, ripping, and uploading a master copy of the essential Ricky Jay And His 52 Assistants, Jay’s 1997 HBO special and the best distillation of his one of a kind talent archive.org/details/rick...
Reposted by Mike DiCuccio
Steve isn’t here anymore, but he always posted this picture on Hanukkah so I thought we could carry on his tradition and remember him.
Happy Hanukkah to our friends who celebrate. Rachel Posner, a rabbi’s wife in Kiel, Germany, took this photograph in 1931 -- a potent reminder that fascism must be fought in every generation, even if it's wrapped in an American flag and a red hat.
December 14, 2025 at 11:45 PM
Steve isn’t here anymore, but he always posted this picture on Hanukkah so I thought we could carry on his tradition and remember him.
Reposted by Mike DiCuccio
Reposted by Mike DiCuccio
I’ve decided to start watching more Movies Everyone’s Supposed to Watch. I’ll leave all my honest (and probably embarrassing) reactions in this thread. Please send recommendations!
October 3, 2025 at 6:53 PM
I’ve decided to start watching more Movies Everyone’s Supposed to Watch. I’ll leave all my honest (and probably embarrassing) reactions in this thread. Please send recommendations!
Reposted by Mike DiCuccio
Importantly, this was how the weightless astronauts actually saw Earth that day, with the South Pole at the top, tilted toward the Sun. Most subsequent reproductions reoriented it based on how we assume our planet looks from space.
The photograph is now known as the Blue Marble shot.
The photograph is now known as the Blue Marble shot.
December 7, 2025 at 2:15 PM
Importantly, this was how the weightless astronauts actually saw Earth that day, with the South Pole at the top, tilted toward the Sun. Most subsequent reproductions reoriented it based on how we assume our planet looks from space.
The photograph is now known as the Blue Marble shot.
The photograph is now known as the Blue Marble shot.
Reposted by Mike DiCuccio
Eleven years ago, I wrote to Tom Stoppard to ask about this coup de théâtre from 1949. It took me down an unexpected rabbit hole - in memory of Stoppard, here's what I found.
November 30, 2025 at 1:38 PM
Eleven years ago, I wrote to Tom Stoppard to ask about this coup de théâtre from 1949. It took me down an unexpected rabbit hole - in memory of Stoppard, here's what I found.
Reposted by Mike DiCuccio
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
GitHub - alanrogers/popgen: A course on population genetics
A course on population genetics. Contribute to alanrogers/popgen development by creating an account on GitHub.
github.com
November 27, 2025 at 7:10 PM
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
Reposted by Mike DiCuccio
Reposted by Mike DiCuccio
I am grateful for @adamjkucharski.bsky.social. He takes such care to deconstruct a claim made by the director of National Institutes of Health on excess mortality during the pandemic. We need sober analyses more than ever right now, even amidst the madness.
kucharski.substack.com/p/excess-mor...
kucharski.substack.com/p/excess-mor...
Excess mortality or excessive assumptions?
How to make a popular metric tell any story you like
kucharski.substack.com
November 22, 2025 at 10:29 PM
I am grateful for @adamjkucharski.bsky.social. He takes such care to deconstruct a claim made by the director of National Institutes of Health on excess mortality during the pandemic. We need sober analyses more than ever right now, even amidst the madness.
kucharski.substack.com/p/excess-mor...
kucharski.substack.com/p/excess-mor...
Reposted by Mike DiCuccio
In Gettysburg, Pennsylvania, 162 years ago today, President Lincoln gave one of the most famous speeches in American history, extolling the sacrifices of the men who died in the battle there. There are five known manuscript copies of the Gettysburg Address. The Library of Congress has two of those.
November 19, 2025 at 5:03 PM
In Gettysburg, Pennsylvania, 162 years ago today, President Lincoln gave one of the most famous speeches in American history, extolling the sacrifices of the men who died in the battle there. There are five known manuscript copies of the Gettysburg Address. The Library of Congress has two of those.
Reposted by Mike DiCuccio
wake up babe, new units of measurement just dropped www.nytimes.com/2025/11/17/s...
