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Paulina Morlay

@drpaulinamoreno.bsky.social

190 followers 260 following 5 posts

Researcher working on integrin traffic and cancer biology @ Turku Centre for Biotechnology, University of Turku. All opinions are my own

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Paulina Morlay @drpaulinamoreno.bsky.social · Jul 16

Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

bit.ly

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Reposted by Paulina Morlay

Joachim Goedhart @joachimgoedhart.bsky.social · 14d

Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents by Oliver Thorn-Seshold and team: www.biorxiv.org/content/10.1...

Graphical abstract, showing the principles of conditional labeling with HaloTag

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Maik Bischoff @maikbischoff.bsky.social · 14d

1/12 A very special moment for me! 🎉

My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.

rupress.org/jcb/article/...

#cellbio #devbio #science

🧵for details

Cartoon of a speculative heterogenous cell population performing mesenchymal collective cell migration.

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Robert Grosse @ grosselab @grosselab.bsky.social · 16d

we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 19d

A cell finding its way through the matrix, imaged with @joycemeiri.bsky.social on LLS.

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Christophe 🔬 L @christlet.bsky.social · 21d

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

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BioCity Turku @biocityturku.bsky.social · 20d

Autumn 2025 Frontiers of Science talks have started today, and such a great talk we heard from Prof. Hiroki Ueda telling us why do we sleep. The auditorium was full packed!

@inflames-flagship.bsky.social @turkubioscience.bsky.social @utu.fi @dianalehotina.bsky.social

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Eric Topol @erictopol.bsky.social · 24d

I've been following the field of biosensors for nearly 2 decades. This may well turn out to be the most important advance yet
erictopol.substack.com/p/biosensors...

Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

A recording from Eric Topol's live video

erictopol.substack.com

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Jon Humphries @jdhl18.bsky.social · 27d

Basement membranes at a glance
journals.biologists.com/jcs/article/...

Basement membranes at a glance

Summary: Basement membranes (BMs) are dynamic assemblies of secreted proteins uniquely tailored for diverse tissue supporting roles. Here, we review our current understanding of BM composition, format...

journals.biologists.com

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Benoit Ladoux @bladoux.bsky.social · Sep 4

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions | Science Advances www.science.org/doi/10.1126/...

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions

This work demonstrates that changes in the nonlinear elasticity of collagen in hybrid networks tunes cell-matrix interactions.

www.science.org

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Reposted by Paulina Morlay

Carmelo Ferrai @carmeloferrai.bsky.social · Sep 9

From the lab of @sarawickstrom.bsky.social

Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier

journals.biologists.com/jcs/article/...

Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier

Highlighted Article: Piezo1 regulates timely maturation of cell–cell junctions into tight junction belts in epidermal keratinocytes through balancing of cortical and membrane tension; this is required...

journals.biologists.com

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Erdinc Sezgin @sciezgin.bsky.social · Sep 8

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · Aug 28

A new #UExM probe for #Actin!

Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social !

Congrats to all !

If interested in #UExM, or #HAK-Actin, feel free to reach out !

Soon available at @spirochrome.com

#Expansion #Microscopy #ProtistsOnSky

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Aug 28

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

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@Westermarcklab @westermarcklab.bsky.social · Aug 28

Elias Tillandz Prize awarded at the BioCity Symposium to scientific publications on breast cancer recurrence and cancer gene overactivation www.utu.fi/en/news/pres...

Elias Tillandz Prize awarded at the BioCity Symposium to scientific publications on breast cancer recurrence and cancer gene overactivation

The Elias Tillandz prize for the best scientific publication of 2024 was presented for two groundbreaking cancer studies.

www.utu.fi

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Science News @scinews.bsky.social · Aug 28

Repeated heatwaves can age you as much as smoking or drinking

"Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing."

www.nature.com/articles/s41...

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Aug 21

A fascinating paper! I think in hindsight, us scientists are all expecting this to happen when we knockout something. But to actually characterise its effects and see it happening in real time is still eye opening. Watch out for Transcriptional Adaptation!

Griffiths Lab @griffithslab.bsky.social · Aug 4

If you find a difference in phenotype between knockout and inhibitor/knockdown, transcriptional adaptation may be the culprit. This remarkable phenomenon demonstrates the robustness & complexity of cells, but can hamper CRISPR-based investigations if you aren't aware of it!

doi.org/10.1242/jcs....

Transcriptional adaptation after deletion of Cdc42 in primary T cells

Highlighted Article: CRISPR/Cas9-mediated deletion of Cdc42 in primary T cells triggers transcriptional adaptation, leading to enhanced T cell function. Chemical inhibition with CASIN is highly specif...

doi.org

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Lucien Hinderling @lhinderling.bsky.social · Aug 21

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

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Cell Biology J-Club @cellclub.bsky.social · Jul 31

www.nature.com/articles/s41...

Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation - Nature Communications

The endosomal retrieval subdomain organizes recycling of endocytosed proteins. Here, using proximity proteomics, the authors reveal that this recycling subdomain regulates switching of specific RAB GT...

www.nature.com

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Mike Lacy @mlacyphd.bsky.social · Jul 29

💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback."
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)

When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells

Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.

blog.addgene.org

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Dr. Jonathan N. Stea @jonathanstea.bsky.social · Jul 30

It has taken medical science 200 years to advance humans to the point where people are so healthy and living so long that they can deny that science and medicine is what got us here.

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Nature Portfolio @natureportfolio.nature.com · Jul 29

A paper in Nature Neuroscience suggests that the brain detects when a potential source of infection enters the immediate surroundings and prepares the body’s immune defenses. This may occur even before physical contact is made, in a virtual reality environment. go.nature.com/45cCSF7 #medsky 🧪

This is figure 1, which shows early detection of infectious avatars by the PPS system.

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MOREL Lab / MEMBRAMICS research @membramics-lab.bsky.social · Jul 24

Endosome–ER contact sites in phagophore formation: Trends in Cell Biology www.cell.com/trends/cell-...

Check out the recent spotlight published in @cp-trendscellbio.bsky.social about our study on ER-endosome contacts in autophagy by @julianedagraca.bsky.social

Endosome–ER contact sites in phagophore formation

Autophagy is a crucial ‘self-eating’ mechanism used by eukaryotic cells to degrade and recycle cytosolic materials. A recent study by Da Graça et al. reports that the dynamic mobilization of endosome–...

www.cell.com

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Joseph Hetmanski @mankie06.bsky.social · Jul 14

Pleased that our latest paper is now out in @jcellsci.bsky.social, in collaboration with @drmcjones.bsky.social and others from Manchester and Plymouth: Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...