irismarchal.bsky.social
Iris
@irismarchal.bsky.social
67 followers 54 following 12 posts
Associate Editor Reviews @Nature Biotechnology. Views are my own.
Posts Media Videos Starter Packs
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natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Aug 20
Redefining druggable targets with artificial intelligence - @wcmenglanderipm.bsky.social @aihealthmit.bsky.social go.nature.com/4fHNMYi
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Aug 6
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Engineering B cells to treat and study human disease - Nature Biotechnology
Recent developments in B cell engineering expand our ability to study human disease and drive progress toward new B cell therapies, balancing challenges in clinical implementation with emerging opport...
www.nature.com
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Reposted by Iris
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · Jul 6
Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Jul 2
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could help improve crops for more sustainable and climate-resilient agriculture. Read about it in this Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Unlocking gene regulatory networks for crop resilience and sustainable agriculture - Nature Biotechnology
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could advance crop improvement for more sustainable and climate-resilient agricultural practices.
www.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Jun 30
This Review presents a classification system of hybrid engineered biological systems to support researchers in making design choices, out now in @natbiotech.nature.com www.nature.com/articles/s41...
Improving engineered biological systems with electronics and microfluidics - Nature Biotechnology
A classification of hybrid engineered biological systems is presented to support researchers in making design choices that expand their use.
www.nature.com
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Reposted by Iris
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Jun 5
Base editors model mitochondrial disease #NBTNV - @mikrobenjaeger.bsky.social go.nature.com/45O9PJM
Base editors model mitochondrial disease - Nature Biotechnology
Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.
go.nature.com
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Reposted by Iris
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · May 29
Anatomy of the 23andMe fall and implications for consumer genomics go.nature.com/3Hf6sBE
Anatomy of the 23andMe fall and implications for consumer genomics - Nature Biotechnology
23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fal...
go.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · May 5
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications. Read how in this new Perspective in @natbiotech.nature.com www.nature.com/articles/s41...
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
www.nature.com
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Reposted by Iris
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Apr 28
A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR
A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology
Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools
go.nature.com
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tclavel.bsky.social
Thomas Clavel @tclavel.bsky.social · Apr 29
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
rdcu.be
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milolabwis.bsky.social
Milo Lab @WIS @milolabwis.bsky.social · Apr 23
1/ We need new ways of producing foods and fuels to minimise our impact on our planet. Our new paper now in
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Apr 17
The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic? @natbiotech.nature.com asked experts for an update. www.nature.com/articles/s41...
Cancer vaccines: the experts speak - Nature Biotechnology
The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in i...
www.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Apr 16
Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. @natbiotech.nature.com asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible www.nature.com/articles/s41...
Making cell therapy accessible: challenges and opportunities - Nature Biotechnology
Despite major advances in bringing cancer cell therapies to the clinic, their widespread accessibility remains a substantial challenge. High manufacturing costs, lack of funding and varying regulatory...
www.nature.com
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Reposted by Iris
kmpanthagani.bsky.social
Kristen Panthagani, MD, PhD @kmpanthagani.bsky.social · Apr 14
A look back at what vaccines have done.
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fertiglab.bsky.social
Elana Fertig, PhD @fertiglab.bsky.social · Apr 15
Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com
Virtual cells for predictive immunotherapy - Nature Biotechnology
Synergizing advances in artificial intelligence with mathematical modeling will improve our ability to computationally predict immunotherapy outcomes.
www.nature.com
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Reposted by Iris
rongl.bsky.social
Rong @rongl.bsky.social · Apr 15
This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Apr 14
Spotlight on cancer immunotherapies go.nature.com/3XUTPkM
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Apr 15
Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in @natbiotech.nature.com and don't forget to check out our full Focus Issue! www.nature.com/articles/s41...
Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology
The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...
www.nature.com
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Reposted by Iris
itaiyanai.bsky.social
Itai Yanai @itaiyanai.bsky.social · Apr 2
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
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Reposted by Iris
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Apr 1
Shares of US drugmakers fell after reports that @fda.gov top vaccine official, Peter Marks, had been forced to resign, as the Trump administration undertakes an overhaul of federal health agencies #NBTNewsBeat www.reuters.com/business/hea...
Pharma stocks sink after ouster of top FDA vaccine regulator
Shares of U.S. drugmakers fell on Monday after reports that the Food and Drug Administration's top vaccine official, Peter Marks, had been forced to resign, the most high-profile exit at the regulator as the Trump administration undertakes an overhaul of federal health agencies.
www.reuters.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Apr 2
Check out the state of the field of engineered bacteria for cancer therapy in this Comment in @naturebiotech.bsky.social www.nature.com/articles/s41...
The emerging landscape of engineered bacteria cancer therapies - Nature Biotechnology
Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...
www.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Mar 26
Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
www.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Mar 18
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
rdcu.be
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Feb 10
The program of the CiRT2025 meeting is out: meeting2025.cirt-net.org/program.html. I will be sharing my top 10 tips on publishing with @naturebiotech.bsky.social. See you there?
Program
meeting2025.cirt-net.org
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davidmartinez.bsky.social
David R. Martinez @davidmartinez.bsky.social · Dec 6
Our article is now out in Nature Biotechnology.

Here we outline challenges for developing broad-based mucosal vaccines for respiratory viruses. Check it out!

Congrats to Junghwa and Jordan from my lab and to other co-authors!

www.nature.com/articles/s41...
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
www.nature.com
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irismarchal.bsky.social
Iris @irismarchal.bsky.social · Dec 5
Natural and engineered Cas12 and TnpB variants offer diverse applications in genome editing and diagnostics - read all about it in this Review in @naturebiotech.bsky.social www.nature.com/articles/s41...
Biology and applications of CRISPR–Cas12 and transposon-associated homologs - Nature Biotechnology
Natural and engineered Cas12 and TnpB variants offer diverse applications in genome editing and diagnostics.
www.nature.com
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