Maple the Maine Coon
@ergonod.bsky.social
Reposted by Maple the Maine Coon
Super cool.
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism
Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...
cancerandmetabolism.biomedcentral.com
May 20, 2025 at 11:07 AM
Super cool.
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
Reposted by Maple the Maine Coon
The Federal government is defaulting on its legally obligated debts. And anyone wonders why the US credit rating is going down?
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
May 19, 2025 at 11:34 AM
The Federal government is defaulting on its legally obligated debts. And anyone wonders why the US credit rating is going down?
Reposted by Maple the Maine Coon
No adorable infants involved in my work, but I am really proud of what I've done so far and am excited for Dr. Xiao Wang's talk today at 1:30PM central at #ASGCT2025! I started our lab's work on PXE from the ground-up and have learned so much along the way.
May 16, 2025 at 2:51 PM
No adorable infants involved in my work, but I am really proud of what I've done so far and am excited for Dr. Xiao Wang's talk today at 1:30PM central at #ASGCT2025! I started our lab's work on PXE from the ground-up and have learned so much along the way.
Reposted by Maple the Maine Coon
NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion #NeuroDegeneration
NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.05.05.652246v1
https://www.biorxiv.org/content/10.1101/2025.05.05.652246v1
May 10, 2025 at 10:12 AM
NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion #NeuroDegeneration
Reposted by Maple the Maine Coon
Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
May 6, 2025 at 12:52 PM
Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics
#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Reposted by Maple the Maine Coon
Reposted by Maple the Maine Coon
This is an excellent and thoughtful resource for people beginning to explore data visualization in R:
📊 📈 🔬✨
www.data-to-viz.com
#dataviz #datavis #R
📊 📈 🔬✨
www.data-to-viz.com
#dataviz #datavis #R
From data to Viz | Find the graphic you need
A classification of chart types based on their input data format.
www.data-to-viz.com
May 4, 2025 at 3:28 PM
This is an excellent and thoughtful resource for people beginning to explore data visualization in R:
📊 📈 🔬✨
www.data-to-viz.com
#dataviz #datavis #R
📊 📈 🔬✨
www.data-to-viz.com
#dataviz #datavis #R
For folks looking for faculty positions. There are three openings at the Dept of Pharm, Toxi and Neuroscience of LSUHS where I am moving to as the chair of the dept
jobs.sciencecareers.org/job/672153/p...
jobs.sciencecareers.org/job/672153/p...
Physician or PhD – MB Pharmacology and Toxicology – Full Time Academic - Shreveport, Louisiana job with Ochsner LSU Health | 672153
The Department of Pharmacology, Toxicology & Neuroscience at LSU Health Shreveport invites applications for a full-time, tenure-track faculty posit...
jobs.sciencecareers.org
May 3, 2025 at 12:02 AM
Reposted by Maple the Maine Coon
For folks looking for faculty positions. There are three openings at the Dept of Pharm, Toxi and Neuroscience of LSUHS where I am moving to as the chair of the dept
jobs.sciencecareers.org/job/672153/p...
jobs.sciencecareers.org/job/672153/p...
Physician or PhD – MB Pharmacology and Toxicology – Full Time Academic - Shreveport, Louisiana job with Ochsner LSU Health | 672153
The Department of Pharmacology, Toxicology & Neuroscience at LSU Health Shreveport invites applications for a full-time, tenure-track faculty posit...
jobs.sciencecareers.org
May 2, 2025 at 11:35 PM
For folks looking for faculty positions. There are three openings at the Dept of Pharm, Toxi and Neuroscience of LSUHS where I am moving to as the chair of the dept
jobs.sciencecareers.org/job/672153/p...
jobs.sciencecareers.org/job/672153/p...
Reposted by Maple the Maine Coon
Can I have some privacy please? I’m doing yoga #WhiskersWednesday #ItsACatsLife #GingerCats #CatsAreFamily #Cats #CatWorldDomination
April 30, 2025 at 5:57 AM
Can I have some privacy please? I’m doing yoga #WhiskersWednesday #ItsACatsLife #GingerCats #CatsAreFamily #Cats #CatWorldDomination
Reposted by Maple the Maine Coon
Clinically relevant clot resolution via a thromboinflammation-on-a-chip @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clinically relevant clot resolution via a thromboinflammation-on-a-chip - Nature
In thromboinflammation, early tissue plasminogen activator administration directly improves endothelial barrier function, prophylactic defibrotide and enoxaparin suppress microvascular thromboinflamma...
www.nature.com
April 3, 2025 at 12:13 AM
Clinically relevant clot resolution via a thromboinflammation-on-a-chip @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maple the Maine Coon
SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging
ATF3 physically sequestrates MDM2 (E3 ligase for p21)
ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs
#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...
ATF3 physically sequestrates MDM2 (E3 ligase for p21)
ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs
#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2025 at 8:06 PM
SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging
ATF3 physically sequestrates MDM2 (E3 ligase for p21)
ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs
#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...
ATF3 physically sequestrates MDM2 (E3 ligase for p21)
ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs
#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...
Rebuild a (tentacle of) Cthulhu
SpiRobs: Logarithmic spiral-shaped robots for versatile grasping across scales
3D printing
Grasping objecting (ant, USB cable, egg, bucket, cardbox) from mm to ~0.5 m
Mountable on robotic arm or drone
6-arm array
#Device 2024
www.sciencedirect.com/science/arti...
SpiRobs: Logarithmic spiral-shaped robots for versatile grasping across scales
3D printing
Grasping objecting (ant, USB cable, egg, bucket, cardbox) from mm to ~0.5 m
Mountable on robotic arm or drone
6-arm array
#Device 2024
www.sciencedirect.com/science/arti...
SpiRobs: Logarithmic spiral-shaped robots for versatile grasping across scales
Despite differences in structure and living environment, several animal appendages (e.g., octopus arms, elephant trunks, etc.) follow a common pattern…
www.sciencedirect.com
January 17, 2025 at 3:51 AM
Reposted by Maple the Maine Coon
