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Effie Apostolou lab @efapostolou29.bsky.social · 5d

Congratulations Christa!!! Wishing you many productive and fun lab decades ahead! That seems delicious!!!

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Effie Apostolou lab @efapostolou29.bsky.social · 9d

👇👇👇

Dafne Campigli Di Giammartino @dafnecdg.bsky.social · 9d

🚨For chromatin, epigenetics and non-coding RNA lovers: only two more weeks left to apply!

Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it

Research Technician
app.ncoreplat.com/jobposition/...

Senior Researcher-Technologist
app.ncoreplat.com/jobposition/...

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Effie Apostolou lab @efapostolou29.bsky.social · 22d

Honored and excited to be among the speakers in the upcoming #KSEpigenetics26 symposium! Thank you @kjarmache.bsky.social and @ckadoch.bsky.social for the invitation. Follow the link to register 👇👇👇

Karim-Jean Armache @kjarmache.bsky.social · 22d

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia

Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

keysym.us

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Reposted by Effie Apostolou lab

Eric Topol @erictopol.bsky.social · Sep 7

Fraud, using A.I., impersonating medical professionals
Front page NY Times
www.nytimes.com/2025/09/05/t...

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Reposted by Effie Apostolou lab

Benoit Bruneau @benoitbruneau.bsky.social · Sep 5

This is amazing: www.theatlantic.com/newsletters/...

Florida Decided There Were Too Many Children

The state’s elimination of vaccine mandates is a courageous first step toward decluttering itself of any excess kids.

www.theatlantic.com

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Effie Apostolou lab @efapostolou29.bsky.social · Aug 26

Honored to be part of the "Reprogramming Stars" interview series by @cellreprolab.bsky.social @CellularReprogramming. Humbling title but very fun discussion about past and ongoing research, future directions, advice to new trainees and more. Check it out! www.liebertpub.com/doi/10.1177/...

Reprogramming Stars #23: Charting Cell Fate Crossroads from the Interplay Between Epigenetics, Transcription, and 3D Chromatin Architecture—An Interview with Dr. Effie Apostolou | Cellular Reprogrammi...

Cellular Reprogramming

www.liebertpub.com

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Effie Apostolou lab @efapostolou29.bsky.social · Aug 12

Another Exciting Fusion conference on 3D genome organization is coming up! #SGO25! Deadline for registration on September 1st! Hope to see many of you there!

Fusion Conferences @fusionconf.bsky.social · Aug 7

@efapostolou29.bsky.social we are looking forward to your presentation at the #SGO25 ! Please share this with your followers to let them know the poster and registration deadline is fast approaching - Monday 01 September!
Register now ➡️https://bit.ly/4lhu1YX

Reposted by Effie Apostolou lab

Liz Essley Whyte @lizessleywhyte.bsky.social · Jul 29

NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year

Chokes off billions in research funding

Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

Trump Administration Puts New Chokehold on Billions in Health-Research Funding

The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

www.wsj.com

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Effie Apostolou lab @efapostolou29.bsky.social · Jul 30

WTF??? www.statnews.com/2025/07/29/t...

Trump administration blocks NIH from awarding any research grants and contracts

The order applies to the entirety of new and, possibly, ongoing research grant dollars that go to universities and academic medical centers.

www.statnews.com

Reposted by Effie Apostolou lab

Stand Up for Science! @standupforscience.bsky.social · Jun 29

The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.

Thousands of lives at risk for tax cuts for the rich? NO THANKS.

Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX

zurl.co/RCR0y
#CutsCostLives

Will the Senate Save NIH?

Rescuing biomedical research is every bit as important as saving Medicaid.

zurl.co

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Reposted by Effie Apostolou lab

brumbaugh-lab.bsky.social @brumbaugh-lab.bsky.social · May 13

Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.

Bruno Di Stefano @distefanolab.bsky.social · May 12

New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Recent studies have emphasized the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of RNA condens...

www.biorxiv.org

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Reposted by Effie Apostolou lab

Todd Macfarlan @toddmacfarlan.bsky.social · Apr 29

I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...

www.training.nih.gov

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Reposted by Effie Apostolou lab

Anja Groth @groth-anja.bsky.social · Mar 28

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

That’s huge!!! Congratulations Bing and welcome to NYC!!!

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

Special thanks to the @themarkfdn.bsky.social for believing and supporting this project from the very beginning and to NIH for their funding! #3DGenome #Glioblastoma

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

Congratulations to @SarahBreves, @dafnecdg.bsky.social and Alex Polyzos for driving this study and many thanks to the Fine group and all collaborators for their critical contributions!!! Grateful also to Howard Chang for sharing their data.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

What drives 3D hub formation? Intriguingly, only a small fraction of 3D hubs overlapped with predicted structural variants, such as amplifications, suggesting epigenetic mechanisms. Transcription factors with enriched binding on hubs were often predictive of worse outcomes.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

What about other cancers? Using published HiChIP datasets across 16 cancer types we also identified shared and tumor-specific 3D hubs associated with universal or cancer-specific oncogenic programs.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

CRISPRi targeting of a highly recurrent hub -with previously unknown role in GBM- was sufficient to cause concordant downregulation of multiple hub-connected genes, global transcriptional shifts and reduced clonogenicity.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

Moreover, gene pairs within hubs showed significantly higher coregulation in single-cells compared to genes within the same TAD or in proximity. However, for hubs connected to multiple genes the mean coregulation is highly variable likely reflecting intratumoral heterogeneity.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

By mapping 3D enhancer-promoter networks in patient-derived glioblastoma stem cells, we identified hyperconnected 3D hubs that strongly enriched for universal and tumor-specific programs and accurately distinguished aggressive IDH-wt from lower-grade glioma patients.

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 27

The first cancer-related story from our group @WeillCornell
is now published in @MolecularCell. We investigate the role of hyperconnected 3D regulatory hubs in controlling oncogenic programs and properties in glioblastoma and also across 16 cancer types. www.cell.com/molecular-ce...

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

Here, Breves et al. profile the 3D enhancer-promoter connectomes of patient-derived glioblastoma stem cells (GSCs), identify hyperconnected 3D regulatory “hubs” relevant for GBM biology, examine the i...

www.cell.com

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 26

Certainly very intriguing model @stefanschoenfelder.bsky.social and consistent with many puzzling observations upon cohesin loss. Potentially also explaining why the transcriptional impact is stronger upon differentiation as “mixing” might be needed to enable new enhancer-promoter interactions.

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Reposted by Effie Apostolou lab

Mikhail Spivakov @mspivakov.bsky.social · Mar 20

Postdoc position #1 is live! Please apply / spread the word!

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences

Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

lms.mrc.ac.uk

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Effie Apostolou lab @efapostolou29.bsky.social · Mar 21

It’s crazy how receiving an automated -previously routine- email that my grant application is scheduled for review this summer brought smile to my face! It can still be trashed but at least it would be after peer-review!!! #PIlife #GirlsJustWanttoHaveFUNding #StandforNIH

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