Lightnews — Scholar-powered news

Miguel Godinho Ferreira @miguelgf.bsky.social · 14d

Interested in cGAS-STING? Come and join us on 21st of October 2025 (9:30-12:30) in Nice, France!

univ-cotedazur.fr/recherche-in...

Nucleic acid sensing and innate immunity - Academy 4 Seminar Series #19 - Le Galet CHU PASTEUR NICE - October 21st, 2025 - Université Côte d'Azur

univ-cotedazur.fr

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Reposted by Miguel Godinho Ferreira

Mayor of London, Sadiq Khan @london.gov.uk · 22d

In London, hate will never win.

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Miguel Godinho Ferreira @miguelgf.bsky.social · 23d

Aging: “So far, no one has managed to rejuvenate anyone.” What are #telomeres? How can #zebrafish help in the study of #aging? Miguel Godinho Ferreira, a Portuguese scientist working in France, answers. Let's talk about longevity and aging.

(Portuguese only)
www.publico.pt/2025/09/16/c...

Envelhecimento: “Até agora, ninguém conseguiu rejuvenescer ninguém”

O que são os telómeros? Como pode o peixe-zebra ajudar no estudo do envelhecimento? Miguel Godinho Ferreira, cientista português a trabalhar em França, responde. Falemos então sobre a longevidade.

www.publico.pt

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Miguel Godinho Ferreira @miguelgf.bsky.social · 26d

Great opportunity to meet with French zebrafish community! Our lab will gladly join! Go fish! 🐟

Anabela Bensimon-Brito @bensimonbrito.bsky.social · 26d

🚨 Don’t miss it! Abstract submission closes Monday, Sept 15. frenchzebrafishmeeting.fr
Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish

French Zebrafish Meeting @frenchzebrafish.bsky.social · Aug 26

2nd French Zebrafish Meeting : Abstract's submission deadline extended to September 15th 2025.
Spread the word ... Registration deadline : October 10th.
More info on www.frenchzebrafishmeeting.fr
#zebrafish #FZM2025 #scientificcommunity #biology #behavior #diseasemodels #regeneration #evolution

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Miguel Godinho Ferreira @miguelgf.bsky.social · Sep 7

It is so nice to have this trail on our recent work. Thank you, @cyrilpedia.bsky.social! The follow up is just around the corner! 🙂

Thiago Carvalho @cyrilpedia.bsky.social · Sep 7

'Telomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in #zebrafish.'

www.embopress.org/doi/full/10....

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Reposted by Miguel Godinho Ferreira

Luis J. Castro-Vega @luiscastro-vega.bsky.social · Sep 1

www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

www.embopress.org

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Reposted by Miguel Godinho Ferreira

The EMBO Journal @embojournal.org · Sep 2

Comment in issue 17: Making sense of oxygen sensing
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...

This cover highlights the article cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish by Naz Şerifoğlu, Miguel Godinho Ferreira and colleagues. cGAS-STING are responsible for the premature aging of telomerase-deficient zebrafish. Short telomeres lead to genomic instability, inducing cGAS-STING pathway stimulation. cGAS-STING pathway inactiva-tion halts DNA damage response in the presence of short telomeres and rescues tissue proliferation, leading to overall recovery of organism fitness and survival. The front cover image shows the PCNA staining of intestinal tissues from Sting-deficient zebrafish.
Scientific image by N. Şerifoğlu

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Miguel Godinho Ferreira @miguelgf.bsky.social · Sep 1

Our paper was offered the cover of The EMBO Journal. 😀
We discovered that activation of cGAS-STING causes aging in response to very short telomeres. Zebrafish deficient in telomerase and sting, reverse premature death, reduced fertility, frailty and cancer.
👉 tinyurl.com/nhd4bfb9

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

www.embopress.org

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Miguel Godinho Ferreira @miguelgf.bsky.social · Aug 29

Not all species age the same way 😉
“We conclude that M. musculus maintains long telomeres in blood and tail throughout life”
Congrats Rhian and Dudy et al! 👏

House mouse maintains constant telomere length throughout life
url: academic.oup.com/nar/article/...

The house mouse maintains constant telomere length throughout life

Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length

academic.oup.com

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Reposted by Miguel Godinho Ferreira

Gulbenkian Institute for Molecular Medicine @gimmfoundation.bsky.social · Aug 22

What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it.

🔗 gimm.pt/pt-pt/gimm-festival/#program

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jul 19

Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation.
Go Fish! 🐟🐟🐟
www.thno.org/v15p7308.htm

Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration

www.thno.org

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 26

Thank you, Kevin! Your work will be sorely missed... "So long and thanks for all the fish!" 🐟

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Reposted by Miguel Godinho Ferreira

preLights @prelights.bsky.social · Jun 18

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights

Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

prelights.biologists.com

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Reposted by Miguel Godinho Ferreira

Zebrafish Rock! @zebrafishrock.bsky.social · Jun 18

Highlights work from @miguelgf.bsky.social et al. 🐟

preLights @prelights.bsky.social · Jun 18

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights

Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

prelights.biologists.com

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 18

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author paper of Bruno Lopes-Bastos.
We are very happy for this!

Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 18

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author manuscript of Bruno Lopes-Bastos.
We are very happy for this!

Zebrafish Rock! @zebrafishrock.bsky.social · Jun 18

Highlights work from @miguelgf.bsky.social et al. 🐟

preLights @prelights.bsky.social · Jun 18

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 12

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts.
Secure your spot on: gimm.pt/gimm-festival/
@nataging.nature.com

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 10

Here’s the EMBO Journal highlight on our paper!

The EMBO Journal @embojournal.org · Jun 10

How do shortened telomeres affect organismal health-/lifespan?
Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling
www.embopress.org/doi/full/10....

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Reposted by Miguel Godinho Ferreira

Cell Biology J-Club @cellclub.bsky.social · Jun 9

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

www.embopress.org

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Reposted by Miguel Godinho Ferreira

Aging Science News @agingbiology.bsky.social · Jun 9

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish
www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

www.embopress.org

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 5

It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice.

"Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"

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Reposted by Miguel Godinho Ferreira

Carl Zimmer @carlzimmer.com · Jun 4

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

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Miguel Godinho Ferreira @miguelgf.bsky.social · Jun 4

TODAY - You are still on time for early bird registration for the GIMM Festival on #Aging and #Longevity!
Lisbon from 4–6 September 2025.

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Reposted by Miguel Godinho Ferreira

Björn Schumacher @bjornschumacher.bsky.social · May 29

GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/

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Miguel Godinho Ferreira @miguelgf.bsky.social · May 28

Our latest preprint!
We show that telomeric antisense oligonucleotides alleviate premature #aging in #telomerase mutant #zebrafish. A collaboration with the labs of Fabrizio d'Adda di Fagagna and Marina Mione.
Congrats Bruno for his first corresponding author paper!👏
www.biorxiv.org/content/10.1...

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and ce...

www.biorxiv.org

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