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Reposted by Anthony Hessel, PhD

Julien Ochala @droch.bsky.social · 9d

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme

employment.ku.dk

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Reposted by Anthony Hessel, PhD

Jonathan Huie, PhD @jmhuie.bsky.social · Aug 28

Excited to share the first paper from my PhD!

We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪

DM for PDF

doi.org/10.1098/rspb...

Phylogeny of Aneides and Plethodon with animal photos

Phylomorphospace showing body shape variation

Morphospace of toe bones and box lots showing estimated gripping force

Representative SEM images of salamander feet

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Reposted by Anthony Hessel, PhD

Physiological Reports @physrep.bsky.social · 22d

This new #Methods article evaluates #freeze-drying to #RNAlater and three RNAlater-ICE-based protocols for #skeletal #muscle #biopsy tissue preservation for subsequent manual isolation of #fibers and other downstream applications.
doi.org/10.14814/phy...
#Physiology #MyoBlue

doi.org

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Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 21

Calling all BPS member / interested muscle people!!!

Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society.

*Signatures from active members are needed*, but anyone with an interest can sign.

Please help the cause!
www.change.org/p/establish-...

Sign the Petition

Establish a Dedicated Cardiac and Skeletal Muscle Research Subgroup Within The Biophysical Society

www.change.org

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Reposted by Anthony Hessel, PhD

Ken Campbell @cardiaccampbell.bsky.social · Aug 20

Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action.
www.pnas.org/doi/10.1073/...

Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/

Danicamtiv reduces myosin’s working stroke but activates the thin filament by accelerating actomyosin attachment | PNAS

Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As...

www.pnas.org

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Reposted by Anthony Hessel, PhD

Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · Aug 20

Can you really repair an engine while it's running? 👩🏽‍🔧

The heart can. 💪🏼🫀

Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼‍♀️🏊‍♂️

#Exercise #Heart #Muscle #BasicScience #Cardiology

faseb.onlinelibrary.wiley.com/doi/10.1096/...

Cardiac CapZ Regulation During Acute Exercise in Female Mice

CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During...

faseb.onlinelibrary.wiley.com

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Reposted by Anthony Hessel, PhD

Shicheng Guo @shihcheng.bsky.social · Aug 16

Global study: 2.08M people, 133 cohorts, 39 countries, 6 continents. 5 risk factors influence 50% of lifetime cardiovascular disease risk. PMID:40162648, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2415879 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMoa2415879

No description available

doi.org

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Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 5

...I explained to them about how research funding works for these kinds of things and how government should support them...and if they do agree with it, they should let their reps know. They asked how to let their reps know. So a small example of going out and interacting with the community.

Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 5

Dangerously, using the same argument could justify doing nothing ever for communication. That aside, balance online and other mediums. I find direct interaction helps. E.g., I talked with a group of American Legion members about leg amputation / protheses research and they were very engaged. Then...

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Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 5

That advantage of name recognition and such early on does impact the grant reviewers for sure. I am not a "genius" scientist, maybe just above mid. I just think I and my circle of fabulous mentors have carefully organized my pathway into staying in science...at least for a bit longer...

Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 5

This may be a bit strongly worded. Some people took initiative to write grants even when in a secure post doc. Some wrote grants that were tailored-made to be impactful/career boosting. IMHO, no problem with career strategy in an ultra competitive funding landscape. Wayyy more deserve than spots.

Paul Hünermund @p-hunermund.com · Aug 4

Academia is basically a collection of people who got lucky early on and mistook it for genius. doi.org/10.1073/pnas...

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Anthony Hessel, PhD @hesselanthony.bsky.social · Aug 5

Yes! NIAMS and NHLBI as well!

Patrick Phillips @patrickphillips.bsky.social · Aug 5

3. The POs for NIGMS and NIA have been phenomenal (as well as NIBIB, which is an aspiration for us). They have been very calm and reassuring, even as I know that their individual lives are very challenging. We are very lucky to have these staff and should be fighting for them whenever possible. 4/n

Reposted by Anthony Hessel, PhD

Lisa Whitenack, PhD @whitenacklab.bsky.social · Jul 31

Y’all!!! Our comparative anatomy textbook is out!!! Free, open access, and just in time for the fall semester!

