Carl (CJ) Litif, Ph.D.
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litif.bsky.social
Carl (CJ) Litif, Ph.D.
@litif.bsky.social
260 followers 320 following 5 posts
Postdoc (Telese Lab - UCSD) 🐭🧠 Investigating the molecular underpinnings of substance use disorder
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Reposted by Carl (CJ) Litif, Ph.D.
cassie-boness.bsky.social
We will still consider applications submitted today and tomorrow!
katiew.bsky.social Katie Witkiewitz @katiew.bsky.social · 26d
Research Assistant Professor position at @unm.edu - join a dynamic team working with @cassie-boness.bsky.social. This position is to work on an NIH grant evaluating personalized medicine approaches for the treatment of alcohol use disorder. Submit via UNMJobs by Nov 26: unm.csod.com/ux/ats/caree...
Research Assistant Professor in Personalized Medicine for the Treatment of Alcohol Use Disorder
Seeking applicants for a Research Assistant Professor faculty position at the University of New Mexico on an NIH funded grant evaluating personalized ...
unm.csod.com
December 2, 2025 at 8:38 PM
Reposted by Carl (CJ) Litif, Ph.D.
ulisespereirao.bsky.social
0/10 Thanks for the interest in our preprint. Some takes say it negates or fully supports the “manifold hypothesis”, neither quite right. Our results show that if you only focus on the manifold capturing most of task-related variance, you could miss important dynamics that actually drive behavior.
dlevenstein.bsky.social Dan Levenstein @dlevenstein.bsky.social · 10d
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
December 2, 2025 at 7:48 AM
Reposted by Carl (CJ) Litif, Ph.D.
dlevenstein.bsky.social
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
November 23, 2025 at 1:38 PM
Reposted by Carl (CJ) Litif, Ph.D.
csybio.bsky.social
I was lucky enough to inherit a bunch of racks where a graduate student had labelled all of them with Rack jokes 😂, perfect. I am dead at Racksputin.
microcentrifuge tube racks with Rack names
November 26, 2025 at 5:37 PM
Reposted by Carl (CJ) Litif, Ph.D.
neurolatine.bsky.social
The Neuro Latine community invites you!

Sunday, November 16
7–9 p.m.
Marriott Marquis San Diego Marina – Grand Blrm 5

#NeuroLatine #SfN2025
November 12, 2025 at 7:51 PM
Reposted by Carl (CJ) Litif, Ph.D.
katiew.bsky.social
We have at least TWO postdoctoral fellowship openings on our @unm.edu @casaa.bsky.social T32 NIAAA Training Grant, best consideration date for applications is Nov 15 2025. Join our phenomenal community and enjoy incredible quality of life in beautiful New Mexico. casaa.unm.edu/training/ins...
Application Process :: Center on Alcohol, Substance use, And Addictions (CASAA) | The University of New Mexico
casaa.unm.edu
November 5, 2025 at 10:30 PM
Reposted by Carl (CJ) Litif, Ph.D.
jessicarbarson.bsky.social
When you happily start the day with not a single meeting scheduled but only manage to write one paragraph of your manuscript because of all the little things that came up during the day
a woman with gray hair is sitting in front of a sign that says por 10 on it
ALT: a woman with gray hair is sitting in front of a sign that says por 10 on it
media.tenor.com
October 23, 2025 at 9:28 PM
Reposted by Carl (CJ) Litif, Ph.D.
bensaunders.bsky.social
Check out our latest, online now at @sfnjournals.bsky.social www.jneurosci.org/content/earl...
Superior colliculus projections drive dopamine neuron activity and movement but not value
To navigate dynamic environments, animals must rapidly integrate sensory information and respond appropriately to gather rewards and avoid threats. It is well established that dopamine (DA) neurons in...
www.jneurosci.org
October 15, 2025 at 8:39 PM
Reposted by Carl (CJ) Litif, Ph.D.
sgrella.bsky.social
First lab paper out today! Student authors: Mikayla Cutler and Abhi Thati 🎉🤩

