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Reposted by Jim Stewart

Science News @scinews.bsky.social · Sep 7

Why would anyone want to be a scientist?

"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."

journals.biologists.com/jcs/article/...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · Aug 5

Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!

www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

www.embopress.org

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Jim Stewart @jim-ca.bsky.social · Jul 23

There's a live job ad for a Post-Grad or Post-doc level Bioinformatician position withing the Newcastle Mitohondrial Research Group @mitonewcastle.bsky.social, funded through the LifeArc Centre for Rare Mitochondrial Diseases

www.jobs.ac.uk/job/DNW541/r...

Research Associate (Bioinformatician) at Newcastle University

Apply for the Research Associate (Bioinformatician) role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

www.jobs.ac.uk

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Jim Stewart @jim-ca.bsky.social · Jul 17

8 healthy babies after Mitochondrial Donation treatment - Press Office - Newcastle University share.google/iaZoEyfgHHd9...

Eight babies born after Mitochondrial donation

The UK’s pioneering licensed IVF technique to reduce the risk of mitochondrial diseases carried out in Newcastle has seen eight babies born, published research shows.

share.google

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Eric Topol @erictopol.bsky.social · Jul 17

A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

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Michal Minczuk @mitogene.bsky.social · Jul 2

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

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Newcastle Mitochondrial Research Group @mitonewcastle.bsky.social · Jun 26

📢 Exciting 3-year funded PhD opportunity 🧠
Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group.

📅 Closing date: 16th July 2025
⏰ Start date: 15th September 2025
To apply: www.findaphd.com/phds/project...

PhD studentship - Understanding the causes and identifying treatments for Alpers’ syndrome at Newcastle University on FindAPhD.com

PhD Project - PhD studentship - Understanding the causes and identifying treatments for Alpers’ syndrome at Newcastle University, listed on FindAPhD.com

www.findaphd.com

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Selene FeRNAndez @selfdz.bsky.social · Jun 26

Yesterday, @carlbergstrom.com presented his course "Modern-day Oracles or BS Machines? How to thrive in a ChatGPT world". Neat way to make students aware of the capacities and limitations of LLMs👇🎰

Recording: www.youtube.com/watch?v=TZC0...

Course: thebullshitmachines.com

@unswbabs.bsky.social

Modern Day Oracles or Bullshit Machines? Seminar with Prof. Carl Bergstrom, University of Washington

YouTube video by UNSW eLearning

www.youtube.com

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Newcastle Mitochondrial Research Group @mitonewcastle.bsky.social · May 14

We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease

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Jim Stewart @jim-ca.bsky.social · May 23

Congratulations Rob!!! @taylorlabncl.bsky.social

www.ncl.ac.uk/press/articl...

Prestigious academy elects leading scientists to its Fellowship

The Academy of Medical Sciences has elected two prominent Newcastle University academics to its Fellowship.

www.ncl.ac.uk

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The Lily Foundation @lilyfoundation.bsky.social · May 22

Meet the minds behind the LifeArc Centre for Rare Mitochondrial Diseases

Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters

www.thelilyfoundation.org.uk/affected-by-...

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Natalie Niemi @nieminm.bsky.social · May 15

Perfect title to this article: “When everything is a master regulator, nothing is”

American Society for Cell Biology @ascbiology.bsky.social · May 15

From MBoC
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology

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Joanna Elson @joannaelson.bsky.social · May 14

I was connected by a writer from The Scientist magazine who was interested in some of my work. Here is what they wrote:

www.the-scientist.com/mitochondria...

Mitochondrial DNA: A Maternal Legacy That Helps Trace the Past and Diagnose the Future

The mitochondrial genome can help researchers map ancestry and better understand the inheritance of mitochondrial diseases.

www.the-scientist.com

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Reposted by Jim Stewart

Taylor Lab @taylorlabncl.bsky.social · May 14

@newcastleuni.bsky.social @nihrnewcastlebrc.bsky.social @medicalsciencesncl.bsky.social @neygenomics.bsky.social

Newcastle Mitochondrial Research Group @mitonewcastle.bsky.social · May 14

We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease

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Newcastle Mitochondrial Research Group @mitonewcastle.bsky.social · May 14

What to find the Bluesky acount for one of our researchers? Here' a handy-dandy starter pack for you.

go.bsky.app/98NSnmp

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The Lily Foundation @lilyfoundation.bsky.social · May 14

We’re proud that the @lifearc.bsky.social Centre for Rare Mitochondrial Diseases has officially launched at a prestigious House of Lords event – a significant milestone in transforming the UK’s rare disease research landscape

Stay tuned to meet the lead minds behind the centre on our Research Zone!

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Mike DiGirolamo @mikedigirolamo.bsky.social · May 6

"I think that the word is being misused. Extinction's forever. It's irreversible...I think it's a really dangerous precedent to claim we can fix some of these irreversible problems," @dieterhochuli.bsky.social says on the podcast.

The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'

‘De-extinction’ isn’t just misleading — it’s dangerous, ecologist says

A biotech company in the United States made headlines last month by revealing photos of genetically modified gray wolves, calling them “dire wolves,” a species that hasn’t existed for more than 10,000...

news.mongabay.com

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Juleen R. Zierath @juleenrzierath.bsky.social · Apr 30

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

www.sciencedirect.com

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Eric Topol @erictopol.bsky.social · Apr 27

The de-extinction of the dire wolves?
"Colossal Baloney"— @stemcells.bsky.social
www.latimes.com/business/sto...
@latimes.com by @hiltzikm.bsky.social

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dbogani.bsky.social @dbogani.bsky.social · Apr 25

Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...

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Paulina Wanrooij @paulinawanrooij.bsky.social · Apr 22

Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Michal Minczuk @mitogene.bsky.social · Apr 12

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

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Sam Lewis, Ph.D. @samlewis.bsky.social · Apr 18

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress

Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.

www.science.org

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Sjoerd Wanrooij @wanrooij20.bsky.social · Apr 17

Good science from Josefin Forslund and our team:
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Jim Stewart

Taylor Lab @taylorlabncl.bsky.social · Apr 15

Such a great day and opportunity to work together as a UK mitochondrial research community going forward!

@mitonewcastle.bsky.social @drperscitus.bsky.social @sarahjpickett.bsky.social @mtrost.bsky.social @jim-ca.bsky.social @newcastleuni.bsky.social @medicalsciencesncl.bsky.social

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Apr 15

It was a great day and a fantastic #PPIE workshop!! @lifearc.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @dwong47.bsky.social @mitogene.bsky.social @mrc-mbu.bsky.social @mitonewcastle.bsky.social @uclqsion.bsky.social

The Lily Foundation @lilyfoundation.bsky.social · Apr 15

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research

We led a workshop on making complex science clear – because involving patients is key to success

#mitochondrialdisease #mitoresearch #patientvoice #raredisease

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