Lightnews — Scholar-powered news

Ian Kelsall @iankelsall.bsky.social · 20h

The last population of woolly mammoths became extinct nearly 1,000 years after the Great Pyramid of Giza was completed. Theoretically many of Eygpt's pharaohs could have hunted mammoth, had they possessed the means to travel so far north.

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Reposted by Ian Kelsall

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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Reposted by Ian Kelsall

Flum @flumcake.bsky.social · 16d

Get in loser, we’re going to the rapture.

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Russell Garner @rgarner.bsky.social · 16d

RAPTCHA

A CAPTCHA layout with the central Bosch triptych from The Last Judgement:

Select all squares with
THE DAMNED
If there are none, click skip

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Ian Kelsall @iankelsall.bsky.social · 26d

If you enjoyed Blood Meridian then I might suggest "The Son" by Philipp Meyer. Perhaps not as gore filled, but still a pretty brutal cowboy romp. Oh, and "Waiting for the Barbarians" by JM Coetzee is a book I would recommend to anybody who will listen!

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Ian Kelsall @iankelsall.bsky.social · 28d

Indestructible and difficult to misplace I guess. It looks like second-hand ones can still be picked up quite cheap in Ebay etc. I'd naïvely assumed that everybody just used a big stick to point before the arrival of the laser pointer!
vintagelens.nl/product/vint...

Vintage 1960s 1970s Arrow pointer for slide projections - Vintagelens

Vintage 1960s 1970s Arrow pointer for slide projections tested and working

vintagelens.nl

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Reposted by Ian Kelsall

HappyToast @happytoast.co.uk · 28d

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Ian Kelsall @iankelsall.bsky.social · 29d

Look at the size of that pointer! That thing looks like a lightsabre.

Alexey Amunts @amunts.bsky.social · 29d

1973: Max Perutz explains the solution of hemoglobin. 53 years later, we’re still waiting for someone to solve the missing pointer

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Reposted by Ian Kelsall

ahellab.bsky.social @ahellab.bsky.social · Sep 8

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
rdcu.be/eETIT

The rise of ADP-ribose–ubiquitin

Nature Structural & Molecular Biology - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational...

rdcu.be

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Reposted by Ian Kelsall

Private Eye Magazine @privateeyenews.bsky.social · Sep 9

Art class

From the latest Private Eye, out now.

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Ian Kelsall @iankelsall.bsky.social · Sep 3

Congratulations Sonja!

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Prof Frank McDonough @fxmc1957.bsky.social · Sep 2

FACT OF THE DAY. 2 September 1752. Britain replaced the Julian calendar with the Gregorian one which was used in most of Europe. The following day was 14 September 1752, meaning 11 days were cut from the 1752 British calendar. These days simply never existed.

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Reposted by Ian Kelsall

Andy Parmo @andyparmo.co.uk · Aug 29

Your mam shouts at hotels and your dad paints roundabouts

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Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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Ian Kelsall @iankelsall.bsky.social · Aug 28

Congratulations!

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Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

www.cell.com

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Reposted by Ian Kelsall

IMP @impvienna.bsky.social · Aug 28

Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...

ZNFX1 compacts and tags RNA to keep immunity in check

Tim Clausen’s lab at the IMP and collaborators have uncovered how the ancient immune protein ZNFX1 enables cells to walk the fine line between fighting infection and avoiding autoimmune damage. The te...

www.imp.ac.at

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Reposted by Ian Kelsall

Drew Harwell @drewharwell.com · Aug 19

Showing the endangered leader of an invaded country my hats

President @realDonaldTrump showing President Zelenskyy and President Macron his 4 More Years hat 🤣🇺🇸

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Ian Kelsall @iankelsall.bsky.social · Jul 25

Oh no thank you! Insects should not be that big!

a man with dreadlocks and a beard is making a funny face while wearing a white tank top .

ALT: a man with dreadlocks and a beard is making a funny face while wearing a white tank top .

media.tenor.com

Reposted by Ian Kelsall

Jonny Edwards @veritasgaston.bsky.social · Jul 22

An incomparable legend.

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The original beardy Bill⚓️ @beardybill1.bsky.social · Jul 12

Installing microwave ovens is hardly a tough gig is it? Put it on the worktop, plug it in- bosh. Money for nothing #liveaid

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Ian Kelsall @iankelsall.bsky.social · Jun 30

Who's that weird man with Olivia Rodrigo daddy?
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025

THE CUREverse @thecureverse.bsky.social · Jun 30

#OliviaRodrigo & #RobertSmith • Just Like Heaven • #Glastonbury2025

Reposted by Ian Kelsall

Ted Pavlic (he/him/his) @tedpavlic.bsky.social · Jun 8

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific

A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

www.richmondscientific.com

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Ian Kelsall @iankelsall.bsky.social · Jun 8

A great song, but those lyrics about "the touch of the younger kind" have not aged well.

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Ian Kelsall @iankelsall.bsky.social · Jun 6

Thanks Simon, it was great to meet you too (even if it was only briefly)!