@guobl.bsky.social
Reposted
You called? Check out Box 1 in this paper: journals.sagepub.com/doi/10.1177/...
December 29, 2025 at 11:36 AM
You called? Check out Box 1 in this paper: journals.sagepub.com/doi/10.1177/...
Reposted
This week saw the publication of SPIRIT 2025, a major update to the international SPIRIT Statement which provides guidance on what should be included in a trial protocol. 1/6
#MethodologyMonday #117
#MethodologyMonday #117
May 5, 2025 at 6:28 AM
This week saw the publication of SPIRIT 2025, a major update to the international SPIRIT Statement which provides guidance on what should be included in a trial protocol. 1/6
#MethodologyMonday #117
#MethodologyMonday #117
Reposted
Each of them a golden nugget on the appropriate use of stats …
#OTD 1994 the first of BMJ’s ‘Statistics Notes’ series (‘Correlation, regression and repeated data’) was published: “perhaps the finest series of short articles on the use of statistics.”. In 1993 BMJ asked Doug Altman to write a few 600-word “filler” pieces on statistics education. 1/2
April 3, 2025 at 1:42 PM
Each of them a golden nugget on the appropriate use of stats …
Reposted
New @nejm.org #ACC25
The global impact of 5 cardiovascular risk factors (BP, cholesterol, obesity, diabetes, smoking) on life expectancy in men and women
www.nejm.org/doi/full/10.1056/NEJMoa2415879
The global impact of 5 cardiovascular risk factors (BP, cholesterol, obesity, diabetes, smoking) on life expectancy in men and women
www.nejm.org/doi/full/10.1056/NEJMoa2415879
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates | NEJM
Five risk factors account for approximately 50% of the global burden of cardiovascular
disease. How the presence or absence of classic risk factors affects lifetime estimates
of cardiovascular dise...
www.nejm.org
March 30, 2025 at 10:00 PM
New @nejm.org #ACC25
The global impact of 5 cardiovascular risk factors (BP, cholesterol, obesity, diabetes, smoking) on life expectancy in men and women
www.nejm.org/doi/full/10.1056/NEJMoa2415879
The global impact of 5 cardiovascular risk factors (BP, cholesterol, obesity, diabetes, smoking) on life expectancy in men and women
www.nejm.org/doi/full/10.1056/NEJMoa2415879
Reposted
How avoidance of research waste is now emphasized in the Declaration of Helsinki, and how you might want to improve some of your data management and analysis practices in light of this change (talk, 40 minutes).
www.youtube.com/watch?v=q1nb...
www.youtube.com/watch?v=q1nb...
The Declaration of Helsinki now says you should avoid research waste. Here's how.
YouTube video by Darren Dahly
www.youtube.com
March 8, 2025 at 6:29 PM
How avoidance of research waste is now emphasized in the Declaration of Helsinki, and how you might want to improve some of your data management and analysis practices in light of this change (talk, 40 minutes).
www.youtube.com/watch?v=q1nb...
www.youtube.com/watch?v=q1nb...
Reposted
New post on dealing with missing baseline values in randomised trials that analyse change-from-baseline
open.substack.com/pub/tpmorris...
open.substack.com/pub/tpmorris...
March 6, 2025 at 4:44 PM
New post on dealing with missing baseline values in randomised trials that analyse change-from-baseline
open.substack.com/pub/tpmorris...
open.substack.com/pub/tpmorris...
Reposted
A revised version of the paper with @poschm.bsky.social and Franz Koenig on stratification and covariate adjustment in clinical trials is now up arxiv.org/pdf/2408.06760
We thank Robin Ristl and @timpmorris.bsky.social for helpful comments.
We thank Robin Ristl and @timpmorris.bsky.social for helpful comments.
arxiv.org
March 4, 2025 at 10:49 AM
A revised version of the paper with @poschm.bsky.social and Franz Koenig on stratification and covariate adjustment in clinical trials is now up arxiv.org/pdf/2408.06760
We thank Robin Ristl and @timpmorris.bsky.social for helpful comments.
We thank Robin Ristl and @timpmorris.bsky.social for helpful comments.
Reposted
What is meant by a 'while on treatment' estimand? thestatsgeek.com/2025/03/03/w...
March 3, 2025 at 1:02 PM
What is meant by a 'while on treatment' estimand? thestatsgeek.com/2025/03/03/w...
Reposted
Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!
#OTD 28 Jan 1809 Louis-Dominique-Jules Gavarret b (d 30 Aug 1890) An early proponent of the 'statistical method' in medicine, his 1840 book 'Principes de Statistique Médicale' was among the first to describe statistical principles for rigorous clinical trial conduct. /10 🧵
January 28, 2025 at 12:26 PM
Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!