Hippocampus | Neuroscience Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors
Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction-related ph....
onlinelibrary.wiley.com
October 6, 2025 at 3:38 PM
Reposted by Carl (CJ) Litif, Ph.D.
drcolintmahoney.bsky.social
Long post ahead! I am very excited to be recruiting 1 to 2 #PhD students during this upcoming application cycle for Fall 2026 admission! The Clinical Psychology PhD program at The University of New Mexico (UNM) is absolutely stellar and accredited by both #APA and #PCSAS (Clinical Science model). 1/
September 30, 2025 at 5:14 PM
Reposted by Carl (CJ) Litif, Ph.D.
wiringthebrain.bsky.social
I think about this diagram a lot. This is a *simplified* schematic of *some of* the brain regions and circuits involved in behavioral control. (From: www.sciencedirect.com/science/arti...)
A diagram showing dozens of brain regions densely interconnected by complicated loops
September 15, 2025 at 7:54 AM
Reposted by Carl (CJ) Litif, Ph.D.
sfnjournals.bsky.social
#eNeuro: <a href="https://bsky.app/profile/did:plc:kycdyth6vrvgsxhx7kocf4bd" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@mattjwanat.bsky.social‬ et al. show that the cue-evoked dopamine response in rats signals the duration of the trace period between cue and reward, and relates to the response latency.
https://doi.org/10.1523/ENEURO.0016-25.2025
August 27, 2025 at 11:32 AM
Reposted by Carl (CJ) Litif, Ph.D.
dingdingpeng.the100.ci
Ever stared at a table of regression coefficients & wondered what you're doing with your life?

Very excited to share this gentle introduction to another way of making sense of statistical models (w @vincentab.bsky.social)
Preprint: doi.org/10.31234/osf...
Website: j-rohrer.github.io/marginal-psy...
Models as Prediction Machines: How to Convert Confusing Coefficients into Clear Quantities Abstract Psychological researchers usually make sense of regression models by interpreting coefficient estimates directly. This works well enough for simple linear models, but is more challenging for more complex models with, for example, categorical variables, interactions, non-linearities, and hierarchical structures. Here, we introduce an alternative approach to making sense of statistical models. The central idea is to abstract away from the mechanics of estimation, and to treat models as “counterfactual prediction machines,” which are subsequently queried to estimate quantities and conduct tests that matter substantively. This workflow is model-agnostic; it can be applied in a consistent fashion to draw causal or descriptive inference from a wide range of models. We illustrate how to implement this workflow with the marginaleffects package, which supports over 100 different classes of models in R and Python, and present two worked examples. These examples show how the workflow can be applied across designs (e.g., observational study, randomized experiment) to answer different research questions (e.g., associations, causal effects, effect heterogeneity) while facing various challenges (e.g., controlling for confounders in a flexible manner, modelling ordinal outcomes, and interpreting non-linear models). Figure illustrating model predictions. On the X-axis the predictor, annual gross income in Euro. On the Y-axis the outcome, predicted life satisfaction. A solid line marks the curve of predictions on which individual data points are marked as model-implied outcomes at incomes of interest. Comparing two such predictions gives us a comparison. We can also fit a tangent to the line of predictions, which illustrates the slope at any given point of the curve. A figure illustrating various ways to include age as a predictor in a model. On the x-axis age (predictor), on the y-axis the outcome (model-implied importance of friends, including confidence intervals). Illustrated are 1. age as a categorical predictor, resultings in the predictions bouncing around a lot with wide confidence intervals 2. age as a linear predictor, which forces a straight line through the data points that has a very tight confidence band and 3. age splines, which lies somewhere in between as it smoothly follows the data but has more uncertainty than the straight line.
August 25, 2025 at 11:49 AM
Reposted by Carl (CJ) Litif, Ph.D.
bensaunders.bsky.social
Very excited to share this major update to our paper delineating VTA GABA neuron encoding of valence and decision conflict. Studies led by the amazing @margestelzner.bsky.social. We leaned in here, taking the opportunity to add a lot of cool new data. www.biorxiv.org/content/10.1...
August 21, 2025 at 3:23 PM
Reposted by Carl (CJ) Litif, Ph.D.
jasonsynaptic.bsky.social
Congrats to Sven Bervoets and co-authors for our paper on fly Arc now out in @currentbiology.bsky.social !! This was an awesome collaboration with @thecaronlab.bsky.social’s lab @utah.edu

authors.elsevier.com/c/1lZlk3QW8S...
August 8, 2025 at 11:02 PM
Reposted by Carl (CJ) Litif, Ph.D.
drugmonkey.bsky.social
Why publishing early and often advances science faster than complete story bullshit.

This is related to replication and generalization.

