Jim Rybarski
@jimrybarski.bsky.social
what fresh hell is this
February 1, 2026 at 4:47 PM
what fresh hell is this
Reposted by Jim Rybarski
i think this MLK day the thing to focus on is the strategic focus and tactical brilliance of the civil rights movement and the way it was laser focused on a set of achievable goals
January 19, 2026 at 3:05 PM
i think this MLK day the thing to focus on is the strategic focus and tactical brilliance of the civil rights movement and the way it was laser focused on a set of achievable goals
Reposted by Jim Rybarski
It’s 2026, still no Armata, but cutting edge warfare brought a horse with Starlink instead
January 8, 2026 at 7:26 AM
It’s 2026, still no Armata, but cutting edge warfare brought a horse with Starlink instead
Definitely not making a Frankenstein
December 30, 2025 at 7:17 PM
Definitely not making a Frankenstein
Reposted by Jim Rybarski
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Reposted by Jim Rybarski
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
Reposted by Jim Rybarski
If anyone needs me I will be in the museum, lying down next to the bog bodies.
October 13, 2025 at 5:58 PM
If anyone needs me I will be in the museum, lying down next to the bog bodies.
Reposted by Jim Rybarski
Odd to consider, but T-Rex had a Krebs cycle
October 11, 2025 at 5:16 PM
Odd to consider, but T-Rex had a Krebs cycle
Reposted by Jim Rybarski
As I tell my students, if you arrived at a simple answer in biology you have done one of two things: arrived at the wrong answer or asked the wrong question
Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
October 9, 2025 at 2:38 PM
As I tell my students, if you arrived at a simple answer in biology you have done one of two things: arrived at the wrong answer or asked the wrong question
Reposted by Jim Rybarski
Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
October 7, 2025 at 4:11 PM
Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com/p/we-still-c...
Reposted by Jim Rybarski
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
www.nature.com
September 21, 2025 at 8:06 AM
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
📄 www.nature.com/articles/s41...
💿 mmseqs.com
Reposted by Jim Rybarski
New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...
lh3.github.io/2025/09/11/a...
September 12, 2025 at 3:26 AM
New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...
lh3.github.io/2025/09/11/a...
Reposted by Jim Rybarski
"PhD-level experts in your back pocket" is a completely nonsensical description of AI but a pretty good description of social media if you follow the right people
August 9, 2025 at 11:07 PM
"PhD-level experts in your back pocket" is a completely nonsensical description of AI but a pretty good description of social media if you follow the right people
Reposted by Jim Rybarski
A simple rule for better public speaking: If you’re using slides that contain text, you must read it out, word-for-word.
clauswilke.substack.com/p/read-out-a...
clauswilke.substack.com/p/read-out-a...
Read out all of the text on your slides
I have a simple rule for better public speaking: If you’re using slides that contain text, you must read it out, word-for-word.
clauswilke.substack.com
July 20, 2025 at 3:58 PM
A simple rule for better public speaking: If you’re using slides that contain text, you must read it out, word-for-word.
clauswilke.substack.com/p/read-out-a...
clauswilke.substack.com/p/read-out-a...
Reposted by Jim Rybarski
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
July 7, 2025 at 8:21 AM
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
Reposted by Jim Rybarski
These NPG spinoff journals are out of control
June 29, 2025 at 4:50 PM
These NPG spinoff journals are out of control
Reposted by Jim Rybarski
Correct. People who say otherwise either don't understand the numbers, or are engaging in wishful thinking.
The brain drain will be when scientists are forced into other careers/jobs so that they can keep paying the bills. They will never return.
There aren't enough science jobs in other countries to absorb even a fraction of those laid off.
There aren't enough science jobs in other countries to absorb even a fraction of those laid off.
On a basic level- you can't expect US talent to sit on their hands and wait until maybe, hopefully there's a job for them. A handful might be able to do that, but the majority are going to leave. Countries are actively seeking to take advantage of US brain drain.
June 4, 2025 at 1:41 AM
Correct. People who say otherwise either don't understand the numbers, or are engaging in wishful thinking.
Reposted by Jim Rybarski
It's really important that what's happening at Harvard is not covered just as research cuts but as an all-out assault on higher education. This administration has explicitly said their goal is to destroy, or at the very least dramatically reshape, these institutions.
May 16, 2025 at 9:05 PM
It's really important that what's happening at Harvard is not covered just as research cuts but as an all-out assault on higher education. This administration has explicitly said their goal is to destroy, or at the very least dramatically reshape, these institutions.
Reposted by Jim Rybarski
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Reposted by Jim Rybarski
Absolutely not an exaggeration. High crimes and misdemeanors committed and endorsed in the Oval Office on live television.
The president is conducting a press event with the primary purpose of flouting the decisions of the courts and the letter and spirit of U.S. law. It is a press event to celebrate the Constitutional crisis and serial violation of human rights he has set in motion.
COLLINS: Can President Bukele weigh in on this? Do you plan to return Garcia?
BUKELE: How can I smuggle a terrorist into the United States? Of course I'm not going to do it. The question is preposterous
TRUMP: These are sick people
BUKELE: How can I smuggle a terrorist into the United States? Of course I'm not going to do it. The question is preposterous
TRUMP: These are sick people
April 14, 2025 at 4:18 PM
Absolutely not an exaggeration. High crimes and misdemeanors committed and endorsed in the Oval Office on live television.
Reposted by Jim Rybarski
Hi. I’m an expert in modernizing legacy government software systems. This is profoundly stupid and will definitely fail, and it’s just a question of whether our social security system fails along with it.
SCOOP: DOGE wants to rebuild SSA's codebase in months, risking benefits and system collapse, sources tell me.
The plan is to migrate all systems off COBOL quickly which would likely require the use of generative AI.
www.wired.com/story/doge-r...
The plan is to migrate all systems off COBOL quickly which would likely require the use of generative AI.
www.wired.com/story/doge-r...
DOGE Plans to Rebuild SSA Codebase In Months, Risking Benefits and System Collapse
Social Security systems contain tens of millions of lines of code written in COBOL, an archaic programming language. Safely rewriting that code would take years—DOGE wants it done in months.
www.wired.com
March 28, 2025 at 2:54 PM
Hi. I’m an expert in modernizing legacy government software systems. This is profoundly stupid and will definitely fail, and it’s just a question of whether our social security system fails along with it.
Reposted by Jim Rybarski
They are just disappearing people off the street. Having a hard time thinking about literally anything else.
Not sure if this has been shared here yet, but this is video of Rumeysa Ozturk's arrest posted by WCVB. It's terrifying.
March 27, 2025 at 5:15 AM
They are just disappearing people off the street. Having a hard time thinking about literally anything else.
Reposted by Jim Rybarski
We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
March 27, 2025 at 2:19 PM
We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Jim Rybarski
Watch Firefly land on the Moon! After identifying surface hazards and selecting a safe landing site, #BlueGhost landed directly over the target in Mare Crisium. A historic moment on March 2 we'll never forget. We have Moon dust on our boots! #BGM1
youtu.be/NpHhEybJdxg
youtu.be/NpHhEybJdxg
Moon Landing - Firefly Blue Ghost Makes History
YouTube video by Firefly Aerospace
youtu.be
March 4, 2025 at 6:56 PM
Watch Firefly land on the Moon! After identifying surface hazards and selecting a safe landing site, #BlueGhost landed directly over the target in Mare Crisium. A historic moment on March 2 we'll never forget. We have Moon dust on our boots! #BGM1
youtu.be/NpHhEybJdxg
youtu.be/NpHhEybJdxg