Micha Sam Brickman Raredon
@msbr89.bsky.social
Scientist/Engineer. Assistant Professor of Anesthesiology @ Yale. Tissue Biology, Lung Regeneration, Data Visualization. Here to learn. https://RaredonLab.com
Pinned
Reposted by Micha Sam Brickman Raredon
No cap hadley.github.io/genzplyr/
dplyr but make it bussin fr fr no cap
`genzplyr` is an alternative syntax for `dplyr` that replaces boring old function names with GenZ slang. Your data wrangling is about to hit different.
hadley.github.io
November 7, 2025 at 1:49 AM
No cap hadley.github.io/genzplyr/
Reposted by Micha Sam Brickman Raredon
Now reading:
"From this atlas, we found that the neuron composition of the developing and regenerating spinal cord differ. So do the strategies employed, which favor waves of cell-type specific neuron morphogenesis, proliferation, .." #devbio 🧪
And they found some frog Rohon-Beard neurons!
"From this atlas, we found that the neuron composition of the developing and regenerating spinal cord differ. So do the strategies employed, which favor waves of cell-type specific neuron morphogenesis, proliferation, .." #devbio 🧪
And they found some frog Rohon-Beard neurons!
January 20, 2026 at 1:31 PM
Now reading:
"From this atlas, we found that the neuron composition of the developing and regenerating spinal cord differ. So do the strategies employed, which favor waves of cell-type specific neuron morphogenesis, proliferation, .." #devbio 🧪
And they found some frog Rohon-Beard neurons!
"From this atlas, we found that the neuron composition of the developing and regenerating spinal cord differ. So do the strategies employed, which favor waves of cell-type specific neuron morphogenesis, proliferation, .." #devbio 🧪
And they found some frog Rohon-Beard neurons!
Reposted by Micha Sam Brickman Raredon
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
A competition model of multilineage priming and cell-fate decisions
In development, cells navigate highly complex gene-regulatory landscapes to make fate
choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity,
and collective multi...
www.cell.com
January 19, 2026 at 11:05 PM
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
Reposted by Micha Sam Brickman Raredon
#Frogpower here
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 6:14 PM
#Frogpower here
Reposted by Micha Sam Brickman Raredon
Córy Doctorow with another verbal bullseye: pluralistic.net/2026/01/13/n...
January 18, 2026 at 5:29 PM
Córy Doctorow with another verbal bullseye: pluralistic.net/2026/01/13/n...
Reposted by Micha Sam Brickman Raredon
Very good piece by @mashagessen.bsky.social, the author of Surviving Autocracy, who left Russia in 2013 as the authoritarian hammer really started coming down, and moved to the United States. Gift link: www.nytimes.com/2026/01/18/o...
January 19, 2026 at 3:43 AM
Very good piece by @mashagessen.bsky.social, the author of Surviving Autocracy, who left Russia in 2013 as the authoritarian hammer really started coming down, and moved to the United States. Gift link: www.nytimes.com/2026/01/18/o...
Reposted by Micha Sam Brickman Raredon
Lrat-Cre has long been used to mark Hepatic Stellate Cell
Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)🔥
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)🔥
bioRxiv 2026
www.biorxiv.org/content/10.6...
Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)🔥
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)🔥
bioRxiv 2026
www.biorxiv.org/content/10.6...
January 17, 2026 at 1:47 PM
Lrat-Cre has long been used to mark Hepatic Stellate Cell
Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)🔥
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)🔥
bioRxiv 2026
www.biorxiv.org/content/10.6...
Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)🔥
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)🔥
bioRxiv 2026
www.biorxiv.org/content/10.6...
🔥🔥👇🏼
scientific community is trained in reading papers presented as defense of preset conclusions (or hypotheses to the same effect) and struggles to react meaningfully to exploratory research written in an exploratory way. "what if this is a thing? let's see. huh turns out it isn't!" baffles reviewers.
January 17, 2026 at 7:54 PM
🔥🔥👇🏼
Reposted by Micha Sam Brickman Raredon
scientific community is trained in reading papers presented as defense of preset conclusions (or hypotheses to the same effect) and struggles to react meaningfully to exploratory research written in an exploratory way. "what if this is a thing? let's see. huh turns out it isn't!" baffles reviewers.
January 17, 2026 at 7:35 PM
scientific community is trained in reading papers presented as defense of preset conclusions (or hypotheses to the same effect) and struggles to react meaningfully to exploratory research written in an exploratory way. "what if this is a thing? let's see. huh turns out it isn't!" baffles reviewers.
Reposted by Micha Sam Brickman Raredon
So cool - someone finally hacked 'the vault'.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 16, 2026 at 1:10 PM
So cool - someone finally hacked 'the vault'.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Micha Sam Brickman Raredon
The 0.5.0 version of my {brms} + {tidyverse} translation of McElreath's "Statistical Rethinking" (2nd ed) is up!
solomon.quarto.pub/sr2/
1/3
#rstats
solomon.quarto.pub/sr2/
1/3
#rstats
Statistical rethinking 2 with rstan and the tidyverse
solomon.quarto.pub
January 14, 2026 at 3:08 PM
The 0.5.0 version of my {brms} + {tidyverse} translation of McElreath's "Statistical Rethinking" (2nd ed) is up!
solomon.quarto.pub/sr2/
1/3
#rstats
solomon.quarto.pub/sr2/
1/3
#rstats
Reposted by Micha Sam Brickman Raredon
Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026.
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de
January 14, 2026 at 2:19 PM
Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026.
