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Reposted by Zhicheng Cui | 崔志成

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Zhicheng Cui | 崔志成 @chen3dem.bsky.social · 21d

Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...

Structural basis for mTORC1 activation on the lysosomal membrane - Nature

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

www.nature.com

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Akanksha Thawani, PhD @akankshathawani.bsky.social · Aug 19

Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!

We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky

thawanilab.org

The Thawani Lab at Columbia University

The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering

thawanilab.org

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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Apr 18

Krista Freeman et al 𝘊𝘌𝘓𝘓

stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm

can inform precise targeted phage therapies for TB and NTM infections

www.cell.com/cell/fulltex...

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Zhicheng Cui | 崔志成 @chen3dem.bsky.social · Mar 28

Congrats, Aakriti!

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Aakriti Jain @aakritijain.bsky.social · Mar 27

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Anna Clemens, PhD @annaclemens.com · Mar 27

15 bookmark-worthy tools for researchers that cost you nothing and will save you time (& nerves) when researching, writing and publishing.

A thread. 🧵

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Alfredo Sciortino @asciortino.bsky.social · Mar 25

I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...

Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!

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Kelton Minor @keltonminor.bsky.social · Mar 18

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵

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Yilin (she/they) @ check out The Lantern and the Night Moths @yilinwriter.bsky.social · Feb 18

Lol this sign

"Do not bring food into the library

Food residue will attract mice
Mice will acquire knowledge in the library
Get into university
Then replace you"

😂

請不要將食物帶入圖書館

食物殘渣會引來老鼠
老鼠會在圖書館學習知識
考上大學
接著取代你

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Jim Hurley @jimhurley.bsky.social · Feb 6

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

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Thomas Elbenhardt Jensen @elbenhardt.bsky.social · Jan 21

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity

mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....

faseb.onlinelibrary.wiley.com

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Wallace Marshall @wallaceucsf.bsky.social · Dec 23

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

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Joachim Frank @joachim123.bsky.social · Jan 16

You want to build an apparatus for time-resolved cryo-EM?
Easy:
bio-protocol.org/en/bpdetail?...

bio-protocol.org

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Ishier Raote @ishier.bsky.social · Jan 15

Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...

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Jim Hurley @jimhurley.bsky.social · Jan 15

Scientific Director, Cal-Cryo. We are looking for an outstanding microscopist to run our cryo-EM facility (two Krioses and an Arctica), increase training, engagement, and collaboration on campus, expand our user base, and join our community of cutting edge cryo-EM researchers. tinyurl.com/ykasna3p

Scientific Director, Cal-Cryo@QB3, UC Berkeley’s Cryo-EM Facility

University of California, Berkeley is hiring. Apply now!

tinyurl.com

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Joanne Harris @joannechocolat.bsky.social · Jan 16

Unsolicited writing advice, no #7262:
When you're editing a project, try changing the font before you start. It tricks your brain into seeing your words anew, making it easier to spot typos or areas that might need work.

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Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · Jan 15

Wow. This is the first neat paper of 2025! From a baby plate of HEK cells and a uL column

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Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jan 9

🚨 Out now! @marcoyannic.bsky.social and his former colleagues at the Chan Zuckerberg Biohub have unveiled a new study in Cell. The team led by Manuel Leonetti mapped the subcellular distribution of thousands of proteins to create an atlas of the human proteome ➡️ tinyurl.com/ypn65duk

@univie.ac.at

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Eric Topol @erictopol.bsky.social · Jan 9

How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
nature.com/articles/s42...
nature.com/articles/s42...

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Jim Hurley @jimhurley.bsky.social · Jan 9

A unique postdoc position in academic drug discovery is open in the Hurley lab. We have a biochemistry-driven Parkinson’s disease drug discovery project funded and supported by SPARK-NS, which has an innovative model that turbocharges drug discovery in academic labs.
(thread continues)

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Dr. Jean Fan @jef.works · Dec 27

Every year, I give my lab (and myself) a "mini-sabbatical" to pursue creative endeavors outside of regular work/studies.

So I spent some time reflecting on my thoughts on #AI + the role of professors in this AI transformation via a short film 📽️: www.youtube.com/watch?v=6MPs...

#AcademicSky

in the midst of an AI transformation | a short film

YouTube video by Prof. Jean Fan

www.youtube.com

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Rosa Ritunnano @rritunnano.bsky.social · Dec 20

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Dec 19

Check out the latest Discover ASAP episode with @doroteaartscience.bsky.social, a member of CRN Team Hurley, who is making science beautiful and accessible. From mitophagy to #PD research, her work shows how #OpenScience thrives with clear, creative communication.

Learn more 🖼️ 🎥: bit.ly/3VK6Dt4

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Christian Mosimann @chrmosimann.bsky.social · Dec 18

"Till you have sequence confirmation, you are not cloning but clowning." 🧬⭕🤡
- Lab Saying.

#PILife #AlwaysBeCloning

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