Lightnews — Scholar-powered news

Reposted by Johanna Ivaska

EMBO Reports @emboreports.org · Sep 9

The first September issue is live.

www.embopress.org/toc/14693178...

The cover features work by Cassie Clarke @cassiejclarke.bsky.social @cruk-si.bsky.social and co-workers showing that UPP1 supports #metastasis by altering #immune and ECM landscapes.

-> www.embopress.org/doi/full/10....

6 9

Johanna Ivaska @johannaivaska.bsky.social · Jul 16

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

www.sciencedirect.com

1 15 35

Reposted by Johanna Ivaska

InFLAMES Research Flagship @inflames-flagship.bsky.social · Jun 3

Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa - InFLAMES-lippulaiva

Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää. Menetelmä on paljastunut, että muihin syöpätyyppeihin parha...

inflames.utu.fi

3 3

Reposted by Johanna Ivaska

Tom Van Agtmael @tomvanagtmael.bsky.social · May 30

New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells
rdcu.be/eoAUD

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells

Nature Cell Biology - Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST...

rdcu.be

1 9

Reposted by Johanna Ivaska

Turun yliopisto - University of Turku @utu.fi · Jun 2

Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.

@ivaskalab.bsky.social @johannaivaska.bsky.social

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa

Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää.

www.utu.fi

3 11

Reposted by Johanna Ivaska

James Conway @jrwconway.bsky.social · Feb 12

Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025

1 3

Reposted by Johanna Ivaska

James Conway @jrwconway.bsky.social · May 26

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

1 15 29

Reposted by Johanna Ivaska

Ivaska Lab @ivaskalab.bsky.social · May 26

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

10 40

Johanna Ivaska @johannaivaska.bsky.social · May 26

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!

Read more at:

www.nature.com/articles/s41...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology

Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

www.nature.com

9 32

Johanna Ivaska @johannaivaska.bsky.social · May 21

Thanks for letting me participate! It was fun

1

Johanna Ivaska @johannaivaska.bsky.social · May 20

www.is.fi/kotimaa/art-...

Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years

Syöpätutkija Johanna Ivaskalle 100 000 euron tiedepalkinto

Ivaskan työryhmä tutkii syöpäsolujen liikkumista ja leviämistä.

www.is.fi

2 2 28

Reposted by Johanna Ivaska

InFLAMES Research Flagship @inflames-flagship.bsky.social · May 20

Warm congratulations to our PI, Professor Johanna Ivaska👏💐🍾🎉🔥🔥🔥!
@johannaivaska.bsky.social @ivaskalab.bsky.social

Finnish Science Award to Professor Johanna Ivaska

The Finnish Science Award 2025 has been awarded to Johanna Ivaska, Professor of Molecular Cell Biology at the University of Turku.

www.utu.fi

2 29

Johanna Ivaska @johannaivaska.bsky.social · May 20

yle.fi/a/74-20162747

Syöpätutkija Johanna Ivaska palkittiin 100 000 eurolla – ”Levinnyt syöpä on edelleen suuri haaste”

Palkittu syöpätutkija kritisoi hallituksen säästöjä, jotka kohdistuvat yliopistojen perustutkimukseen.

yle.fi

5

Johanna Ivaska @johannaivaska.bsky.social · May 20

Proud to have you in my team

1

Reposted by Johanna Ivaska

Riitta Monto @riittamonto.bsky.social · May 20

Paljon onnea Suomen tiedepalkinnosta, @johannaivaska.bsky.social
Professorin viesti päättäjille: "Minä toivoisin, että Suomen valtiovalta ja poliitikot ymmärtäisivät, että pienessä maassa perustutkimus on se ainoa tapa, millä niitä paljon puhuttuja innovaatioita saadaan."
www.ts.fi/uutiset/6665...

Suomen tiedepalkinto turkulaiselle syöpätutkijalle

Professori Johanna Ivaska pitää syöpää erityisen kiehtovana tutkimuskohteena ja innostuu siitä yhä uudelleen.

www.ts.fi

2 16

Johanna Ivaska @johannaivaska.bsky.social · May 20

Kiitos

1

Reposted by Johanna Ivaska

Mari Riipinen @maririipinen.bsky.social · May 20

Tiedefoorumissa puhetta tieteestä. Onnittelut @johannaivaska.bsky.social Suomen tiedepalkinnosta.

1 1 4

Johanna Ivaska @johannaivaska.bsky.social · May 20

Thanks this prize is really not for me but the @ivaskalab.bsky.social and all your hard work and brilliant brains

3

Reposted by Johanna Ivaska

Helen Matthews @helenkmatthews.bsky.social · May 1

Happy to publish this News & Views article highlighting exciting new work from Rod Bremner's lab that shows that cell populations with a short cell cycle are intrinsically more susceptible to forming tumours

Barbara Marte @barbmarte.bsky.social · May 1

and the News & Views www.nature.com/articles/d41...

The cell-division cycle is faster in cell types prone to forming cancer

Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.

www.nature.com

1 7 10

Reposted by Johanna Ivaska

eLife @elife.bsky.social · Mar 23

Using #CRISPR/Cas9 to genetically modify cells to produce extracellular matrices with altered compositions.
elifesciences.org/reviewed-pre...

orange and cyan microscopy image of cartilage tissues

4 16

Reposted by Johanna Ivaska

Michal Dibus @midibu.bsky.social · May 9

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

www.biorxiv.org

3 18 29

Reposted by Johanna Ivaska

Sam Aytekin @samaytekin.bsky.social · May 2

We did it!
🧪 After years of fiddling with gels, lasers, cells, and infinite lines of custom codes, our first preprint is out!
We integrated TFM & FRET-based tension probes into one workflow to zoom in on focal adhesions mechanics 🔬
Already 400 downloads and I’m only mildly panicking 😅

Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics

Focal adhesions (FAs) are mechanosensitive structures that mediate force transmission between cells and the extracellular matrix. While Traction Force Microscopy (TFM) quantifies cellular tractions ex...

www.biorxiv.org

2 4 18

Johanna Ivaska @johannaivaska.bsky.social · May 16

@midibu.bsky.social uncovers a FUNCTIONAL role for Tensin- 1 condensates acting as reservoirs of inactive focal adhesion proteins under the control of p38, ERK and AKT kinase activity. Protein-release from TNS1 condensates facilitate adhesion dynamics, filopodia, cell migration and cell invasion

Ivaska Lab @ivaskalab.bsky.social · May 10

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

www.biorxiv.org

6

Johanna Ivaska @johannaivaska.bsky.social · May 8

Thanks for an amazing meeting GRC Fibronectin, integrins and related molecules @sarawickstrom.bsky.social and Guy

2 28

Johanna Ivaska @johannaivaska.bsky.social · May 8

Well done GRS chairs Martina and @mchastney.bsky.social

7