Reposted
Working on a factorial trial? The Explanation and Elaboration paper for the CONSORT and SPIRIT factorial extensions is now out in @bmj.com
It includes:
-examples of how to report factorial trials
-a methodology summary around the design/conduct/analysis of these trials
www.bmj.com/content/388/...
It includes:
-examples of how to report factorial trials
-a methodology summary around the design/conduct/analysis of these trials
www.bmj.com/content/388/...
Guidance for protocol content and reporting of factorial randomised trials: explanation and elaboration of the CONSORT 2010 and SPIRIT 2013 extensions
This report presents the explanation and elaboration paper for the CONSORT (Consolidated Standards of Reporting Trials) 2010 and SPIRIT (Standard Protocol Items: Recommendations for Interventional Tri...
www.bmj.com
February 4, 2025 at 11:03 AM
Working on a factorial trial? The Explanation and Elaboration paper for the CONSORT and SPIRIT factorial extensions is now out in @bmj.com
It includes:
-examples of how to report factorial trials
-a methodology summary around the design/conduct/analysis of these trials
www.bmj.com/content/388/...
It includes:
-examples of how to report factorial trials
-a methodology summary around the design/conduct/analysis of these trials
www.bmj.com/content/388/...
Reposted
The relative efficiency of staircase and stepped wedge cluster randomised trial designs journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
February 28, 2025 at 9:17 AM
The relative efficiency of staircase and stepped wedge cluster randomised trial designs journals.sagepub.com/doi/full/10....
Reposted
1/3
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
February 13, 2025 at 12:04 PM
1/3
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Reposted
Ensuring a trial has an independent data monitoring committee (DMC) is crucial to the safety and oversight of clinical trials. But a question this week was whether there is ever a scenario where a DMC might legitimately be deemed not to be essential 1/8
#MethodologyMonday #110
#MethodologyMonday #110
February 3, 2025 at 7:31 AM
Ensuring a trial has an independent data monitoring committee (DMC) is crucial to the safety and oversight of clinical trials. But a question this week was whether there is ever a scenario where a DMC might legitimately be deemed not to be essential 1/8
#MethodologyMonday #110
#MethodologyMonday #110
It is really a scandal: www.bbc.co.uk/news/uk-engl...
Nottingham hospitals: NHS paid out £101m over maternity failings
The two hospitals in Nottingham are at the centre of a major inquiry into baby deaths and injuries.
www.bbc.co.uk
February 2, 2025 at 5:45 PM
It is really a scandal: www.bbc.co.uk/news/uk-engl...
Reposted
Oh my lord it's christmas come early! I didn't even realize the authors had written a reply, but they did, and it's glorious! 😆 More than I could have ever dreamed of.
cc @timpmorris.bsky.social (link in next post)
cc @timpmorris.bsky.social (link in next post)
Sincere kudos to the editors of the American Journal of Gastroenterology for publishing our letter (with @timpmorris.bsky.social).
journals.lww.com/ajg/citation...
journals.lww.com/ajg/citation...
January 28, 2025 at 10:17 PM
Oh my lord it's christmas come early! I didn't even realize the authors had written a reply, but they did, and it's glorious! 😆 More than I could have ever dreamed of.
cc @timpmorris.bsky.social (link in next post)
cc @timpmorris.bsky.social (link in next post)
Reposted
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
January 17, 2025 at 1:58 PM
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
NHS has been struggling and the situation is unfortunately getting worse: www.bbc.co.uk/news/article...
Patients dying in hospital corridors, say nurses
The Royal College of Nursing details harrowing cases from more than 5,000 nurses across the UK.
www.bbc.co.uk
January 16, 2025 at 9:36 AM
NHS has been struggling and the situation is unfortunately getting worse: www.bbc.co.uk/news/article...
Reposted
Our team—Leila, Suzie, Rachel, and Ellie—in collaboration with Xinxu from the OVG and Claire Waddington published a new article, “Past, Present and Future of Phase 3 Vaccine Trial Design: Rethinking Statistics for the 21st Century.” It’s worth a read!
academic.oup.com/cei/advance-...
academic.oup.com/cei/advance-...
Past, present, and future of Phase 3 vaccine trial design: rethinking statistics for the 21st century
This paper provides an overview of the evolution of Phase 3 vaccine trial design and statistical analysis methods from traditional to more innovative conte
academic.oup.com
January 14, 2025 at 8:09 AM
Our team—Leila, Suzie, Rachel, and Ellie—in collaboration with Xinxu from the OVG and Claire Waddington published a new article, “Past, Present and Future of Phase 3 Vaccine Trial Design: Rethinking Statistics for the 21st Century.” It’s worth a read!
academic.oup.com/cei/advance-...
academic.oup.com/cei/advance-...
