Simone Immler
@immler.bsky.social
710 followers 1.1K following 9 posts
Professor of Genetics & Reproduction, University of East Anglia Founder and Scientific Director, Virilitas Labs
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immler.bsky.social
This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility.

Happy to be part of this exciting study!
alexeimaklakov.bsky.social
Why does eating less extend lifespan? 🧬

Mutation accumulation underpins evolution of lifespan extension by dietary restriction

We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵

🔗 tinyurl.com/jn5ryhxv
immler.bsky.social
Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…
Reposted by Simone Immler
zebrafishrock.bsky.social
Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪

#WomenInScience (Volume 1): go.bsky.app/4BegEjv
#WomenInScience (Volume 2): go.bsky.app/VoebYrt
Reposted by Simone Immler
physaliacourses.bsky.social
🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work...

#Genomics #Bioinformatics #GenomeAssembly
Reposted by Simone Immler
odedrechavi.bsky.social
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
Reposted by Simone Immler
miguelgf.bsky.social
New model of premature #aging in #zebrafish 👏
"Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration."
Go Fish! 🐟

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
Reposted by Simone Immler
physaliacourses.bsky.social
Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28).
You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans

Limited spots! 👉 www.physalia-courses.org/courses-work...
GENOME-WIDE PREDICTION OF COMPLEX TRAITS
Dates 24-28 March 2025 To foster international participation, this course will be held online
www.physalia-courses.org
Reposted by Simone Immler
zebrafishrock.bsky.social
Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪
Hand-drawn images of zebrafish from 21 days post fertlization (dpf)(top), 36dpf and 7dpf. Anterior to left. You can see the eye and tails of the fish with the distinct stripes.
Reposted by Simone Immler
caseywdunn.bsky.social
Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs
GitHub - caseywdunn/sharkmer
Contribute to caseywdunn/sharkmer development by creating an account on GitHub.
github.com
Reposted by Simone Immler
immler.bsky.social
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!

And enjoy the fish 🐟 eating the Pi(e) 🥧
alicegodden.bsky.social
🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
FishPi software logo
Reposted by Simone Immler
zebrafishrock.bsky.social
FishPi software is freely available here: github.com/alicegodden/...
immler.bsky.social
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!

And enjoy the fish 🐟 eating the Pi(e) 🥧
alicegodden.bsky.social
🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
FishPi software logo
Reposted by Simone Immler
erictopol.bsky.social
Reversing Type 2 diabetes
A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
immler.bsky.social
Pm me if interested - we had an incidence where we needed the info related to building works
immler.bsky.social
I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement
fabianlab.bsky.social
Developing #zebrafish embryos about 18 hours post fertilization. Can you see the tail or eye?
immler.bsky.social
Great to see this out! Congratulations Rowan, Paco and John!!