Lightnews — Scholar-powered news

Joe Sabatino @jsabatino37.bsky.social · 10h

That's crazy to me. That model is far more relevant to MOGAD than to MS in my opinion. It's such a crapshoot who you get for reviewers

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Joe Sabatino @jsabatino37.bsky.social · 11h

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

www.science.org/doi/10.1126/...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

www.science.org

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Joe Sabatino @jsabatino37.bsky.social · 15h

Huge congrats to John Pluvinage for joining @arcinstitute.org
as a new Core Investigator! John has already made major contributions to neuroimmunology and I'm sure will continue to do highly innovative, impactful work at Arc.

arcinstitute.org/news/faculty...

Arc Institute Adds Two New Labs; Announces 2025 Cohort of Innovation Investigators and Ignite Awardees | Arc Institute

We are excited to launch three parallel searches for our curiosity-driven Laboratories.

arcinstitute.org

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Joe Sabatino @jsabatino37.bsky.social · 16h

Somehow added some stupid graphic to this post lol. Leaving it here because why not

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Joe Sabatino @jsabatino37.bsky.social · 16h

It was never as good as Twitter in my opinion, but my feeds on both platforms have gradually gone quieter over the last couple of years. I think many people have just lost interest unfortunately. It's a shame because it's by far and away the best way to share new science.

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Reposted by Joe Sabatino

Waggoner Lab @labwaggoner.bsky.social · 1d

Preprint: The Autoantibodyome Neuroimmune Signature of Neurodegeneration
papers.ssrn.com/sol3/papers....

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Reposted by Joe Sabatino

Philip Ahern @philipahern.bsky.social · 1d

I've noted for a long time a desire among many to try & write particular people out of the narrative of the history of Treg research. This review, by the one person everyone agrees is pivotal, provides an accurate assessment for those who don't know the field:

www.annualreviews.org/content/jour...

Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses

▪ Abstract Naturally occurring CD4+ regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic sel...

www.annualreviews.org

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Joe Sabatino @jsabatino37.bsky.social · 2d

A really nice overview of key Treg discoveries relevant for today's exciting Nobel announcement
www.nobelprize.org/uploads/2025...

www.nobelprize.org

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Joe Sabatino @jsabatino37.bsky.social · 5d

Wow, really elegant work! Congrats!

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Reposted by Joe Sabatino

Kilian Schober @kischober.bsky.social · 5d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Reposted by Joe Sabatino

Philip Ahern @philipahern.bsky.social · 6d

Anyone have any expertise/experience with interrogating SNP/InDel in a mouse genome using a reference genome. We have an alignment and are using Integrated Genomics Viewer, but are having trouble figuring some stuff out.

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Joe Sabatino @jsabatino37.bsky.social · 7d

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

www.nature.com/articles/s41...

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis - Nature

An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

www.nature.com

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Joe Sabatino @jsabatino37.bsky.social · 7d

While I don't think sterilizing immunity is likely, I'm hopeful it will protect against at least some EBV-associated diseases.

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Reposted by Joe Sabatino

A/Prof Vilija Jokubaitis @vjokubaitis.bsky.social · 9d

Today, our study looking at the impact of menopause on #MultipleSclerosis disease progression was published in @jamaneurology.com We show that in 987 women with relapsing disease, menopause does not increase the risk of progression. Rather somatic aging is the primary driver of disability in midlife

JAMA Neurology @jamaneurology.com · 9d

In this study, menopause was not the primary driver of multiple sclerosis clinical progression in women at midlife.

ja.ma/4mD3GoK

Figure 2. Predicted Extended Disability Status Scale (EDSS) Inflection Point Analysis. Graph shows EDSS score vs. time since menopause in years, with data points and trend lines indicating a correlation between menopause and disability status.

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Reposted by Joe Sabatino

Waggoner Lab @labwaggoner.bsky.social · 9d

Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis @natcomms.nature.com
www.nature.com/articles/s41...

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Reposted by Joe Sabatino

Edward Nirenberg @enirenberg.bsky.social · 12d

I really appreciate how Dr. Glaucomflecken has become all of medicine and public health's emotional support ophthalmologist.

I sat through 16 hours of ACIP meetings last week. If I do not laugh, I will cry.

The ACIP Panel

YouTube video by Dr. Glaucomflecken

youtu.be

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Reposted by Joe Sabatino

I-75 Scientist @flscitriguy.bsky.social · 12d

Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.

Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...

New Tool to Explore NIH Grant Opportunities | Grants & Funding

grants.nih.gov

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Reposted by Joe Sabatino

Waggoner Lab @labwaggoner.bsky.social · 12d

Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity
www.researchsquare.com/article/rs-7...

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Joe Sabatino @jsabatino37.bsky.social · 12d

Finite-course ocrelizumab in relapsing multiple sclerosis: Results of two prospective open-label trials with matched controls

journals.sagepub.com/doi/10.1177/...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

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Joe Sabatino @jsabatino37.bsky.social · 13d

Epstein-Barr virus reactivation is associated with altered immune cell profiles in peripheral blood and cerebrospinal fluid of treatment-naive multiple sclerosis patients

www.sciencedirect.com/science/arti...

Epstein-Barr virus reactivation is associated with altered immune cell profiles in peripheral blood and cerebrospinal fluid of treatment-naive multiple sclerosis patients

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, with autoimmune and neurodegenerative component…

www.sciencedirect.com

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Reposted by Joe Sabatino

brandon-beaber.bsky.social @brandon-beaber.bsky.social · 16d

"FDA pushes back to December its decision on Sanofi’s tolebrutinib," presumably to wait for the results of the PERSEUS trial-tolebrutinib vs. placebo in primary progressive MS) multiplesclerosisnewstoday.com/news-posts/2...

FDA delays decision until December on Sanofi's tolebrutinib for MS

The U.S. Food and Drug Administration is delaying by three months its decision on whether or not to approve tolebrutinib for treating MS.

multiplesclerosisnewstoday.com

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Reposted by Joe Sabatino

Waggoner Lab @labwaggoner.bsky.social · 18d

An optofluidic workflow for isolating antigen-specific functional CD8+ T cells with or without a prior knowledge of peptide-MHC specificities @cp-iscience.bsky.social
www.cell.com/iscience/ful...

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Reposted by Joe Sabatino

Adrian Liston @labliston.bsky.social · 19d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Reposted by Joe Sabatino

Waggoner Lab @labwaggoner.bsky.social · 20d

A population of anti-CD20–resistant dural B cells that remain in the mouse brain parenchyma at disease remission in progressive multiple sclerosis @jengommerman.bsky.social @jem.org
rupress.org/jem/article-...

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Reposted by Joe Sabatino

Nature Reviews Neurology @natrevneurol.nature.com · 20d

What do the 2024 McDonald criteria mean for the multiple sclerosis prodrome? Helen Tremlett discusses this in our Comment, highlighting the opportunity it presents to better understand the prodromal phase. www.nature.com/articles/s41...

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