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Reposted by Hakhamanesh Mostafavi

Roshni Patel @roshnipatel.bsky.social · Aug 6

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

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Yun S. Song @yun-s-song.bsky.social · Jun 6

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io

Please help spread the news.

Home - ProbGen 2026

Your Site Description

probgen2026.github.io

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Hakhamanesh Mostafavi @hakha.bsky.social · Jul 26

Thanks Jazlyn!

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Hakhamanesh Mostafavi @hakha.bsky.social · Jul 25

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

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Hakhamanesh Mostafavi @hakha.bsky.social · Jul 21

A brief musical note: I’m very excited to share that my brilliant wife, a pianist and composer, has just released her debut album featuring works by Iranian women composers, including one of her own. Here is the link in case you’d like to take a listen: www.navonarecords.com/catalog/nv67...

Nahoft – Navona Records

Drawing its name from a melodic motif found in Iranian music, NAHOFT is the culmination of pianist Ava Nazar’s collaboration with the Iranian Female Composers Association, showcasing six woman compose...

www.navonarecords.com

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Jonathan Pritchard @jkpritch.bsky.social · Jul 7

Staff scientist position (computational):

I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record.
#sciencejobs

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Hakhamanesh Mostafavi @hakha.bsky.social · Jun 17

It was fun writing this short piece on the omnigenic model. Sharing it here, though it's a painful time as my family, along with millions of others, is at risk in Iran and the region.

Nature Reviews Genetics @natrevgenet.nature.com · Jun 16

New online! Making sense of the polygenicity of complex traits

Making sense of the polygenicity of complex traits

Nature Reviews Genetics, Published online: 16 June 2025; doi:10.1038/s41576-025-00866-7Hakhamanesh Mostafavi recalls a landmark paper by Boyle et al. on the omnigenic model, which proposed that complex traits are influenced by thousands of genes across the genome, including many that are only indirectly related to a trait through regulatory networks.

www.nature.com

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Julia M. Rohrer @dingdingpeng.the100.ci · May 11

Thanks to everybody who chimed in!

I arrived at the conclusion that (1) there's a lot of interesting stuff about interactions and (2) the figure I was looking for does not exist.

So, I made it myself! Here's a simple illustration of how to control for confounding in interactions:>

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Molly Przeworski @mollyprz.bsky.social · Apr 29

Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

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Hakhamanesh Mostafavi @hakha.bsky.social · Apr 28

I've been singing with the Bronx County Chorus since 2015. It's a beautiful, intergenerational community bringing free music to the Bronx since the 1930s. With grants shrinking, they now need support to keep going. If you can, please consider helping: www.gofundme.com/f/support-th...

Donate to Support the Longest Running Community Chorus in the Bronx!, organized by Denise Wharton

Keep the Bronx Singing – Support the Bronx County Chorus! … Denise Wharton needs your support for Support the Longest Running Community Chorus in the Bronx!

www.gofundme.com

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Molly Przeworski @mollyprz.bsky.social · Apr 24

Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.

2025 Human Genetics and Genomics Conference GRC

The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.

www.grc.org

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Jeff Spence @jeffspence.github.io · Mar 28

A really nice paper by @drghawkes.bsky.social et al. argues that rare and common genetic associations converge on the same genes.

While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6)

www.biorxiv.org/content/10.1...

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations

Genetic association studies have mostly focussed on common variants from genotyping arrays or rare protein-coding variants from exome sequencing. Here, we used whole-genome sequence (WGS) data in 672,...

www.biorxiv.org

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Tuuli Lappalainen @tuuliel.bsky.social · Jan 14

One month to go until the CSHL Biology of Genomes abstract deadline! My all-time fav meeting, and one of the few covering genomics broadly. We have a ✨🤩 lineup of speakers, but it's the abstract talks & posters that really make the meeting - send us your best work! meetings.cshl.edu/meetings.asp...

