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Reposted by Jorge Lázaro

Parc de Recerca Biomèdica de Barcelona @prbb.org · 5d

🎙️En motiu del #DiaMundialDelsAnimals, al #PRBBPodcast #LaMareDeLaCiència parlem amb @jorgelazaro.bsky.social d' @embl.org, que ha creat un petit zoo de cèl·lules mare 🧬 per entendre com es desenvolupen els embrions en diferents espècies… inclosos els humans!

🎧Escolta’l aquí 👉https://tuit.cat/y31xe

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Reposted by Jorge Lázaro

Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 6d

Finally .. incredible much awaited wok on deriving avian naive ESCs

“Derivation of embryonic stem cells across avian species”

www.nature.com/articles/s41...

Derivation of embryonic stem cells across avian species - Nature Biotechnology

Embryonic stem cells for chicken and seven other avian species are derived.

www.nature.com

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Reposted by Jorge Lázaro

Ina Sonnen @sonnenlab.bsky.social · 29d

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

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Jorge Lázaro @jorgelazaro.bsky.social · May 21

I'm happy to share that I recently started a postdoctoral position in the labs of @lab-turner.bsky.social and @jamesbriscoe.bsky.social at the Francis Crick Institute. Stay tuned for some marsupial development!

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Reposted by Jorge Lázaro

Development @dev-journal.bsky.social · Apr 23

In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling

Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....

In preprints: a new preprint curation initiative from Development

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Reposted by Jorge Lázaro

Miki Ebisuya @ebisuyamiki.bsky.social · Apr 17

Jorge and I wrote an introductory article highlighting two HOT new preprints on the segmentation clock!

Jorge Lázaro @jorgelazaro.bsky.social · Apr 17

In this "In preprints" piece, we highlight recent work from the @sonnenlab.bsky.social and Kageyama labs exploring novel mechanisms and tools involved in cell- and tissue-level couplings during somitogenesis. Congrats to the authors! @dev-journal.bsky.social

doi.org/10.1242/dev....

In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling

The segmented body plan of vertebrates becomes apparent during development, when two bilaterally symmetrical rows of somites emerge along the body axis. This process, known as somitogenesis, occurs se...

doi.org

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Jorge Lázaro @jorgelazaro.bsky.social · Apr 17

In this "In preprints" piece, we highlight recent work from the @sonnenlab.bsky.social and Kageyama labs exploring novel mechanisms and tools involved in cell- and tissue-level couplings during somitogenesis. Congrats to the authors! @dev-journal.bsky.social

doi.org/10.1242/dev....

In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling

The segmented body plan of vertebrates becomes apparent during development, when two bilaterally symmetrical rows of somites emerge along the body axis. This process, known as somitogenesis, occurs se...

doi.org

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Reposted by Jorge Lázaro

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Mar 20

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

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Jorge Lázaro @jorgelazaro.bsky.social · Apr 4

Congratulations!!

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Jorge Lázaro @jorgelazaro.bsky.social · Apr 1

Great opportunity and amazing mentor. Do not think twice!

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Apr 1

We’re looking for PhD students to join the lab! 🧫🧑‍🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/

‼️Deadline: April 15‼️

PhD Program

Empowering Curious Researchers at the Vienna BioCenter PhD Program Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter P...

training.vbc.ac.at

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Reposted by Jorge Lázaro

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Apr 1

We’re looking for PhD students to join the lab! 🧫🧑‍🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/

‼️Deadline: April 15‼️

PhD Program

Empowering Curious Researchers at the Vienna BioCenter PhD Program Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter P...

training.vbc.ac.at

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Jorge Lázaro @jorgelazaro.bsky.social · Mar 25

Thank you for this extensive review! I really enjoyed reading it.

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James Hammond @jamesehammond.bsky.social · Mar 24

Latest work:

Review on the evolvability of vertebral number, and the developmental processes underpinning it

Written by Callum Bucklow, @bertaverd.bsky.social, and myself

Check it out here: doi.org/10.32942/X2K...

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Reposted by Jorge Lázaro

Institute of Molecular Biotechnology @imbavienna.bsky.social · Mar 5

Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!

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Jorge Lázaro @jorgelazaro.bsky.social · Mar 5

Incredible news! Congrats Kristina!

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Mar 5

Amidst these troubling times, I have some positive personal news to share: I will be joining @imbavienna.bsky.social as a new group leader this fall! 🎉 I am excited for fun projects, surprising discoveries, and great discussions within the fantastic science community @vbcscitraining.bsky.social

Institute of Molecular Biotechnology @imbavienna.bsky.social · Mar 5

Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!

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Jorge Lázaro @jorgelazaro.bsky.social · Jan 24

Very happy to see this out. We observed that different metabolic pathways act as selective modulators of developmental tempo instead of affecting it globally. Congrats to Mitsuhiro for all the hard work!

Miki Ebisuya @ebisuyamiki.bsky.social · Jan 24

Latest from the lab!
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...

Metabolic activities are selective modulators for individual segmentation clock processes - Nature Communications

Metabolism has been considered an attractive candidate as a global modulator of the tempo of multiple developmental processes, including somite segmentation timing. Here they demonstrate that metaboli...

www.nature.com

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Reposted by Jorge Lázaro

Turner Lab @lab-turner.bsky.social · Jan 24

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬

What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬

www.science.org/doi/full/10....

www.science.org

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Denis Duboule @denisduboule.bsky.social · Nov 25

We wrote this for the #SpemannMangold organiser centennial meeting #Freiburg 🙏 It is about whether early embryos should be on top 👆or at the bottom👇of the #hourglass🤔(and other issues)🤓 #InHoxWeTrust 🤟https://pegasus.epfl.ch/?03a82edc91bc5cc1#EKvX77Spd79oMYaisF5hwHBkts6XcGcVnRRDhd5pHNrJ

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Jorge Lázaro @jorgelazaro.bsky.social · Nov 21

The difference in the number of caudal vertebrae (tail length) is most likely controlled by the time it takes until trunk extension stops. This has been nicely addressed here: www.pnas.org/doi/10.1073/...

CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length | PNAS

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Acc...

www.pnas.org

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Jorge Lázaro @jorgelazaro.bsky.social · Nov 21

I like to think that the conserved number of pre-caudal vertebrae in mammals is connected to the scaling between the segmentation clock period and the overall developmental tempo. Allochronic scaling produces similar number of segments.

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Jorge Lázaro @jorgelazaro.bsky.social · Nov 21

Thorough study comparing the vertebral formula of more than 388 tetrapod species. The relationship between Hox expression and vertebral identity is not trivial, specially in birds. www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Jorge Lázaro

Kim Cooper @ucsdcooperlab.bsky.social · Nov 19

Please read and share this ⬇️

journals.biologists.com/dev/article/...

The case against simplistic genetic explanations of evolution

Summary: Extreme traits in animals, from the origin of limbs to the loss of tails, capture public attention. This Review argues that scientists should not seek simple explanations for how they evolved...

journals.biologists.com

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Reposted by Jorge Lázaro

Vikas Trivedi @viktri08.bsky.social · Nov 19

My first post on @bsky.app. So happy to announce that our work has been published in Development by @biologists.bsky.social
doi.org/10.1242/dev....

Also a big thanks for "The people behind the papers" article as well! doi.org/10.1242/dev....

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Reposted by Jorge Lázaro

Teresa Rayon @trayon.bsky.social · Nov 14

2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris.

6-9 May 2025. Save the date!!!

coming-soon.embo.org/w25-105

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