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Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Doc Edge @docedge.bsky.social · Aug 12

For the pros, they teach "Another One Bites the Dust"

(wife is in healthcare)

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Roshni Patel @roshnipatel.bsky.social · Aug 6

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

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Graham Coop @gcbias.bsky.social · Jun 7

The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.

Federal investment in UC research Federal funds are the university’s single most important source of support for research, accounting for more than half of UC’s total research awards.

Many of California’s leading industries grew from UC research, including biotechnology, computing, semiconductors, telecommunications and
agriculture.

Providing health care at UC University of California Health (UC Health) is one of the nation’s largest public academic health systems, serving
as a critical part of the California safety net.

UC trains approximately 36% of the medical residents in California

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Jeff Spence @jeffspence.github.io · Jun 2

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.

We'll work at the intersection of statistical genetics, population genetics, and machine learning.

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Genetics Society of America @genetics-gsa.bsky.social · Jun 3

Jennifer Blanc and @jeremyjberg.bsky.social use theory and simulations to study the process of testing for an association between polygenic scores and axes of ancestry variation when confounding factors are present.

Learn more about their findings in #GENETICS: buff.ly/EmKpXyP

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NSF-Simons NITMB @nitmb.bsky.social · Jun 2

Welcome to the Modeling and Theory in Population Biology workshop!

We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...

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Doc Edge @docedge.bsky.social · May 27

I have loved this song with my whole heart since first hearing it, almost 20 years ago now

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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · May 22

Harvard has just under 6,800 foreign students enrolled. Every one of them would have to give up their dreams of an education in the US or transfer elsewhere, if Noem's attack on Harvard is upheld.

None of them have done anything wrong, they're just collateral damage to Trump.

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Arun Durvasula @arundurvasula.bsky.social · May 22

Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...

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Doc Edge @docedge.bsky.social · May 14

Absolutely awful. I'm so sorry

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Michael Baym @baym.lol · May 13

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

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Molly Przeworski @mollyprz.bsky.social · Apr 29

Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

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Genetics Society of America @genetics-gsa.bsky.social · Apr 29

In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and @docedge.bsky.social, show the effect of various choices made while computing Q-ST.

Read more: buff.ly/OwrU9oB

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Genetics Society of America @genetics-gsa.bsky.social · Apr 28

In a new #GENETICS research, @dandanpeng.bsky.social, Mulder, and @docedge.bsky.social evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score.

Read more: buff.ly/ztrRU83

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Alex Strudwick Young @alextisyoung.bsky.social · Apr 28

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

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Graham Coop @gcbias.bsky.social · Apr 24

I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.

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Janis Liu @jjliu98.bsky.social · Apr 18

My paper about type I error rates in Qst/Fst comparisons is now published in @genetics-gsa.bsky.social. Check it out here: academic.oup.com/genetics/adv...

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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · Apr 16

I don’t care whether he’s innocent. I care that he was denied the fundamental human rights of due process and equal protection under the law. Until those conditions are satisfied he is accorded the presumption of innocence.

Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · Apr 16

It's now been over a month since Trump sent innocent man Andry Hernández to one of the world's worst prisons because of "Mom" and "Dad" tattoos. Like the others, he is being imprisoned with no contact with the outside world.

Don't let him be forgotten.

A selfie of Andry José Hernández Romero, in better times, standing in front of a rainbow arch of balloons.

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Jeff Groh @jeffgroh.bsky.social · Apr 10

Inspired by others on here I wrote a short op-ed in support of federal research funding for a local newspaper in small town PA where I grew up

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Arslan Zaidi @aazaidi.bsky.social · Apr 9

An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.

Interpreting SNP heritability in admixed populations

SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of heritability (h2), being equal to it if all causal varia...

www.biorxiv.org

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Doc Edge @docedge.bsky.social · Apr 8

Perhaps the oldest recorded example

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Doc Edge @docedge.bsky.social · Apr 7

Editing a genome to Ernst Mayr's genotype so that when clone Ernst grows up, he can tell us whether these are dire wolves

David Pollock @genomesevolve.bsky.social · Apr 7

I am curious how much DNA from dire wolves they actually put in. "Colossal, a genetics startup, has birthed three pups that contain ancient DNA retrieved from the remains of the animal’s extinct ancestors" (New Yorker). Is this a gene or two?

Do you know?

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Gideon Bradburd @gbradburd.bsky.social · Mar 28

Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry

www.science.org/doi/10.1126/...

A geographic history of human genetic ancestry

Describing the distribution of genetic variation across individuals is a fundamental goal of population genetics. We present a method that capitalizes on the rich genealogical information encoded in g...

www.science.org

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Jonathan Cohn @jonathancohn.bsky.social · Mar 27

A stunning assault on the First Amendment

Before Rubio's confirmation, senators and pundits acted as though he was a "sane," "rational," "normal," "moderate" nominee. He's constantly showing himself to be a right-wing extremist.

New: Rubio confirmed he revoked the visa of the Tufts student and said he likely has revoked the visas of hundreds more. “We do it every day. Every time I find one of these lunatics, I take way their visas." The total # of revoked visas “might be more than 300 at this point"

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