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Reposted by Ivaska Lab

Karolinska Institutet @ki.se · Aug 18

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

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Reposted by Ivaska Lab

Pieta Mattila @mattilalab.bsky.social · Aug 12

Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!

Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩

Adapting an amazing tool from @ivaskalab.bsky.social 💥

Blanca Tejeda @blancatejgon.bsky.social · Aug 12

I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)!
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...

Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation

B cell activation by foreign antigens, recognized by the B cell receptor (BCR), is the key prerequisite for cell differentiation for antibody production. B cells typically encounter antigens bound to ...

www.biorxiv.org

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Ivaska Lab @ivaskalab.bsky.social · Jul 16

Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes!

Congratulations to all the authors!

Check the paper out here: www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

www.sciencedirect.com

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Reposted by Ivaska Lab

Johanna Ivaska @johannaivaska.bsky.social · Jul 16

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

www.sciencedirect.com

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Reposted by Ivaska Lab

Michal Dibus @midibu.bsky.social · Jul 7

If you are at the FEBS Congress in Istanbul and would like to have a chat about adhesion-derived protein condensates come to see my poster today between 12:30-13:45. Looking forward to inspiring discussions! 🔬

@ivaskalab.bsky.social

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Reposted by Ivaska Lab

Guillaume Jacquemet @guijacquemet.bsky.social · Jun 23

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

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Reposted by Ivaska Lab

Claus Jorgensen @clausjorgensen.bsky.social · Jun 7

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute

Add brief description here

www.cruk.manchester.ac.uk

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Michalis Gounis @gounismichalis.bsky.social · Jun 9

1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

Journal of Cell Biology @jcb.org · Jun 9

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

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Reposted by Ivaska Lab

Turun yliopisto - University of Turku @utu.fi · Jun 2

Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen.

@ivaskalab.bsky.social @johannaivaska.bsky.social

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa

Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää.

www.utu.fi

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Reposted by Ivaska Lab

Turun yliopisto - University of Turku @utu.fi · Jun 2

Signaling networks inside #cancer cells control everything from growth to movement, but visualising this in living cells requires new and refined methods. Researcher James Conway set out to see these invisible signals and came up with a new tool to do just that.
#Illusia
@ivaskalab.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination

Cancer cell movement during metastasis is a dynamic process regulated by several different signals.

www.utu.fi

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Reposted by Ivaska Lab

InFLAMES Research Flagship @inflames-flagship.bsky.social · Jun 3

Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle.
#Illusia
@johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social

Uusi koetin tekee näkyväksi syöpäsolun viestinnän, tutkijat voivat käyttää tietoa rintasyövän leviämisen estossa - InFLAMES-lippulaiva

Turun yliopistossa ja Turun biotiedekeskuksessa toimiva tutkimusryhmä on kehittänyt tavan kuvata leviävien rintasyöpäsolujen soluviestintää. Menetelmä on paljastunut, että muihin syöpätyyppeihin parha...

inflames.utu.fi

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Reposted by Ivaska Lab

InFLAMES Research Flagship @inflames-flagship.bsky.social · Jun 3

In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread.
#Illusia
@ivaskalab.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination - InFLAMES Research Flagship

Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to dete...

inflames.utu.fi

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Reposted by Ivaska Lab

James Conway @jrwconway.bsky.social · May 26

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

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Reposted by Ivaska Lab

Johanna Ivaska @johannaivaska.bsky.social · May 26

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!

Read more at:

www.nature.com/articles/s41...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology

Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

www.nature.com

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Ivaska Lab @ivaskalab.bsky.social · May 26

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

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Reposted by Ivaska Lab

Johanna Ivaska @johannaivaska.bsky.social · May 20

www.is.fi/kotimaa/art-...

Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize
thanks to all my international friends and colleagues over the years

Syöpätutkija Johanna Ivaskalle 100 000 euron tiedepalkinto

Ivaskan työryhmä tutkii syöpäsolujen liikkumista ja leviämistä.

www.is.fi

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Ivaska Lab @ivaskalab.bsky.social · May 20

We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!

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Reposted by Ivaska Lab

Naba Lab UIC @nabalabuic.bsky.social · May 12

Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!

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Ivaska Lab @ivaskalab.bsky.social · May 10

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

www.biorxiv.org

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Reposted by Ivaska Lab

Michal Dibus @midibu.bsky.social · May 9

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

www.biorxiv.org

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Reposted by Ivaska Lab

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Reposted by Ivaska Lab

@Westermarcklab @westermarcklab.bsky.social · May 8

Very important milestone for Finnish academic drug development. The recently established Finnish Drug Development Center has started its first drug development project in collaboration with a start-up Kohde Pharma. ddcenter.fi/kohde-pharma...

Kohde Pharma Oy Secures Investment from Finnish Drug Discovery Center Ltd - Finnish Drug Discovery Center

Vantaa, Finland – May 8th 2025 – Kohde Pharma Oy, a newly incorporated pharmaceutical company in Finland, is pleased to announce that it has secured its first investment from Finnish Drug Discovery Ce...

ddcenter.fi

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Reposted by Ivaska Lab

Paulina Morlay @drpaulinamoreno.bsky.social · May 7

On my way home after 3 days full of great talks and lively discussions at Fort-Mahon-Plage. Thank you @clubexo-endo.bsky.social community, I had a blast!

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Reposted by Ivaska Lab

Omkar Joshi @omkarjoshi.bsky.social · May 7

I'm at the Fibronectin GRC till the end of the week! Come say hi and I'll tell you a bit about mitochondrial near focal adhesions😉

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Reposted by Ivaska Lab

Michal Dibus @midibu.bsky.social · May 7

Currently at Fibronectin and Integrins GRC in Italy, meeting amazing people and discussing great science. If you are interested in Tensin phase separation, come and talk to me!
@ivaskalab.bsky.social

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