Topics:
Population Genomics
Evolutionary & Non-human Genomics
Cancer Genomics
Computational & Statistical Genomics
Complex Traits & Genomic Medicine
Functional Genomics
Emerging Methods & Technologies

Keynote Speakers:
Steve McCarroll, Broad Institute of MIT and Harvard
Trisha Wittkopp, University of Michigan

Discussion Leaders:
Nadav Ahituv, University of California, San Francisco
Gemma Carvill, Northwestern University
Nancy Chen, University of Rochester
Gilad Evrony, New York University
Simon Gravel, McGill University, Canada
Stephanie Hicks, Johns Hopkins University
Nada Jabado, McGill University, Canada
Andrew Kern, University of Oregon
Nicholas Mancuso, University of Southern California
Sara Mostafavi, University of Washington
Nicholas Navin, MD Anderson Cancer Center
Soumya Raychaudhuri, Broad Institute of MIT and Harvard
Gloria Sheynkman, University of Virginia School of Medicine
Peter Sudmant, University of California, Berkeley

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Samuel Pattillo Smith @sampatsmith.bsky.social · Feb 4

Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]

A Litmus Test for Confounding in Polygenic Scores

Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...

www.biorxiv.org

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bioRxiv Genetics @biorxiv-genetic.bsky.social · Feb 1

The distribution of highly deleterious variants across human ancestry groups https://www.biorxiv.org/content/10.1101/2025.01.31.635988v1

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JT Neal @jtneal.bsky.social · Jan 27

Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...

(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)

A genome-wide atlas of human cell morphology - Nature Methods

An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...

www.nature.com

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Sasha Gusev @sashagusevposts.bsky.social · Jan 20

How population stratification makes environments look like genes. A short 🧵:

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Jonathan Pritchard @jkpritch.bsky.social · Jan 26

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?

I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

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Jonathan Pritchard @jkpritch.bsky.social · Jan 24

Very excited about this new work from our lab! Explainer thread coming soon
@minetoota.bsky.social

bioRxiv Genetics @biorxiv-genetic.bsky.social · Jan 24

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq https://www.biorxiv.org/content/10.1101/2025.01.22.634424v1

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Matt Ming @mattjming.bsky.social · Jan 14

I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14)

www.cell.com/ajhg/fulltex...

No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection

We assess the evidence for a genome-wide relationship between sex differences in gene expression and sex differences in natural selection. We develop an improved model for testing this association but...

www.cell.com

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Doc Edge @docedge.bsky.social · Jan 10

Our daughter's wonderful teacher and her family lost everything in the Eaton fire. If you can spare a few dollars to help out, I would be grateful www.gofundme.com/f/help-the-l...

Donate to Help the Lim Family rebuild after the Altadena Eaton Fire, organized by roy yoo

On Wednesday, January 7th, the devastating Eaton fire in Altadena, C… roy yoo needs your support for Help the Lim Family rebuild after the Altadena Eaton Fire

www.gofundme.com

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Axel Visel @axelvisel.bsky.social · Jan 8

Now available as preprint:

The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs

www.biorxiv.org/content/10.1...

Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4

Schematic overview of the ENCODE 4 project's framework for identifying and classifying candidate cis-regulatory elements (cCREs). The process begins by defining regulatory anchors, such as DNase hypersensitive sites (rDHSs) and transcription factor (TF) clusters, which are filtered and classified using histone marks and other features. Elements are classified into functional categories, including promoters, proximal and distal enhancers, and CTCF-bound sites. The resulting registry includes millions of cCREs for human (GRCh38) and mouse (mm10), depicted alongside their classifications. Additional annotations, such as transcription activity, chromatin structure, genetic variation, and sequence motifs, are integrated for functional characterization. Image modified from https://www.biorxiv.org/content/10.1101/2024.12.26.629296v1.full

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Hakhamanesh Mostafavi @hakha.bsky.social · Jan 6

We welcome work addressing key questions in human complex trait genetics, offering insights that can broadly advance how we understand and interpret the genetics of traits.

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Hakhamanesh Mostafavi @hakha.bsky.social · Jan 6

I’m thrilled to join #GENETICS as an associate editor!

Genetics Society of America @genetics-gsa.bsky.social · Jan 6

Welcome new associate editor @hakha.bsky.social to #GENETICS👋 His lab develops computational and theoretical approaches to study the genetic basis and #biology of human complex traits and diseases.

Read more: bit.ly/3BYIngc

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Branden McEuen but he’s spooky @bmceuen.bsky.social · Dec 27

I truly think teaching the complexities of inheritance to demonstrate that it’s more than simple Mendelian genetics that explains traits would help reduce the number of people who believe in genetic determinism. Disease would be a fruitful start to that but it can be applied to a variety of traits

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