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de
Reposted by Micha Sam Brickman Raredon
My "Friends don't let friends make bad graphs" repo is approaching 7k stars on GitHub. As of this moment, 6962, to be exact. 38 more to go to 7000.
github.com/cxli233/Frie...
github.com/cxli233/Frie...
January 13, 2026 at 12:56 PM
My "Friends don't let friends make bad graphs" repo is approaching 7k stars on GitHub. As of this moment, 6962, to be exact. 38 more to go to 7000.
github.com/cxli233/Frie...
github.com/cxli233/Frie...
Reposted by Micha Sam Brickman Raredon
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
January 13, 2026 at 8:27 AM
We've got ISSUES. Literally.
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
Reposted by Micha Sam Brickman Raredon
Today at 34 & Park in Minneapolis, a woman tried to drive down the street where a protest had broken out in front of a home ICE was raiding, saying she had a doctor apt to get to. ICE agents busted out her windows, cut off her seatbelt, and pulled her out before arresting her.
January 13, 2026 at 6:56 PM
Today at 34 & Park in Minneapolis, a woman tried to drive down the street where a protest had broken out in front of a home ICE was raiding, saying she had a doctor apt to get to. ICE agents busted out her windows, cut off her seatbelt, and pulled her out before arresting her.
Reposted by Micha Sam Brickman Raredon
Offering a high-resolution spatial atlas of pediatric arthritis:
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
January 13, 2026 at 2:03 PM
Offering a high-resolution spatial atlas of pediatric arthritis:
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
@juninamo.bsky.social & team profiles nearly 400,000 cells across 9 patients with juvenile idiopathic arthritis, revealing disease-specific immune–stromal interactions within the synovium: doi.org/10.1172/jci....
Reposted by Micha Sam Brickman Raredon
I've seen some cool gesture-based point cloud controllers.
So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️
Try it out: jef.works/GestureGraph/
So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️
Try it out: jef.works/GestureGraph/
January 13, 2026 at 3:10 PM
I've seen some cool gesture-based point cloud controllers.
So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️
Try it out: jef.works/GestureGraph/
So I noted the JS libraries used and vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via 🖐️
Try it out: jef.works/GestureGraph/
Reposted by Micha Sam Brickman Raredon
Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...
January 12, 2026 at 2:33 PM
Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...
Reposted by Micha Sam Brickman Raredon
I also wanted to document the pandemic experience. It sometimes feels like there's a collective amnesia about the period. It was a stress test for preprints, but also gave us a unique window into the incredible biomedical efforts to combat the virus and how the world was being impacted 3/n
January 12, 2026 at 2:42 PM
I also wanted to document the pandemic experience. It sometimes feels like there's a collective amnesia about the period. It was a stress test for preprints, but also gave us a unique window into the incredible biomedical efforts to combat the virus and how the world was being impacted 3/n
Reposted by Micha Sam Brickman Raredon
“When a person does well on the LSAT, you can also infer things about their ability to persevere at difficult work, or to manage stress. When a large language model does well on the LSAT, you can infer only that it can do well on the LSAT. This is a particular problem for higher education”
I, chatbot
Student use of AI is ubiquitous, disruptive, and irreversible. Now what?
www.yalealumnimagazine.com
January 11, 2026 at 3:45 PM
“When a person does well on the LSAT, you can also infer things about their ability to persevere at difficult work, or to manage stress. When a large language model does well on the LSAT, you can infer only that it can do well on the LSAT. This is a particular problem for higher education”
Reposted by Micha Sam Brickman Raredon
This is stunning. Listen to this in Philadelphia.
Thousands singing “Hey-Oh, we won’t be silent while our friends are gunned down.”
Really listen to it.
Thousands singing “Hey-Oh, we won’t be silent while our friends are gunned down.”
Really listen to it.
January 11, 2026 at 4:55 AM
This is stunning. Listen to this in Philadelphia.
Thousands singing “Hey-Oh, we won’t be silent while our friends are gunned down.”
Really listen to it.
Thousands singing “Hey-Oh, we won’t be silent while our friends are gunned down.”
Really listen to it.
Reposted by Micha Sam Brickman Raredon
Stack: In-Context Learning of Single-Cell Biology www.biorxiv.org/content/10.6... 🧬🖥️🧪
January 11, 2026 at 5:00 PM
Stack: In-Context Learning of Single-Cell Biology www.biorxiv.org/content/10.6... 🧬🖥️🧪
Reposted by Micha Sam Brickman Raredon
"It wasn't murder, and if you say it was murder we will kill you, which again will not be murder."
Homan: "We gotta stop the hateful rhetoric. Saying this officer is a murderer is dangerous. It's just ridiculous. It's gonna infuriate people more which means there's gonna be more incidents like this."
January 11, 2026 at 5:04 PM
"It wasn't murder, and if you say it was murder we will kill you, which again will not be murder."
Reposted by Micha Sam Brickman Raredon
“The system of funding science is fundamentally broken. In some respects, it’s been an unmitigated disaster. It was a house of cards, and it’s not surprising that it’s now falling apart.”
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
What’s Wrong with NIH Grants?
“Science is fundamentally different than remodeling a kitchen”
www.statecraft.pub
January 10, 2026 at 1:44 AM
“The system of funding science is fundamentally broken. In some respects, it’s been an unmitigated disaster. It was a house of cards, and it’s not surprising that it’s now falling apart.”
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
Reposted by Micha Sam Brickman Raredon
This is an extraordinary interview. I agree with almost everything Mike says here, and I couldn’t make a better argument for why our system for funding science needs an overhaul.
January 10, 2026 at 1:48 AM
This is an extraordinary interview. I agree with almost everything Mike says here, and I couldn’t make a better argument for why our system for funding science needs an overhaul.