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Christophe 🔬 L @christlet.bsky.social · 1d

See you there! Will try to throw a cytoskeleton party for my birthday 🎇

EMBO @embo.org · 1d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Christophe 🔬 L @christlet.bsky.social · 13d

Beautiful live-cell imaging of lysosome tubulation along microtubules in this work just out from @lysoluis.bsky.social et al:
rupress.org/jcb/article/...

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12d

Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules.

🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB

Cryo-ET structure of the microtubule-associated autoinhibited LRRK2^I2020T.

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Christophe 🔬 L @christlet.bsky.social · 21d

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

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King Cada @kingcada.bsky.social · 20d

Woot! Congrats Chen!

Zhicheng Cui | 崔志成 @chen3dem.bsky.social · 21d

Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...

Structural basis for mTORC1 activation on the lysosomal membrane - Nature

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

www.nature.com

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cryoEM papers @cryoempapers.bsky.social · 20d

Structural basis for mTORC1 activation on the lysosomal membrane pubmed.ncbi.nlm.nih.gov/40963021/ #cryoem

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King Cada @kingcada.bsky.social · 21d

Great couple of days working with colleagues at NIEHS and Duke!

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King Cada @kingcada.bsky.social · 21d

Congrats!

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King Cada @kingcada.bsky.social · Sep 5

Congrats James! Well deserved recognition

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The Ragusa Laboratory @ragusalab.bsky.social · Sep 3

I'm very excited to share out latest work now published in Autophagy.

www.tandfonline.com/doi/full/10....

This work was led by Dr. Devika Andhare and demonstrates the membrane binding and clustering capabilities of Atg11 using a new reconstitution system.

Reconstitution of autophagic-like membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimetics

Macroautophagy (hereafter, autophagy) is essential for the degradation of mitochondria from yeast to humans. Mitochondrial autophagy in yeast is initiated when the selective autophagy scaffolding p...

www.tandfonline.com

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 26

Excited to share our new review with @depaceraffa.bsky.social‬, @saikat2025.bsky.social‬, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 21

👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

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Clausen Lab @clausenlab.bsky.social · Aug 21

big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv

Quantitative imaging of lipid transport in mammalian cells

Nature - Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

rdcu.be

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Aug 20

In situ cryo-electron tomography of vaccinia virus exit from infected cells https://www.biorxiv.org/content/10.1101/2025.08.20.671218v1

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Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Lars-Anders Carlson @lacarlson.bsky.social · Aug 13

Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

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King Cada @kingcada.bsky.social · Aug 8

So the cell is just one huge lysosome. Got it.

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James Olzmann @olzmannlab.bsky.social · Aug 6

Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

www.biorxiv.org

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Jim Hurley @jimhurley.bsky.social · Aug 4

Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...

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Jim Hurley @jimhurley.bsky.social · Jul 31

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

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Sam Lewis, Ph.D. @samlewis.bsky.social · Jul 29

Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 26

A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites https://www.biorxiv.org/content/10.1101/2025.07.25.666630v1

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King Cada @kingcada.bsky.social · Jul 25

Wow! Congrats to everyone!

Jim Hurley @jimhurley.bsky.social · Jul 25

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

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Alexey Amunts @amunts.bsky.social · Jul 16

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...

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Alexandre Dumoulin @axonsalex.bsky.social · Jul 16

Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social !
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001

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