Jenny Regan
@jennyregan.bsky.social
400 followers
500 following
3 posts
Biologist researching innate immunity across the life course in Drosophila 🪰 Macrophages | guts | infection | sex differences | ageing | intervention.
Senior Lecturer at the University of Edinburgh
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Jenny Regan
@jennyregan.bsky.social
· Jul 11
Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan
It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...
www.biorxiv.org
Reposted by Jenny Regan
Andreas Prokop
@poppi62.bsky.social
· Jul 2
Toward more sustainable research: reducing the environmental impact when working with Drosophila
Abstract. The ever-increasing amounts of plastic waste and greenhouse gas emissions worldwide threaten our environment. Biomedical laboratories across the
doi.org
Reposted by Jenny Regan
Philipp Brand
@pbrand.bsky.social
· Aug 21
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
www.biorxiv.org
Reposted by Jenny Regan
Kerri Kinghorn
@kinghornlab.bsky.social
· Aug 10
Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in Drosophila Models of Gaucher and Parkinson's Disease
Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinso...
www.biorxiv.org
Reposted by Jenny Regan
Reposted by Jenny Regan
Reposted by Jenny Regan
Joris Deelen
@jorisdeelen.bsky.social
· May 29
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants - GeroScience
Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-spe...
link.springer.com
Jenny Regan
@jennyregan.bsky.social
· Jul 11
Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan
It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...
www.biorxiv.org
Reposted by Jenny Regan
Helena Cocheme
@cochemelab.bsky.social
· Jun 27
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
Reposted by Jenny Regan
David Duneau
@dduneau.bsky.social
· Jun 6
A within-host infection model to explore tolerance and resistance
A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...
elifesciences.org
Reposted by Jenny Regan
Lesley Weaver
@lesleynweaver.bsky.social
· May 19
Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance
Adult tissue function is dependent on intrinsic factors that mediate stem cell self-renewal and proliferation in response to changes in physiology and…
www.sciencedirect.com
Reposted by Jenny Regan
Reposted by Jenny Regan
Reposted by Jenny Regan
Lesley Weaver
@lesleynweaver.bsky.social
· Jan 30
Estrogen-Related Receptor is Required in Adult Drosophila Females for Germline Stem Cell Maintenance
Stem cell self-renewal and proper tissue function rely on conserved metabolic regulators to balance energy production with inter-organ metabolic trafficking. The estrogen-related receptor (ERR) subfam...
www.biorxiv.org
Reposted by Jenny Regan
Nisha Philip
@nishaphilip.bsky.social
· Jan 31
A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito
Colonisation of the mosquito by the malarial parasite is critically reliant on the invasive ookinete stage. Ookinete invasion of mosquito is coordinated by the apical complex, a specialised parasite s...
www.biorxiv.org
Reposted by Jenny Regan
Reposted by Jenny Regan
Reposted by Jenny Regan
Ryusuke Niwa
@ryuniwa.bsky.social
· Jan 10
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster - Nature Communications
Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.
www.nature.com
Reposted by Jenny Regan