November 17, 2025 at 4:26 PM
wake up babe, new units of measurement just dropped www.nytimes.com/2025/11/17/s...
Reposted by Mike DiCuccio
65 Years Ago,,, History was made. #RubyBridges
November 15, 2025 at 4:41 AM
65 Years Ago,,, History was made. #RubyBridges
Reposted by Mike DiCuccio
Fall is here and many of you may be shopping for an overcoat.
Let me show what you can get as you move up the price ladder. 🧵
Let me show what you can get as you move up the price ladder. 🧵
Here are four overcoats.
— Which do you think is the most expensive?
— Which do you think is the least expensive?
— Which do you think provides the best value?
Answer below. Tomorrow, I will show what you get as you climb up the price ladder for overcoats.
— Which do you think is the most expensive?
— Which do you think is the least expensive?
— Which do you think provides the best value?
Answer below. Tomorrow, I will show what you get as you climb up the price ladder for overcoats.
November 7, 2025 at 9:09 PM
Fall is here and many of you may be shopping for an overcoat.
Let me show what you can get as you move up the price ladder. 🧵
Let me show what you can get as you move up the price ladder. 🧵
Reposted by Mike DiCuccio
HAPPY FOUR SEASONS TOTAL LANDSCAPING DAY TO ALL WHO CELEBRATE
November 7, 2025 at 6:44 PM
HAPPY FOUR SEASONS TOTAL LANDSCAPING DAY TO ALL WHO CELEBRATE
Reposted by Mike DiCuccio
So pleased to see the mRNA platform being used to develop new vaccines against tuberculosis!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 10:08 PM
So pleased to see the mRNA platform being used to develop new vaccines against tuberculosis!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mike DiCuccio
Good morning.
I don't know who did this, but I love you.
I don't know who did this, but I love you.
November 3, 2025 at 3:01 PM
Good morning.
I don't know who did this, but I love you.
I don't know who did this, but I love you.
Reposted by Mike DiCuccio
Stack of Jacquard loom cards, about two meters in length at Queen’s Street Mill, near Burnley
By my calculation about 120kb of data
By my calculation about 120kb of data
November 1, 2025 at 3:46 PM
Stack of Jacquard loom cards, about two meters in length at Queen’s Street Mill, near Burnley
By my calculation about 120kb of data
By my calculation about 120kb of data
Reposted by Mike DiCuccio
Reposted by Mike DiCuccio
This is just to say
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
There was an old man you could gaze
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
October 30, 2025 at 12:53 AM
This is just to say
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
I have looked on
the works
that were in
the desert
and which
you were probably
thinking
would still stand
Forgive me
they were trunkless
so vast
and so old
Reposted by Mike DiCuccio
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
There was an old man you could gaze
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
At his works in despair in a daze
If you looked upon them
And were mere mortal men
'Ozymandias mighty', it says
My name is Pagliacci, Clown of Clowns. Look on my works, ye doctors; I despair.
October 30, 2025 at 12:41 AM
Once upon a desert sandy
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
As through winds the trav'ling man he
Spied the face of Ozymandy
Lying, simply lying there
Suddenly there was some writing
Pon the plinth that he was sighting
That the sand and time were blighting
Quoth the statue, "Now despair"
Reposted by Mike DiCuccio
COOLEST RUNNINGS,,, cuz it’s Cooler than Cool Runnings.
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
October 27, 2025 at 4:54 PM
COOLEST RUNNINGS,,, cuz it’s Cooler than Cool Runnings.
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Your boy Flavor Flav is now an Official Sponsor and The Official Hype Man of the USA Olympic Bobsled + Skeleton team. YEAH BOOYYYEEEE,!!
Reposted by Mike DiCuccio
Random math fact: the golden ratio (1.618) is very close to the conversion ratio from miles to kilometers (1.609), meaning you can use the Fibonacci sequence to convert between miles and km: 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, 144, 233, 377, 610, 987, 1597, etc.
October 25, 2025 at 12:11 PM
Random math fact: the golden ratio (1.618) is very close to the conversion ratio from miles to kilometers (1.609), meaning you can use the Fibonacci sequence to convert between miles and km: 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, 144, 233, 377, 610, 987, 1597, etc.