Reposted
Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...
www.bmj.com
January 8, 2025 at 11:47 AM
Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Reposted
New paper led by Thomas Drury arxiv.org/abs/2412.12380
The Estimand Framework and Causal Inference: Complementary not Competing Paradigms
The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical trials. However, it is...
arxiv.org
December 21, 2024 at 8:16 AM
New paper led by Thomas Drury arxiv.org/abs/2412.12380
Reposted
The proposition facing patients for most drug trials isn't "you will be given placebo, or some miracle drug"
It's "you will be given the standard of care you would receive if not enrolled on the trial plus a placebo, or that standard of care plus a new drug that may or may not be effective"
It's "you will be given the standard of care you would receive if not enrolled on the trial plus a placebo, or that standard of care plus a new drug that may or may not be effective"
December 19, 2024 at 1:44 PM
The proposition facing patients for most drug trials isn't "you will be given placebo, or some miracle drug"
It's "you will be given the standard of care you would receive if not enrolled on the trial plus a placebo, or that standard of care plus a new drug that may or may not be effective"
It's "you will be given the standard of care you would receive if not enrolled on the trial plus a placebo, or that standard of care plus a new drug that may or may not be effective"
Reposted
Christmas 2024 Gift no. 4
NEW VIDEO:
"IPD Meta-Analysis: Two-stage or Not Two-Stage?
That is the question..."
youtu.be/WFSAfouhB-8
- guidance for when to choose a one-stage rather than a two-stage approach, & vice versa.
- ideas showcased using real examples (no equations)
I hope useful!
NEW VIDEO:
"IPD Meta-Analysis: Two-stage or Not Two-Stage?
That is the question..."
youtu.be/WFSAfouhB-8
- guidance for when to choose a one-stage rather than a two-stage approach, & vice versa.
- ideas showcased using real examples (no equations)
I hope useful!
IPD Meta-Analysis: Two-stage or Not Two-Stage? That is the question ...
YouTube video by Richard_D_Riley
youtu.be
December 17, 2024 at 9:44 AM
Christmas 2024 Gift no. 4
NEW VIDEO:
"IPD Meta-Analysis: Two-stage or Not Two-Stage?
That is the question..."
youtu.be/WFSAfouhB-8
- guidance for when to choose a one-stage rather than a two-stage approach, & vice versa.
- ideas showcased using real examples (no equations)
I hope useful!
NEW VIDEO:
"IPD Meta-Analysis: Two-stage or Not Two-Stage?
That is the question..."
youtu.be/WFSAfouhB-8
- guidance for when to choose a one-stage rather than a two-stage approach, & vice versa.
- ideas showcased using real examples (no equations)
I hope useful!
Reposted
This is how the Chengdu it…reflections from our recent academic and clinical wcchange visit with colleages in Chengdu, China acha.qmul.ac.uk/research/ach...
ACHA China Expedition - Academic Centre for Healthy Ageing
acha.qmul.ac.uk
December 18, 2024 at 11:00 AM
This is how the Chengdu it…reflections from our recent academic and clinical wcchange visit with colleages in Chengdu, China acha.qmul.ac.uk/research/ach...
Reposted
Fame at last (for my substack)!
tpmorris.substack.com
tpmorris.substack.com
December 18, 2024 at 1:19 PM
Fame at last (for my substack)!
tpmorris.substack.com
tpmorris.substack.com
Reposted
Christmas 2024 Gift no. 3
NEW VIDEO: "Christmas Day of The Doctor" (8 mins)
Are #DoctorWho Christmas episodes good for health?
What's the evidence from a BMJ study?
What's the impact of the work?
And what's the online feedback been?
All is revealed .... enjoy 😜
www.youtube.com/watch?v=AtQ5...
NEW VIDEO: "Christmas Day of The Doctor" (8 mins)
Are #DoctorWho Christmas episodes good for health?
What's the evidence from a BMJ study?
What's the impact of the work?
And what's the online feedback been?
All is revealed .... enjoy 😜
www.youtube.com/watch?v=AtQ5...
Christmas Day of The Doctor! Doctor Who festive episodes & lower UK mortality rates - a BMJ study
YouTube video by Richard_D_Riley
www.youtube.com
December 16, 2024 at 2:42 PM
Christmas 2024 Gift no. 3
NEW VIDEO: "Christmas Day of The Doctor" (8 mins)
Are #DoctorWho Christmas episodes good for health?
What's the evidence from a BMJ study?
What's the impact of the work?
And what's the online feedback been?
All is revealed .... enjoy 😜
www.youtube.com/watch?v=AtQ5...
NEW VIDEO: "Christmas Day of The Doctor" (8 mins)
Are #DoctorWho Christmas episodes good for health?
What's the evidence from a BMJ study?
What's the impact of the work?
And what's the online feedback been?
All is revealed .... enjoy 😜
www.youtube.com/watch?v=AtQ5...