Lightnews — Scholar-powered news

Indigo V.L. Rose @ivlrose.bsky.social · 4d

They’re lovely!

Reposted by Indigo V.L. Rose

Keri Martinowich @martinowk.bsky.social · 14d

In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.

www.bbc.com/news/article...

www.bbc.com/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.com

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Indigo V.L. Rose @ivlrose.bsky.social · 16d

We sure did! Jolted us awake here in central SF.

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Indigo V.L. Rose @ivlrose.bsky.social · 16d

Wow now that was an earthquake! Never been shaken awake before

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Reposted by Indigo V.L. Rose

Rob Patro @robp.bsky.social · 20d

Rust 1.90.0 is out! blog.rust-lang.org/2025/09/18/R...

Major features:
* lld as the default linker on x86_64-unknown-linux-gnu
* cargo workspace publishing support built into cargo
* more const context APIs, and stabilization of new useful APIs

Announcing Rust 1.90.0 | Rust Blog

Empowering everyone to build reliable and efficient software.

blog.rust-lang.org

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Reposted by Indigo V.L. Rose

Sarah Cohen @cohenlaboratory.bsky.social · 21d

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

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Reposted by Indigo V.L. Rose

Nadav Ahituv @nadavahituv.bsky.social · 21d

Most neurodevelopmental disorders are caused by having 1 functional gene copy. Using SCN2A, we show that upregulating the functional copy rescues neuronal phenotypes. Amazing work with @neurobender.bsky.social led by Serena Tamura, Andrew Nelson, Perry Spratt & others.
www.nature.com/articles/s41...

CRISPR activation for SCN2A-related neurodevelopmental disorders | Nature

www.nature.com

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Reposted by Indigo V.L. Rose

Waggoner Lab @labwaggoner.bsky.social · 27d

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling @cellcellpress.bsky.social @travisfaust.bsky.social
www.cell.com/cell/fulltex...

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Reposted by Indigo V.L. Rose

Randall Munroe @xkcd.com · 27d

Biology Department

xkcd.com/3140/

Comic. [Building with large sign in front of it[ SIGN: Welcome to the *Biology Department* It has been [changeable sign: 3] days since we discovered something existentially horrifying about bugs that makes you question your whole reality

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Reposted by Indigo V.L. Rose

Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · Sep 7

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

www.nytimes.com

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Indigo V.L. Rose @ivlrose.bsky.social · Sep 7

Getting a breathtaking view of the Golden Gate Bridge! Perfect conditions this weekend.

View of the Golden Gate Bridge out the front window of a small airplane on a sunny day

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Indigo V.L. Rose @ivlrose.bsky.social · Sep 5

Thanks Nat Neuro for posting about our recent paper! This project goes to show that you can have a really wacky idea and occasionally biology will throw you a bone and it will actually work!

Nature Neuroscience @natneuro.nature.com · Sep 5

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

@kampmann.bsky.social @ivlrose.bsky.social

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

www.nature.com

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Indigo V.L. Rose @ivlrose.bsky.social · Sep 4

I love this cover art so much!

Neuron @cp-neuron.bsky.social · Sep 3

We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:

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Reposted by Indigo V.L. Rose

The Transmitter @thetransmitter.bsky.social · Sep 3

Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/astrocytes/a...

Astrocyte networks span large swaths of brain

The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

www.thetransmitter.org

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Indigo V.L. Rose @ivlrose.bsky.social · Aug 23

Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research

Martin Kampmann @kampmann.bsky.social · Aug 22

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

www.nature.com

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Reposted by Indigo V.L. Rose

Andy Moore @aaandmoore.bsky.social · Aug 18

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

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Reposted by Indigo V.L. Rose

Dr. Krissy Lyon @krissylyon.bsky.social · Jul 29

Cool astrocyte paper!

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals - Nature Neuroscience

The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct lineage origins, we show that ...

www.nature.com

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Reposted by Indigo V.L. Rose

Jim Woodgett @jwoodgett.bsky.social · Jul 24

Good grief, the US National Cancer Institute projects it will fund only one in 25 RO1 grant applications in 2026. This is massively defunding cancer research. Despicable vandalism. www.cancer.gov/grants-train...

National Cancer Institute projection of a 4% pay line in FY2026.

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Reposted by Indigo V.L. Rose

Martin Kampmann @kampmann.bsky.social · Jul 23

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

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Reposted by Indigo V.L. Rose

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 22

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

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Reposted by Indigo V.L. Rose

Fillip Port @crisprflydesign.bsky.social · Jul 17

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.

www.nature.com/articles/s41...