Lightnews — Scholar-powered news

Michael Lazarou @lazaroulab.bsky.social · 2d

Check out @antdlewis.bsky.social fun description of organelle contacts here bpod.org.uk/archive/2025...

Great work, really enjoyed it.
I will now always be imagining that organelles are at at a party! 😄

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Reposted by Michael Lazarou

Jim Hurley @jimhurley.bsky.social · 18d

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

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Reposted by Michael Lazarou

Zhicheng Cui | 崔志成 @chen3dem.bsky.social · 21d

Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...

Structural basis for mTORC1 activation on the lysosomal membrane - Nature

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

www.nature.com

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Reposted by Michael Lazarou

Women in Autophagy @womeninautophagy.bsky.social · Sep 3

📅 Less than 2 weeks left to submit your abstract for our 6th Annual Symposium Webinar!

🎉Don’t miss this chance to share your work, hear the latest advances in autophagy research, and connect with a vibrant community! 🎉

The link for abstraction submission is below 👇

forms.office.com/r/wZbTvPePwR

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Reposted by Michael Lazarou

Yasin Dagdas @plantophagy.bsky.social · Sep 1

😺 to see this one out @jcellsci.bsky.social & have a 🌲 planted for it): journals.biologists.com/jcs/article/... am sure more creative people will make better use of this resource 1/2

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Reposted by Michael Lazarou

Takeshi NODA @takeshi-noda.bsky.social · Aug 31

Excited to share our new paper in Nature Communications: Evidence that Mitochondria in macrophages are destroyed by microautophagy 👉 rdcu.be/eDa1S

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Michael Lazarou @lazaroulab.bsky.social · Sep 3

Another important step to understanding why they are so many ATG8 family members and what they are all doing. Great work @plantophagy.bsky.social and team!

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Reposted by Michael Lazarou

Nature Cell Biology @natcellbio.nature.com · Aug 19

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation.
bit.ly/4fLWe99

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux - Nature Cell Biology

Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as ...

bit.ly

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Reposted by Michael Lazarou

Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · Aug 18

Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people:

www.tandfonline.com/doi/full/10.... @sahmri.bsky.social

Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction

Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a ...

www.tandfonline.com

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Reposted by Michael Lazarou

MolinariLab-ER @molinarilab-er.bsky.social · Aug 4

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

rdcu.be

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Reposted by Michael Lazarou

Jim Hurley @jimhurley.bsky.social · Aug 4

Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...

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Reposted by Michael Lazarou

Elias Adriaenssens @elias-adriaenssens.bsky.social · Jul 25

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

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Reposted by Michael Lazarou

Jim Hurley @jimhurley.bsky.social · Jul 25

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

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Reposted by Michael Lazarou

Alex Whitworth lab @labwhitworth.bsky.social · Jul 16

Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.

Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions

Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...

dx.plos.org

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Reposted by Michael Lazarou

Helene Knævelsrud @helene-knavelsrud.bsky.social · Jul 12

In search for some autophagy summer reading?
Check out the full Journal of Molecular Biology special issue «Autophagy accross scales - from molecules to physiology» edited by Sharon Tooze and myself:
www.sciencedirect.com/journal/jour...
@arcticautophagy.bsky.social
@womeninautophagy.bsky.social

Journal of Molecular Biology | Autophagy across scales - from molecules to physiology | ScienceDirect.com by Elsevier

Read the latest articles of Journal of Molecular Biology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

www.sciencedirect.com

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Reposted by Michael Lazarou

MolinariLab-ER @molinarilab-er.bsky.social · Jul 9

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors.
www.biorxiv.org/content/10.1...

The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD

Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles identi...

www.biorxiv.org

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Reposted by Michael Lazarou

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jul 8

Impact of federal funding cuts on science, the progress of knowledge, and our future - an essay by our own Steve Liberles: magazine.hms.harvard.edu/articles/i-t...

“I Think the Entire Future of the United States Is at Stake”

https://magazine.hms.harvard.edu/articles/i-think-entire-future-united-states-stake?utm_source=OCERMarketingCloud&utm_medium=email&utm_campaign=07.08.2025-HMNews&utm_content=‘I+Think+the+Entire+Future+of+the+United+States+Is+at+Risk’

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Reposted by Michael Lazarou

Sierra Palumbos @palumbos.bsky.social · Jul 7

Very excited to share my postdoc work- out now at PNAS!

Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways

Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Michael Lazarou

Terje Johansen - Autophagy Research Group @terjejohansen.bsky.social · Jul 6

WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41...
Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀

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Reposted by Michael Lazarou

Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) @ncmbm.bsky.social · Jun 30

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups!

🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

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Michael Lazarou @lazaroulab.bsky.social · Jul 2

ABSTRACTS CLOSE 18 July!

The 11th International Symposium on Autophagy 2025
📅 16–20 November 2025 | Lorne, Victoria, Australia

Registration: isa11.org

We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.

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Reposted by Michael Lazarou

Helena Cocheme @cochemelab.bsky.social · Jun 27

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

doi.org

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Reposted by Michael Lazarou

Jim Hurley @jimhurley.bsky.social · Jun 25

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The expanding repertoire of ESCRT functions in cell biology and disease - Nature

This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

tinyurl.com

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Reposted by Michael Lazarou

Kohler Proteostasis Lab @vkohler-lab.bsky.social · Jun 23

#Postdoc – #ExcellenceByChoice programme!

Our lab & the Kohler Mito lab are seeking researchers to study specialized mitoribosomes under stress & ageing.

Apply by Aug 17
👉https://www.vkohler-lab.com/join-our-team

#ExcellenceByChoice #Mitochondria #Ageing #Proteostasis

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Reposted by Michael Lazarou

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jun 17

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology

Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...

www.nature.com

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