Bill Ryerson @billryerson.bsky.social · Jul 30

New Comparative Anatomy Textbook! Completely free to read and open access!

doi.org/10.59319/YHF...

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Reposted by Anthony Hessel, PhD

Geoff Power @geoffpower.bsky.social · Jul 30

"The successful candidate will have expertise in area(s) related to cardiovascular physiology, metabolic regulation and dysregulation, and/or hormonal mechanisms that maintain homeostasis, with a focus on aging."

Elizabeth Rideout @ejrideout.bsky.social · Jul 30

Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on “Faculty Positions” on the page. Please help spread the word!

Careers | Department of Cellular & Physiological Sciences

cps.med.ubc.ca

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jul 18

All scientists need to be doing more of this and posting on all types of social media platforms (not just on the echo chamber communities). We must get better at communicating our science in a fun and effective way to a broad audience or tax payers/ voters.

The Conversation U.S. @us.theconversation.com · Jul 18

Tasty but invasive: Golden oyster mushrooms threaten forest biodiversity and fragile ecosystems already stressed by climate change. @uwmadison.bsky.social fungi expert Aishwarya Veerabahu reveals the dark side of escaped mushrooms
🧪 🌱 #mushrooms #mushroomhunting

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Reposted by Anthony Hessel, PhD

Joseph Gordon @josephwgordon.bsky.social · Jul 15

www.nature.com/articles/s41...

Muscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade - Nature Reviews Endocrinology

Nature Reviews Endocrinology - Muscle mass loss during GLP1 receptor agonist therapy prevented with GDF8 and activin A blockade

www.nature.com

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Reposted by Anthony Hessel, PhD

Grace Lindsay @neurograce.bsky.social · Jul 15

Day of Action planned for July 21 to protect science protectscienceandinnovation.org

Protect Science and Innovation

protectscienceandinnovation.org

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jul 13

NIH moves towards alternatives to animal models, in line with the shift in the EU. This is not bad policy in principal but not yet always feasible on technical grounds. It's important to continue searching for "muscles in a dish" that are of quality for Xray diffraction. Who wants to collab?

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Reposted by Anthony Hessel, PhD

Prasad Jallepalli, MD, PhD @prasad.bsky.social · Jul 12

nothing would make me happier than US science returning to the amazing and transformational legacy of success and dominance

but if that's not possible, we need other places with the vision to take over as the pacesetter

humanity's long term success demands no less

Australian Academy of Science @science.org.au · Jul 11

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...

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Reposted by Anthony Hessel, PhD

Glen Pyle | Womens Heart Health ❤️‍🩹🖇️ @glenpyle.bsky.social · Jul 10

I was delighted to accept the King Charles III Coronation Medal for my lab's research & advocacy for women's heart health.🫀💃🏻

We appreciate the support of IMPART at @dalhousie.bsky.social & @womensresearch.bsky.social, & were grateful to be nominated by the Heart & Stroke Foundation of Canada.

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Reposted by Anthony Hessel, PhD

The Journal of Physiology @jphysiol.bsky.social · Jul 2

Damien M. Callahan presents this #TranslationalPerspective on the work of Laitila et al. linking altered structure and post-translational modification of Troponin T to dystonia in nemaline myopathies💭 ✍️

🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jun 27

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads.
rdcu.be/etNxf

Titin-Based Force Modulates Cardiac Thick and Thin Filaments
lnkd.in/ef6veRyT

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads

Nature Communications - Myosin-binding protein C (MyBP-C) resides and interacts with the myosin filaments in striated muscle and regulates contraction via an unclear mechanism. Here, the authors...

rdcu.be

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jun 27

The distinctive mechanical and structural signatures of residual force enhancement in myofibers
DOI link: lnkd.in/eaAZb4QG

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jun 27

Here is a list of some of the papers that are recognized by the prize:

Titin force in muscle cells alters lattice order, thick and thin filament protein formation
DOI link:
www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Anthony Hessel, PhD @hesselanthony.bsky.social · Jun 27

The entire group at the University of Münster, Insitute of Physiology II also deserve a standing ovation! And finally, my wonderful partner Anna Good and lovely dogs.

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