From the Archive: The many benefits of the LPU drugmonkey.wordpress.com/2016/06/29/t...
The many benefits of the LPU
A Daniel Sarewitz wrote an opinion piece in Nature awhile back to argue that the pressure to publish regularly has driven down the quality of science. Moreover, he claims to have identified ……
drugmonkey.wordpress.com
August 8, 2025 at 5:19 PM
Reposted by Carl (CJ) Litif, Ph.D.
natneuro.nature.com
Dopamine dynamics in the nucleus accumbens core reflected decision confidence during evaluation of decisions in an economic foraging task in mice, as well as both past and future value during re-evaluation and change-of-mind

@perothwell.bsky.social

www.nature.com/articles/s41...
Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind - Nature Neuroscience
Differences in neuroeconomic decision-making influence nucleus accumbens dopamine dynamics and reflect choice confidence during evaluation, as well as past and future value during re-evaluation, which...
www.nature.com
August 4, 2025 at 4:29 PM
Reposted by Carl (CJ) Litif, Ph.D.
martinowk.bsky.social
Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠

www.nature.com/articles/s41...
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience
The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...
www.nature.com
July 30, 2025 at 8:51 PM
Reposted by Carl (CJ) Litif, Ph.D.
sebatlab.bsky.social
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
medrxivpreprint.bsky.social medRxivpreprint @medrxivpreprint.bsky.social · Jul 15
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits https://www.medrxiv.org/content/10.1101/2025.07.11.25331310v1
July 16, 2025 at 2:47 PM
Reposted by Carl (CJ) Litif, Ph.D.
statsepi.bsky.social
Good stuff from Alex. I touch on some of these themes here as well, from the perspective of an applied statistician (plus a few more refs on the topic).

statsepi.substack.com/p/statistica... (ICYMI)
July 16, 2025 at 7:18 AM
Reposted by Carl (CJ) Litif, Ph.D.
noahemery.bsky.social
Newest episode of The Addiction Psychologist (@addpsychpodcast.bsky.social) just dropped. In this episode, Dr. Sudie Back discusses Prolonged Exposure for Co-Occurring Substance Use Disorder and PTSD (COPE).

podcasts.apple.com/us/podcast/t...
Dr. Sudie Back - Prolonged Exposure for Substance Use Disorder and PTSD
Podcast Episode · The Addiction Psychologist · 07/14/2025 · 1h 17m
podcasts.apple.com
July 15, 2025 at 1:09 AM
Reposted by Carl (CJ) Litif, Ph.D.
biorxiv-neursci.bsky.social
Long-Term Effects of Adolescent 5F-MDMB-PICA Intravenous self-administration: Neurobehavioral Consequences and medial Prefrontal Cortex Dysfunction in Adult Mice https://www.biorxiv.org/content/10.1101/2025.06.26.661592v1
June 30, 2025 at 1:16 AM
Reposted by Carl (CJ) Litif, Ph.D.
nanopharmnc.bsky.social
Submissions for #WCBR2026 open today! Please go to www.winterbrain.org Big Sky is my absolute favorite venue for this meeting. The science is top notch, the people are great, the meaning is inclusive, and I learned to ski as a 35 year old! Please repost!
Winter Conference on Brain Research January 24th to 29th 2026 Big Sky Montana!
July 1, 2025 at 1:14 PM
Reposted by Carl (CJ) Litif, Ph.D.
morrisonlab.bsky.social
We are delighted to have the cover article in J Neurosci this week! Briefly: inhibition of DA neurons at reward blocks the acquisition of sign tracking; stimulation (or bigger reward) doesn't alter it, but *stopping* stimulation halts acquisition in its tracks. www.jneurosci.org/content/45/2...
Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning
When a cue is located away from its associated reward, some animals will learn to approach the site of reward (goal-tracking behavior) while others will approach the cue (sign-tracking behavior). The ...
www.jneurosci.org
June 30, 2025 at 2:12 PM
Reposted by Carl (CJ) Litif, Ph.D.
drteresa-winst.bsky.social
📣New paper out in Pediatrics about Adolescent & Young Adult OUD Care Access, by part of our UW team💕, & co-first-author, Dr. Alexis Ball!

📝Documenting part of what we already know in practice:

real care options & honest conversations @ drug use matter a lot.

publications.aap.org/pediatrics/a...
Pict of article titled Adolescent and young adult access to opioid use disorder care
June 16, 2025 at 9:34 PM